A5087269472- Emergency and Acute Care Studies
- Cardiac Arrest and Resuscitation
- Trauma and Emergency Care Studies
- Systemic Sclerosis and Related Diseases
- Ethics in Clinical Research
- Ethics in medical practice
- Neonatal Health and Biochemistry
- Neonatal and Maternal Infections
- Injury Epidemiology and Prevention
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Pediatric Urology and Nephrology Studies
- Ethics and Legal Issues in Pediatric Healthcare
- Airway Management and Intubation Techniques
- Sepsis Diagnosis and Treatment
- Neonatal and fetal brain pathology
- Blood transfusion and management
- Clostridium difficile and Clostridium perfringens research
- Viral gastroenteritis research and epidemiology
- Pneumonia and Respiratory Infections
- Heart Failure Treatment and Management
- Palliative Care and End-of-Life Issues
- Dental Health and Care Utilization
- Pharmaceutical studies and practices
- Dermatologic Treatments and Research
- Metabolism and Genetic Disorders
University of Utah
2017-2025
Primary Children's Hospital
2022
University of Utah Health Care
2021
University of Arizona
2021
University of Oklahoma Medical Center
2021
University Medical Center
2021
University Hospital and Clinics
2021
Seattle Children's Hospital
2021
Medical College of Wisconsin
2021
Banner - University Medical Center Tucson
2021
Clinicians often risk stratify young febrile infants for invasive bacterial infections (IBIs), defined as bacteremia and/or meningitis, using complete blood cell count parameters.To estimate the accuracy of individual parameters to identify with IBIs.Planned secondary analysis a prospective observational cohort study comprising 26 emergency departments in Pediatric Emergency Care Applied Research Network from 2008 2013. We included (≥38°C), previously healthy, full-term younger than 60 days...
It is uncertain whether switching to frequent nocturnal hemodialysis improves cognitive function in well-dialyzed patients and how this compares who receive a kidney transplant. We conducted multicenter observational study with longitudinal follow-up of the effect on performance dialysis treatment modality from conventional thrice-weekly hemodialysis, functioning renal transplant or remaining hemodialysis. Neuropsychological tests memory, attention, psychomotor processing speed, executive...
OBJECTIVES: Describe the statistical design of Personalized Immunomodulation in Sepsis-induced Multiple Organ Dysfunction Syndrome (MODS) (PRECISE) study. DESIGN: Children with sepsis-induced MODS undergo real-time immune testing followed by assignment to an immunophenotype-specific study cohort. Interventional cohorts include granulocyte macrophage-colony stimulating factor (GM-CSF) for Reversal Immunoparalysis Pediatric (GRACE)-2 trial, which uses drug GM-CSF (or placebo) reverse...
Multicenter clinical trials play a critical role in the translational processes that enable new treatments to reach all people and improve public health. However, conducting multicenter randomized (mRCT) presents challenges. The Trial Innovation Network (TIN), established 2016 partner with Clinical Translational Science Award (CTSA) Consortium of academic medical institutions implementation mRCTs, consists 3 Centers (TICs) 1 Recruitment Center (RIC). This unique partnership has aimed address...
Objective To evaluate the psychometric properties of Scleroderma Skin Questionnaire (SSQ), a novel patient-reported outcome (PRO) to assess systemic sclerosis (SSc) related skin symptoms. Methods The SSQ was administered 799 adults (mean age 52.7; 82% female) enrolled in SSc Collaborative National Quality and Efficacy Registry (CONQUER). Internal consistency determined using Cronbach's α McDonald's ω total (ωt). correlation assessed with modified Rodnan Score (mRSS), Physician Global...
Large language models (LLMs) can improve text analysis efficiency in healthcare. This study explores the application of LLMs to analyze patient perspectives within exception from informed consent (EFIC) process, which waives emergency research. Our objective is assess whether EFIC interviews with performance comparable human reviewers. We analyzed 102 community 9 sites, each 46 questions, as part Pediatric Dose Optimization for Seizures Emergency Medical Services study. evaluated 5 LLMs,...
