A5014102060- Systemic Sclerosis and Related Diseases
- Mast cells and histamine
- Dermatologic Treatments and Research
- Inflammatory Myopathies and Dermatomyositis
- Cutaneous lymphoproliferative disorders research
- Systemic Lupus Erythematosus Research
- Autoimmune Bullous Skin Diseases
- Skin Diseases and Diabetes
- Eosinophilic Esophagitis
- Medical Imaging and Pathology Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Northwestern University
2023-2025
Northwestern Memorial Hospital
2023
Massachusetts General Hospital
2022
Harvard University
2022
MedStar Georgetown University Hospital
2019-2020
Georgetown University
2019-2020
African Americans with scleroderma have more severe disease and higher mortality than non-African Americans. Differences in rates of diffuse disease, autoantibody status, or socioeconomic status not completely explained this phenomenon. Our study evaluates these risks at our site.A retrospective comparing American patients seen from 2008 to 2016 was performed. Groups were matched by sex, age first visit, date duration limited versus cutaneous disease. Demographic, serologic, clinical...
Objective To evaluate the psychometric properties of Scleroderma Skin Questionnaire (SSQ), a novel patient-reported outcome (PRO) to assess systemic sclerosis (SSc) related skin symptoms. Methods The SSQ was administered 799 adults (mean age 52.7; 82% female) enrolled in SSc Collaborative National Quality and Efficacy Registry (CONQUER). Internal consistency determined using Cronbach's α McDonald's ω total (ωt). correlation assessed with modified Rodnan Score (mRSS), Physician Global...
Objective Raynaud's phenomenon (RP) is often the initial clinical manifestation of systemic sclerosis (SSc), but some patients develop other manifestations first. To help elucidate diversity SSc presentation in its early stages, we describe and antinuclear antibody (ANA) profiles two cohorts. Methods All patient data GENISOS CONQUER cohorts were reviewed. Both studies enrolled within five years first non‐RP symptom. Results 194/439 (44.2%), 292/938 (31.1%) CONQUER, respectively, had a...
Systemic sclerosis is a highly morbid, complex autoimmune disease that variable both in its phenotype and the attendant mortality driven by such manifestations. This review article synthesizes data from best available meta-analyses, subgroup analyses of single cohorts, subjective comparisons individual cohort studies, which aggregate suggest systemic has been gradually improving over past several decades. also summarizes literature describing various risk factors for sclerosis.
Morphea is an immune-mediated fibrosing skin disorder of the dermis and subcutaneous fat with unclear pathogenesis triggers. Combinations genetic environmental factors leading to immune dysregulation are likely involved. Here, we describe a case generalized morphea profunda occurring after SARS-CoV-2 infection, discuss possible causality pathogenesis.
Abstract Objectives SSc is associated with increased health-care resource utilization and economic burden. The Collaborative National Quality Efficacy Registry (CONQUER) a US-based collaborative that collects longitudinal follow-up data on patients <5 years of disease duration enrolled at scleroderma centres in the USA. objective this study was to investigate relationship between gastrointestinal tract symptoms self-reported CONQUER participants. Methods participants who had completed...
There is limited literature describing the overlap of systemic sclerosis (SSc) and lupus erythematosus (SLE), studies have employed a range case definitions. Our study used new EULAR/American College Rheumatology (ACR) SLE classification criteria to define SSc-SLE cases among our center's SSc cohort.