A5049675599- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- Asthma and respiratory diseases
- Dermatology and Skin Diseases
- Contact Dermatitis and Allergies
- History of Medicine Studies
- Medical History and Research
- Medicine and Dermatology Studies History
- Pediatric health and respiratory diseases
- Transgenic Plants and Applications
- Occupational exposure and asthma
- Adolescent Sexual and Reproductive Health
- Infant Nutrition and Health
- Eosinophilic Esophagitis
- Monoclonal and Polyclonal Antibodies Research
- Media Influence and Health
- Urticaria and Related Conditions
- Clostridium difficile and Clostridium perfringens research
- Toxin Mechanisms and Immunotoxins
- Olfactory and Sensory Function Studies
- Respiratory and Cough-Related Research
- Evolutionary Psychology and Human Behavior
- Drug-Induced Adverse Reactions
Medical University of Vienna
2014-2023
Vienna General Hospital
2010-2018
Christian Doppler Laboratory for Thermoelectricity
2009
Instituto Butantan
2003
Allergens and rhinovirus infections are among the most common elicitors of respiratory diseases. We report construction a recombinant combination vaccine for allergy based on rhinovirus-derived VP1, surface protein which is critically involved in infection cells, nonallergenic peptide major grass pollen allergen Phl p 1. Recombinant hybrid molecules consisting VP1 1-derived 31 aa were expressed Escherichia coli. The did not react with IgE Abs from allergic patients lacked allergenic activity...
The association between cigarette smoke exposure and allergic airway disease is a matter for debate. We sought to investigate in an vitro system whether active smoking reduces the integrity barrier function of respiratory epithelium thus facilitates allergen penetration.We cultured human bronchial epithelial cell line 16HBE14o- transwell culture as surrogate intact epithelium. monolayer was exposed standardized extract (CSE). extent effects trans-epithelial penetration were measured using...
Abstract Background In the house dust mite (HDM) Dermatophagoides pteronyssinus, Der p 1, 2, 5, 7, 21, and 23 have been identified as most important allergens. The aim of this study was to define hypoallergenic peptides derived from sequences six allergens use complete antibody, T cell, cytokine responses in sensitized nonsensitized subjects. Methods IgE reactivity HDM‐allergic non‐HDM‐sensitized individuals 15 HDM established using ImmunoCAP ISAC technology. Thirty‐three covering were...
Abstract Background The nature of epitopes on Bet v 1 recognized by natural IgG antibodies birch pollen allergic patients and pollen‐exposed but non‐sensitized subjects has not been studied in detail. Objective To investigate IgE recognition to study the effects 1‐specific 1‐induced basophil activation. Methods Sera from (BPA, n = 76), without allergy (NBPA, 40) non‐allergic individuals (NA, 48) were tested for IgE, as well 4 reactivity folded recombinant 1, two unfolded fragments comprising...
Late allergic reactions are common in the course of allergen-specific immunotherapy and even occur with allergy vaccines reduced IgE reactivity.We sought to study atopy patch test (APT) T-cell responses recombinant birch pollen allergen Bet v 1 hypoallergenic epitope-containing fragments patients without atopic dermatitis (AD).A clinical was conducted 15 AD (group 1), 5 2), 3), nonallergic subjects 4) by performing skin prick tests APTs rBet fragments. T-cell, cutaneous lymphocyte antigen...
Several hydrolyzed cow's milk (CM) formulas are available for avoidance of allergic reactions in CM-allergic children and prevention allergy development high-risk infants. Our aim was to compare CM regarding the presence immunoreactive components, IgE reactivity, allergenic activity, ability induce T-cell proliferation, cytokine secretion.A blinded analysis eight formulas, one nonhydrolyzed, two partially (PH), four extensively (EH), amino acid formula, using biochemical techniques specific...
The ALEX2-test (MacroArray Diagnostics, Vienna, Austria) is a diagnostic multiplex IgE-test for the simultaneous detection of IgE to 178 allergens and 117 extracts, in addition total IgE. Test results from more than 90 countries are stored on GDPR-compliant cloud server backup, customer support, continuous postmarket surveillance. To improve coverage exposomes global scale further increase sensitivity test, allergen panel was updated ALEX2 ALEX3. By mid-2023, when ALEX3 designed, almost...