A5007369881- Glioma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Bladder and Urothelial Cancer Treatments
- Neuroblastoma Research and Treatments
- Urinary and Genital Oncology Studies
- Cancer Genomics and Diagnostics
- Ocular Oncology and Treatments
- Genomics and Rare Diseases
- Hedgehog Signaling Pathway Studies
- Chromatin Remodeling and Cancer
- Radiation Therapy and Dosimetry
- Cancer, Hypoxia, and Metabolism
- Head and Neck Surgical Oncology
- Moyamoya disease diagnosis and treatment
- Brain Metastases and Treatment
- Cancer Research and Treatments
- Blood disorders and treatments
- Neurofibromatosis and Schwannoma Cases
- Sarcoma Diagnosis and Treatment
- Neonatal Health and Biochemistry
- Neutropenia and Cancer Infections
- interferon and immune responses
- Esophageal Cancer Research and Treatment
- Genetic factors in colorectal cancer
- Multiple Myeloma Research and Treatments
Merck & Co., Inc., Rahway, NJ, USA (United States)
2023-2025
Dell Children's Medical Center of Central Texas
2020-2021
University of Oklahoma Health Sciences Center
2018-2020
University of Oklahoma
2020
Children's Hospital of Oklahoma
2018
Center for Cancer and Blood Disorders
2018
Children's Cancer Center
2015-2017
Baylor College of Medicine
2015-2017
Texas Children's Hospital
2015-2017
University of Louisville
2014
Whole-exome sequencing (WES) has the potential to reveal tumor and germline mutations of clinical relevance, but diagnostic yield for pediatric patients with solid tumors is unknown.To characterize combined WES children tumors.Unselected newly diagnosed previously untreated central nervous system (CNS) non-CNS were prospectively enrolled in BASIC3 study at a large academic children's hospital during 23-month period from August 2012 through June 2014. Blood samples underwent certified...
Abstract The X-linked BCL-6 co-repressor ( BCOR ) gene encodes a key constituent of variant polycomb repressive complex (PRC) that is mutated or translocated in human cancers. Here we report on the identification somatic internal tandem duplications (ITDs) clustering C terminus 23 27 (85%) pediatric clear cell sarcomas kidney (CCSK) from two independent cohorts. We profile CCSK tumours using combination whole-exome, transcriptome and targeted sequencing. Identical ITD mutations are found...
PURPOSE Children with pediatric gliomas harboring a BRAF V600E mutation have poor outcomes current chemoradiotherapy strategies. Our aim was to study the role of targeted inhibition in these tumors. PATIENTS AND METHODS We collected clinical, imaging, molecular, and outcome information from patients V600E–mutated glioma treated across 29 centers multiple countries. RESULTS Sixty-seven were (pediatric low-grade [PLGGs], n = 56; high-grade [PHGGs], 11) for up 5.6 years. Objective responses...
Abstract Circulating tumor DNA (ctDNA) is emerging as a potential biomarker in early-stage urothelial cancer, but its utility metastatic disease remains unknown. In the phase 3 KEYNOTE-361 study, pembrolizumab with and without chemotherapy was compared alone patients cancer. The study did not meet prespecified efficacy thresholds for statistical significance. To identify biomarkers of response, we retrospectively evaluated association pre- posttreatment ctDNA clinical outcomes subset who...
TPS893 Background: It is hypothesized that V940 (mRNA-4157), an individualized neoantigen therapy consisting of mRNA encoding up to 34 tumor neoantigens, will work in synergy with immune checkpoint inhibitors by generating de novo tumor-specific T-cell activity. In a phase 2 trial patients high-risk melanoma, adjuvant + pembrolizumab had manageable safety profile and improved recurrence-free distant metastasis–free survival versus monotherapy. The 1/2 INTerpath-005 study (NCT06305767) has...
Background Esthesioneuroblastoma (ENB) is a rare cancer of the nasal cavity in children. Radical surgery followed by postoperative radiation considered standard care adults. A similar approach children can lead to significant long-term morbidity. Procedure retrospective multi-institutional review patients less than 21 years age diagnosed with ENB between 1990 and 2014 was performed. Clinical features, treatment, outcome were obtained from medical records. Results Twenty-four identified...
