A5064310112- Mitochondrial Function and Pathology
- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Cancer, Hypoxia, and Metabolism
- Tryptophan and brain disorders
- Nicotinic Acetylcholine Receptors Study
- Pancreatic function and diabetes
- Endoplasmic Reticulum Stress and Disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroendocrine regulation and behavior
- Genetic Neurodegenerative Diseases
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Muscle Physiology and Disorders
- thermodynamics and calorimetric analyses
- Nanoplatforms for cancer theranostics
- ATP Synthase and ATPases Research
- Analytical Chemistry and Sensors
- Lysosomal Storage Disorders Research
- Viral Infections and Outbreaks Research
- Cardiomyopathy and Myosin Studies
- Spectroscopy Techniques in Biomedical and Chemical Research
- Amino Acid Enzymes and Metabolism
- Sarcoma Diagnosis and Treatment
- Military Defense Systems Analysis
- Axon Guidance and Neuronal Signaling
Sanofi (United States)
2022-2024
John Radcliffe Hospital
2012-2019
University of Oxford
2012-2019
Centre for Women's Development Studies
2018-2019
Science Oxford
2018-2019
Johns Hopkins University
2013-2017
Johns Hopkins Medicine
2014-2017
Curtin University
2017
National Institute on Aging
2010-2013
Institute on Aging
2013
Age-related memory loss is considered to commence at middle-age and coincides with reduced adult hippocampal neurogenesis neurotrophin levels. Consistent physical activity midlife may preserve brain-derived neurotrophic factor (BDNF) levels, new cell genesis, learning. In the present study, 9-month-old female C57Bl/6J mice were housed or without a running wheel injected bromodeoxyuridine (BrdU) label newborn cells. Morris water maze learning, open field rotarod behavior tested 1 6 months...
A neurogenesis defect in a mouse model of Kabuki syndrome can be ameliorated postnatally using histone deacetylase inhibitors.
We tested the hypothesis that fluctuations in levels of kynurenic acid (KYNA), an endogenous antagonist alpha7 nicotinic acetylcholine (ACh) receptor, modulate extracellular ACh medial prefrontal cortex rats. Decreases cortical KYNA were achieved by local perfusion S-ESBA, a selective inhibitor astrocytic enzyme kynurenine aminotransferase II (KAT II), which catalyses formation from its precursor L-kynurenine. At 5 mm, S-ESBA caused 30% reduction levels, was accompanied two-threefold...
Exercise benefits both general health and brain function in rodents humans. However, it is less clear whether physical activity prevents or ameliorates neurodegenerative diseases. The aim of the present study was to determine voluntary wheel running can delay onset reduce severity Huntington's disease (HD) a mouse model. To investigate may HD symptoms lifespan, onset, locomotor activity, glucose levels, weight, striatal volume, inclusions, cognition hippocampal neurogenesis were studied male...
Single-cell Raman microspectroscopy to detect phenylalanine as a potential biomarker for mitochondrial dysfunction and chronic fatigue syndrome.
Pyridoxine is used as a supplement for treating conditions such vitamin deficiency well neurological disorders depression, epilepsy and autism. A significant neurologic complication of pyridoxine therapy peripheral neuropathy thought to be result long-term high dose usage. Although pyridoxine-induced transient can remit after its withdrawal, the process complete recovery slow. Glutamate carboxypeptidase II (GCP II) inhibition has been shown improve symptoms both chemotherapy-...
The mitochondrial energy score (MES) protocol, developed by the Myhill group, is marketed as a diagnostic test for chronic fatigue syndrome/Myalgic Encephalomyelitis (CFS/ME). This study assessed reliability and reproducibility of test, currently provided private clinics, to assess its potential be an NHS accredited laboratory test. We replicated MES protocol using neutrophils peripheral blood mononuclear cells (PBMCs) from CFS/ME patients (10) healthy controls (13). was then repeated in...
Prepulse inhibition (PPI), a measure of sensorimotor gating impaired in patients with schizophrenia, is more sensitive to disruption by apomorphine prepubertal August Copenhagen Irish (ACI) than Sprague-Dawley (SD) rats. In brain regions including the hippocampus, PPI modulated alpha7* nicotinic receptors (nAChRs) and kynurenic acid (KYNA), kynurenine metabolite that blocks alpha7 nAChRs. Here, KYNA levels nAChR activities were measured hippocampi 10- 23-day-old ACI SD rats both sexes....
Background: Mitochondrial diabetes is primarily caused by β-cell failure, but there are gaps in our understanding of pathogenesis. Methods: By reducing glucose, we induced energetic stress two rodent models to assess effects on cellular function. Results: Culturing rat insulin-secreting INS-1 cells low glucose conditions a rapid reduction whole cell respiration, associated with elevated mitochondrial reactive oxygen species production, and an altered glucose-stimulated insulin secretion...
<ns4:p><ns4:italic>Background:</ns4:italic>Mitochondrial diabetes is primarily caused by β-cell failure, but there are gaps in our understanding of pathogenesis.<ns4:italic>Methods:</ns4:italic>By reducing glucose, we induced energetic stress two rodent models to assess effects on cellular function.<ns4:italic>Results:</ns4:italic>Culturing rat insulin-secreting INS-1 cells low glucose conditions a rapid reduction whole cell respiration, associated with elevated mitochondrial reactive oxygen...
Cardiac dysfunction is a common feature of numerous diseases, ranging from metabolic disorders like Mucopolysaccharidosis Type 1 (MPS I), a.k.a. Hurler syndrome to neuromuscular such as Myotonic Dystrophy type (DM1). The ability quantify cardiac abnormalities in animal models these diseases valuable translational tool for preclinical testing novel therapeutic approaches. In contrast methods that measure the left ventricle (LV) phenotype, we employed ultrasound imaging assess ascending aortic...