A5037688701- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Radiomics and Machine Learning in Medical Imaging
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Medical Imaging Techniques and Applications
- Lung Cancer Research Studies
- Advanced X-ray and CT Imaging
- Inflammatory Biomarkers in Disease Prognosis
- Salivary Gland Tumors Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Brain Tumor Detection and Classification
- Cancer-related molecular mechanisms research
- Advanced Radiotherapy Techniques
- Peptidase Inhibition and Analysis
- Brain Metastases and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Ear and Head Tumors
- Cancer Immunotherapy and Biomarkers
- Viral-associated cancers and disorders
- Autophagy in Disease and Therapy
- Management of metastatic bone disease
- Photodynamic Therapy Research Studies
- Ubiquitin and proteasome pathways
Guangxi Medical University
2016-2025
Tumor Hospital of Guangxi Medical University
2014-2022
National Cancer Centre Singapore
2018-2020
Cancer Institute (WIA)
2013
The prognosis of inflammation-related indicators like lactate dehydrogenase/albumin ratio (LAR) and the platelet/lymphocyte (PLR) in nasopharyngeal carcinoma (NPC) is not yet clear. Our objective to establish verify nomogram using LAR PLR for first time explore prognostic value NPC.This was a retrospective collection 1661 patients with non-metastatic NPC admitted our hospital from 2010 2017. final variables overall survival (OS) progression-free (PFS) were selected by Cox regression analysis...
Objective: Radiomics pipelines have been developed to extract novel information from radiological images, which may help in phenotypic profiling of tumours that would correlate prognosis. Here, we compared two publicly available for radiomics analyses on head and neck CT MRI nasopharynx cancer (NPC). Methods materials: 100 biopsy-proven NPC cases stratified by T- N-categories were enrolled this study. Two pipeline, Moddicom (v. 0.51) Pyradiomics 2.1.2) used features MRI. Segmentation primary...
Bevacizumab is considered a promising therapy for brain necrosis after radiotherapy, while some patients fail to derive benefit or even worsen. Hence, we developed and validated radiomics model predicting the response bevacizumab in with radiotherapy.A total of 149 (with 194 lesions; 101, 51, 42 training, internal, external validation sets, respectively) receiving were enrolled. In total, 1,301 radiomic features extracted from pretreatment MRI images each lesion. training set, signature was...
It was previously reported that poly‑(adenosine diphosphate‑ribose) polymerase‑1 (PARP‑1) regulated ionizing radiation (IR)‑induced autophagy in CNE‑2 human nasopharyngeal carcinoma cells. The present study aimed to investigate whether PARP‑1‑mediated IR‑induced occurred via activation of the liver kinase B1 (LKB1)/adenosine monophosphate‑activated protein (AMPK)/mammalian target rapamycin (mTOR) signaling pathway In addition, effect PARP‑1 and AMPK inhibition on sensitization cells...
To establish and validate a nomogram to predict overall survival in locoregionally advanced nasopharyngeal carcinoma (LA-NPC) based on inflammatory biomarkers nutritional indicators.A total of 1304 patients who underwent concurrent chemoradiotherapy (CCRT) with or without induction chemotherapy (IC) adjuvant (AC) were included the study. The prognosis factors (OS) selected by Cox regression analysis nomogram. Concordance index (C-index), calibration curves, decision curve (DCA) Kaplan-Meier...
Background: Previously, we found that c-jun was highly expressed in radiation-resistant human nasopharyngeal carcinoma cells (CNE-2R) compared with (CNE-2). Materials and methods: In this study, first used the scratch assays transwell to detect migration invasion of CNE-2R CNE-2 tested epithelial mesenchymal transformation (EMT)-related proteins E-cadherin N-cadherin by Western blot analysis. Subsequently, knocked down establish effect on EMT, migration, both vitro vivo. Results: A high EMT...
To meet the demand for personalized treatment, effective stratification of patients with metastatic nasopharyngeal carcinoma (mNPC) is essential. Hence, our study aimed to establish an M1 subdivision prognostic prediction and treatment planning in mNPC. This included 1239 mNPC from three medical centers divided into synchronous cohort (smNPC, n = 556) stage metachronous (mmNPC, 683) validate this subdivision. The primary endpoint was overall survival. Univariate multivariate Cox analyses...