Objective Raynaud's phenomenon (RP) is often the initial clinical manifestation of systemic sclerosis (SSc), but some patients develop other manifestations first. To help elucidate diversity SSc presentation in its early stages, we describe and antinuclear antibody (ANA) profiles two cohorts. Methods All patient data GENISOS CONQUER cohorts were reviewed. Both studies enrolled within five years first non‐RP symptom. Results 194/439 (44.2%), 292/938 (31.1%) CONQUER, respectively, had a...
Federal regulations allow exception from informed consent (EFIC) to study emergent conditions when obtaining prospective is not feasible. Little known about public views on including children in EFIC studies. The Pediatric Dose Optimization for Seizures EMS (PediDOSE) trial implements age-based, standardized midazolam dosing pediatric seizures. primary objective of this was determine support and concerns the PediDOSE trial. secondary assess how varied by demographics.
The death rate of brain abscesses in a recently reported series is high, ranging from 36% to 50% all cases. This paper reports experiences with ten cases intracranial secondary ear and sinus infections. Six these are otitic infections three them located the cerebellum. Two cerebellar surgically drained through temporal bone by otologic surgeon, close neurosurgical cooperation. Computerized axial tomography has revolutionized treatment optimizing timing for medical surgical management.
The present study evaluated the daily risk of healthcare-associated infections and sepsis (HAIS) events in pediatric intensive care unit patients with invasive devices. This was a retrospective cohort study. Invasive devices were associated significant HAIS ( p < 0.05). Endotracheal tubes posed greatest (hazard ratio [HR]: 4.39, confidence interval [CI]: 2.59-7.46). Children both central venous catheter (CVC) urinary (UC) had over 2.5-fold increased (HR: 2.59, CI: 1.18-5.68), addition to CVC...
It is unknown if probiotics exert pathogen-specific effects in children with diarrhea secondary to acute gastroenteritis.
Dosimetry for 10-MV x rays has been extended to radiation fields smaller than 4 X cm which may be suitable therapy of small lesions, e.g., intracranial tumors, benign or malignant. Special consideration in this study was given (i) the variation dose with field size (collimator and phantom scatter), (ii) central axis percentage depth doses, (iii) moving-beam distribution. We conclude that simple dosimetric techniques can provide adequate physics background stereotaxic radiosurgery high-energy rays.
Short- and long-term functional impairment after pediatric injury may be more sensitive for measuring quality of care compared with mortality alone. The characteristics injured children adolescents who are at the highest risk unknown.To evaluate categories injuries associated higher prevalence impaired status hospital discharge among to estimate number those in these received treatment trauma centers.This prospective cohort study (Assessment Functional Outcomes Health-Related Quality Life...
Following a child playground equipment injury prevention project conducted in New York State 1977, there was 42 per cent reduction hazards, and 22.4 related injuries treated the two largest hospitals of one program sites. Knowledge about unsafe practices hazards improved after workshops for personnel. This approach to deserves further study.
Trauma is the leading cause of morbidity and mortality in children United States. The antifibrinolytic drug tranexamic acid (TXA) improves survival adults with traumatic hemorrhage, however, has not been evaluated a clinical trial severely injured children. We designed Traumatic Injury Clinical Trial Evaluating Tranexamic Acid Children (TIC-TOC) to evaluate feasibility conducting confirmatory that evaluates effects TXA severe trauma hemorrhagic injuries. evidence torso or brain injuries will...
Objective The study aimed to determine if a program of mid-trimester serum proteomics screening women at low risk for spontaneous preterm birth (sPTB) and the use PTB risk-reduction protocol in those whose results indicated an increased sPTB would reduce likelihood its sequelae. Study Design Prospective comparison outcomes singleton pregnancies with cervical length ≥2.5 cm otherwise randomized undergo or not (NCT 03530332). Screen-positive were offered group interventions reducing PTB....