Harald F. Krug

ORCID: 0000-0001-9318-095X
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About
Contact & Profiles
Research Areas
  • Nanoparticles: synthesis and applications
  • Air Quality and Health Impacts
  • Graphene and Nanomaterials Applications
  • Nanotechnology research and applications
  • Microplastics and Plastic Pollution
  • Heavy Metal Exposure and Toxicity
  • Chemistry and Chemical Engineering
  • Environmental Toxicology and Ecotoxicology
  • Nanoparticle-Based Drug Delivery
  • Occupational and environmental lung diseases
  • Healthcare and Environmental Waste Management
  • Marine Biology and Environmental Chemistry
  • Recycling and Waste Management Techniques
  • Carbon Nanotubes in Composites
  • Coal and Its By-products
  • RNA Interference and Gene Delivery
  • Toxic Organic Pollutants Impact
  • Pesticide Exposure and Toxicity
  • Pregnancy and preeclampsia studies
  • Advanced biosensing and bioanalysis techniques
  • Lipid Membrane Structure and Behavior
  • Chemical Safety and Risk Management
  • Synthesis and Characterization of Heterocyclic Compounds
  • Cell death mechanisms and regulation
  • Electrochemical Analysis and Applications

Swiss Federal Laboratories for Materials Science and Technology
2012-2022

University of Bern
2022

FZI Research Center for Information Technology
1998-2018

University of St. Gallen
2007-2017

Japan International Cooperation Agency
2017

John Wiley & Sons (Germany)
2017

Society for Chemical Engineering and Biotechnology
2017

Universitat Rovira i Virgili
2017

University of Michigan
2017

Karlsruhe Institute of Technology
2002-2016

GeneCards (www.genecards.org) is a comprehensive, authoritative compendium of annotative information about human genes, widely used for nearly 15 years. Its gene-centric content automatically mined and integrated from over 80 digital sources, resulting in web-based deep-linked card each >73 000 gene entries, encompassing the following categories: protein coding, pseudogene, RNA gene, genetic locus, cluster uncategorized. We now introduce Version 3, featuring speedy sophisticated search...

10.1093/database/baq020 article EN cc-by Database 2010-08-05

New materials of emerging technological importance are single-walled carbon nanotubes (SWCNTs). Because SWCNTs will be used in commercial products huge amounts, their effects on human health and the environment have been addressed several studies. Inhalation studies vivo submerse applications vitro described with diverging results. Why some indicate a strong cytotoxicity do not is what we report here. Data from A549 cells incubated fake cytotoxic effect within MTT assay after 24 h that...

10.1021/nl060177c article EN Nano Letters 2006-04-27

Nanosilver is one nanomaterial that currently under a lot of scrutiny. Much the discussion based on assumption nanosilver something new has not been seen until recently and advances in nanotechnology opened completely application areas for silver. However, we show this analysis form colloidal silver used more than 100 years registered as biocidal material United States since 1954. Fifty-three percent EPA-registered products likely contain nanosilver. Most these applications are...

10.1021/es103316q article EN Environmental Science & Technology 2011-01-10

BackgroundHumans have been exposed to fine and ultrafine particles throughout their history. Since the Industrial Revolution, sources, doses, types of nanoparticles changed dramatically. In last decade, rapidly developing field nanotechnology has led an increase engineered with novel physical chemical properties. Regardless whether this exposure is unintended or not, a careful assessment possible adverse effects needed. A large number projects carried out assess consequences...

10.1289/ehp.0901200 article EN public-domain Environmental Health Perspectives 2009-11-12

Graphing graphene: Because the naming of graphene-based materials (GBMs) has led to confusion and inconsistency, a classification approach is necessary. Three physical-chemical properties GBMs have been defined by GRAPHENE Flagship Project European Union for unequivocal these (see grid).

10.1002/anie.201403335 article EN Angewandte Chemie International Edition 2014-06-10

Nanoparticle exposure in utero might not be a major concern yet, but it could become more important with the increasing application of nanomaterials consumer and medical products. Several epidemiologic vitro studies have shown that nanoparticles can potential toxic effects. However, also offer opportunity to develop new therapeutic strategies treat specifically either pregnant mother or fetus. Previous mainly addressed whether are able cross placental barrier. transport mechanisms underlying...

10.1289/ehp.1409271 article EN public-domain Environmental Health Perspectives 2015-05-08

Tina Buerki-Thurnherr*a, Lisong Xiaob, Liliane Dienera, Osman Arslanb, Cordula Hirscha, Xenia Maeder-Althausa, Kathrin Griederc, Bruno Wampflerc, Sanjay Mathurb, Peter Wicka & Harald F. Krugaa Empa, Swiss Federal Laboratories for Materials Testing and Technology, Laboratory Materials-Biology Interactions, Lerchenfeldstrasse, St. Gallen, Switzerlandb Institute of Inorganic Chemistry, University Cologne, Greinstrasse, Germanyc Biomaterials, Switzerland

10.3109/17435390.2012.666575 article EN Nanotoxicology 2012-03-07

Efficient drug delivery is essential for many therapeutic applications. Some cell-penetrating peptides, peptide mimetics, and peptoids express transport function that, however, lack in most cases specific intracellular destination. In this study, carrier-peptoids with either amino or guanidinium side chains, were investigated regard to their cellular uptake, toxicity, localization. Transport specifically the cytosol nuclei was observed, thus providing a powerful tool targeted delivery.

10.1021/jm070603m article EN Journal of Medicinal Chemistry 2008-01-24

Abstract Background During production and processing of multi-walled carbon nanotubes (MWCNTs), they may be inhaled enter the pulmonary circulation. It is essential that interactions with involved body fluids like surfactant, blood others are investigated, particularly as these could lead to coating tubes affect their chemical physical characteristics. The aim this study was characterize possible coatings different functionalized MWCNTs in a cell free environment. Results To simulate first...

10.1186/1477-3155-8-31 article EN cc-by Journal of Nanobiotechnology 2010-12-01

A comprehensive in vitro assessment of two commercial metal oxide nanoparticles, TiO2 and ZnO, was performed using human monocyte-derived macrophages (HMDM), dendritic cells (MDDC), Jurkat T cell leukemia-derived line. nanoparticles were found to be non-toxic whereas ZnO caused dose-dependent death. Subsequently, global gene expression profiling identify transcriptional response underlying the cytotoxicity by nanoparticles. Analysis done with doses 1 µg/ml 10 after 6 24 h exposure....

10.1371/journal.pone.0068415 article EN cc-by PLoS ONE 2013-07-22
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