A5026560192- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Hematological disorders and diagnostics
- Trace Elements in Health
- Hematopoietic Stem Cell Transplantation
- Tissue Engineering and Regenerative Medicine
- Cytokine Signaling Pathways and Interactions
- Blood disorders and treatments
- Heavy Metal Exposure and Toxicity
- Advanced Proteomics Techniques and Applications
- 3D Printing in Biomedical Research
- Pluripotent Stem Cells Research
- Computational Drug Discovery Methods
- Lymphoma Diagnosis and Treatment
- Cell death mechanisms and regulation
- Chronic Lymphocytic Leukemia Research
- Plant Molecular Biology Research
- Drug Transport and Resistance Mechanisms
- Air Quality and Health Impacts
- Neonatal Respiratory Health Research
- Microtubule and mitosis dynamics
- Microfluidic and Bio-sensing Technologies
- Cell Adhesion Molecules Research
- Electrospun Nanofibers in Biomedical Applications
- Congenital heart defects research
Masaryk University
2008-2025
University Hospital Brno
2021-2025
St. Anne's University Hospital Brno
2021
Charles University
2008-2016
University Hospital in Motol
2014
GATA-2 deficiency was recently described as common cause of overlapping syndromes immunodeficiency, lymphedema, familiar myelodysplastic syndrome or acute myeloid leukemia. The aim our study to analyze bone marrow and peripheral blood samples children with aplastic anemia define prevalence the GATA2 mutation assess whether mutations in transcription factor exhibit specific immunophenotypic features. a consecutively diagnosed cohort 14% advanced forms (refractory excess blasts, refractory...
Abstract Background Lipopolysaccharide (LPS)-induced inflammation of lung tissues triggers irreversible alterations in the parenchyma, leading to fibrosis and pulmonary dysfunction. While molecular cellular responses immune connective tissue cells lungs are well characterized, specific epithelial response remains unclear due lack representative cell models. Recently, we introduced human embryonic stem cell-derived expandable (ELEP) as a novel model for studying injury regeneration. Methods...
Lead oxide nanoparticles (PbONPs), upon their entry into the lungs via inhalation, induce structural changes in primary and secondary target organs. The fate ultrastructural localization of PbONPs organs is known to be dependent on specific organ. Here, we focused differences ability clear inhaled from molecular cellular mechanisms contributing nanoparticle removal. Mice were exposed whole-body inhalation chambers. Clearance ionic lead (Pb/PbONPs) liver was very effective, with being almost...
Abstract TACSTD2 encodes a transmembrane glycoprotein Trop2 commonly overexpressed in carcinomas. While the protein was discovered already 1981 and first antibody–drug conjugate targeting were recently approved for cancer therapy, physiological role of is still not fully understood. In this article, we show that /Trop2 expression evolutionarily conserved lungs various vertebrates. By analysis publicly available transcriptomic data demonstrate level consistently increases infected with...
Abstract Background Inhalation of lead oxide nanoparticles (PbO NPs), which are emitted to the environment by high-temperature technological processes, heavily impairs target organs. These pass through lung barrier and distributed via blood into secondary organs, where they cause numerous pathological alterations. Here, we studied in detail, macrophages as specialized cells involved innate adaptive immune response selected organs unravel their potential involvement reaction subchronic PbO NP...
Acute lymphoblastic leukemia (ALL) cells depend on the microenvironment of host in vivo and do not survive vitro culture. Conversely, suppression non-malignant tissues is one leading characteristics course ALL. Both malignant cell survival may be partly affected by soluble factors within bone marrow (BM) environment. Here, we aimed to identify proteins BM plasma children with ALL that contribute aggressiveness and/or microenvironment-mediated cells. LBMp (leukemic plasma) at time diagnosis...
Abstract The Bcl-2 protein is one of the key components biochemical pathways controlling programmed cell death. function this can be regulated by posttranslational modifications. Phosphorylation has been considered to significantly associated with cycle arrest in G2/M phase cycle, and death caused defects microtubule dynamics. This study shows that phosphorylation induced heavy metals due activation Jun N-terminal kinase pathway not linked arrest. Furthermore, we demonstrate...
Chromosomal instability evoked by abnormalities in centrosome numbers has been traditionally considered as a hallmark of aberrant, typically cancerous or senescent cells. We have reported previously that pristine human embryonic stem cells (hESC) suffer from high frequency supernumerary centrosomes and hence may be prone to undergo abnormal mitotic divisions. also unraveled this phenomenon multicentrosomal mitoses vanishes with prolonged time culture initiation differentiation, it is...
Abstract TACSTD2 encodes a transmembrane glycoprotein Trop2 commonly overexpressed in carcinomas. While the protein was discovered already 1981 and first antibody-drug conjugate targeting were recently approved cancer therapy, physiological role of is still not fully understood. In this article, we show that TACSTD2/Trop2 expression evolutionarily conserved lungs various vertebrates. By analysis publicly available transcriptomic data demonstrate level consistently increases infected with...
Abstract 1448 Poster Board I-471 In acute leukemia (AL), some clinical symptoms may be caused by soluble factors secreted AL cells into the bone marrow (BM) microenvironment. On other hand, are often dependent on microenviroment of host, with most dying during first days after transferred to in vitro. It is not known whether responsible for host-AL interactions since attention paid biology leukemic themselves rather than portion BM microenvironment. We aimed at identifying proteins...