Purpose: There is still uncertainty regarding the prognosis of nasopharyngeal carcinoma (NPC) based on hemoglobin, albumin, lymphocytes, and platelets (HALP) score. The aim this study was to build verify a nomogram using HALP score investigate prognostic value NPC identify low-risk patients in T3-4N0-1 guide treatment options. Patients methods: A total 568 with stage T3-4N0-1M0 were recruited study, who given either concurrent chemoradiotherapy (CCRT) or induction chemotherapy (IC) plus...
To explore the influence of circulating lymphocyte subsets, serum markers, clinical factors, and their impact on overall survival (OS) in locally advanced nasopharyngeal carcinoma (LA-NPC). Additionally, to construct a nomogram predicting OS for LA-NPC patients using independent prognostic factors. A total 530 with were included this study. In training cohort, Cox regression analysis was utilized identify which then integrated into nomogram. The concordance index (C-index) calculated both...
Patients with synchronous metastatic nasopharyngeal carcinoma (smNPC) exhibit significant heterogeneity, and clinical prognostic models suitable for this cohort remain limited. We aimed to develop a prediction tool facilitate personalised assessments inform treatment decisions these patients. This retrospective multicentre study enrolled 556 patients smNPC. The training comprised 386 from Guangxi Medical University Cancer Hospital, while the external validation 170 Wuzhou Red Cross Hospital...
// Kai-Hua Chen 1 , Xiao-Dong Zhu 1,2,3 Ling Li Song Qu Zhen-Qiang Liang Xia Xin-Bin Pan Zhong-Guo and Yan-Ming Jiang Department of Radiation Oncology, Affiliated Tumor Hospital Guangxi Medical University, Cancer Institute Zhuang Autonomous Region, Nanning, Guangxi, China 2 Key Laboratory Early Prevention Treatment for Regional High Frequency (Guangxi University), Ministry Education, 3 Correspondence to: Zhu, email: Keywords : nasopharyngeal neoplasm, stage II, concurrent chemoradiotherapy,...
This study aimed to evaluate the safety and efficacy of three-dimensional conformal radiotherapy (3D-CRT) hepatic resection for patients with hepatocellular carcinoma (HCC) involving portal vein tumor thrombus (PVTT).We retrospectively analyzed 323 HCC PVTT. Among them, 134 underwent 3D-CRT, while 189 controls treated (HR). Survival rate prognostic analysis were performed using Kaplan-Meier method Cox regression analyses.The 1-, 2-, 3-year overall survival (OS) RT group HR was 54% vs 62%,...
The present study aimed to the role of autophagy in radiosensitivity radioresistant human nasopharyngeal carcinoma cell line CNE-2R.Before being irradiated, CNE-2R cells were treated with inhibitor chloroquine diphosphate (CDP) or inducer rapamycin (RAPA). Microtubule-associated protein light chain 3 (LC3-II) and p62 assessed using Western blotting analysis 48 hours after irradiated. percentage apoptotic was via flow cytometry. viability evaluated Cell Counting Kit-8 (CCK8). clone formation...
Abstract Serum microRNAs (miRNAs) have been reported as novel biomarkers for various diseases. But circulating predicting the radiosensitivity of nasopharyngeal carcinoma (NPC) not used in clinical practice. To screen out differently expressed serum miRNAs from NPC patients with different may be helpful its individual therapy. were enrolled according to inclusion and exclusion criteria. RNA was isolated these before treatment. We investigated differential miRNA expression profiles using...
To establish and validate an effective nomogram to predict clinical outcomes for patients with locoregionally advanced nasopharyngeal carcinoma (LA-NPC).The clinicopathological parameters follow-up information of 402 NPC (training cohort, n = 302; validation 100) were retrospectively enrolled. The was built the important prognostic variables identified by Cox regression analysis. Overall survival (OS) progression-free (PFS) primary secondary endpoints, respectively. predictive power utility...
We evaluated the survival benefit of providing concurrent chemoradiotherapy (ccrt) plus adjuvant chemotherapy compared with ccrt alone to patients locally advanced nasopharyngeal carcinoma.This retrospective study included 130 carcinoma treated from June 2005 December 2010. Another during same period were matched on age, sex, World Health Organization histology, T stage, N and technology used for radiotherapy. The endpoints overall survival, locoregional failure-free distant metastasis...