The integration of genome-scale studies such as whole-exome sequencing (WES) into the clinical care children with cancer has potential to provide insight genetic basis an individual's implications for management. This report describes results tumor and germline WES a patient rare diagnosis, rosette-forming glioneuronal fourth ventricle (RGNT). Three pathogenic gene alterations were identified: somatic activating hotspot mutations in FGFR1 (p.N546K) PIK3CA (p.H1047R) variant PTPN11 (p.N308S)...
While clinical and radiographic responses to agents targeting the mitogen-activated protein kinases (MAPK) pathway have been repor-ted in pediatric low-grade gliomas (LGG), early phase trials indicate refractoriness these medications some of patients. We report a patient with disseminated LGG BRAFV600E mutation, which was refractory selumetinib, MEK inhibitor, but subsequently showed immediate response dabrafenib, BRAF sustained effect for 9 months prior progression. In LGGs, treatment...
4563 Background: EV-302/KEYNOTE-A39 (NCT04223856) is a phase 3, randomized, open-label, global study comparing EV+P with platinum-based chemo (PBC) for first-line (1L) treatment (tx) of patients (pts) la/mUC regardless cis eligibility. In EV-302, demonstrated statistically significant and clinically meaningful benefit compared PBC the dual primary endpoints PFS (hazard ratio [HR]: 0.45; P<0.00001) OS (HR: 0.47; in overall pt population (Powles ESMO 2023), reducing risk progression and/or...
A 5-year-old boy presented with worsening headaches for 3 months. On examination, he was found to have a hairless fatty tissue nevus of the scalp (nevus psiloliparus), subcutaneous soft masses on right side his face, neck, mandible and buttock epibulbar dermoid eye (choristoma) (). Magnetic resonance imaging revealed large suprasellar mass, which debulked be pilocytic astrocytoma. Testing not performed BRAF/KIAA1549 fusion or BRAFV600E mutation. Seven years later, started adjuvant...
Background Children with sickle cell disease (SCD) lag in weight and height have a delayed growth spurt compared to normal children. We studied the effect of long‐term erythrocytapheresis (LTE) on children SCD age at which they attained peak velocity. Procedure A retrospective chart review was performed recording weight, height, body mass index (BMI) measurements 36 patients who received LTE every 3–5 weeks for an average duration 5 years. The z ‐scores BMI these were that from Cooperative...
4518 Background: ctDNA is emerging as a potential biomarker of disease in early-stage bladder cancer but less understood advanced UC. We present retrospective analysis pre-treatment and on-treatment data by clinical outcomes with pembro monotherapy versus chemo pts UC from the phase 3 KEYNOTE-361 trial (NCT02853305). Methods: Pts previously untreated were randomly assigned 1:1:1 to + chemo, alone, or alone. Tumor tissue mutations evaluated whole exome sequencing tumor matched normal DNA....
On the basis of significant evidence for safety, international pediatric fever and neutropenia committee recommends identification management patients with "low-risk neutropenia" (LRFN), outpatient oral antibiotics, instead traditional inpatient management. The aim our study was to compare cost-per-patient these 2 strategies, evaluate parent provider satisfaction LRFN. Between March 2016 February 2017, 17 LRFN (median absolute neutrophil count, 90/μL) were managed at a single institution,...
The goal of this study was to evaluate extent surgical resection, and timing volume re-irradiation, on survival for children with locally recurrent ependymoma.Children ependymoma treated a second course fractionated radiotherapy (RT2) from 6 North American cancer centers were reviewed. index time the start RT2 unless otherwise stated.Thirty-five patients included in study. median doses first radiation (RT1) 55.8 54 Gy, respectively. Median follow-up 5.6 years. overall (OS) all 65 months....
Atypical teratoid/rhabdoid tumor (ATRT) is a high-grade central nervous system tumor, with poor prognosis despite intensive multimodal therapy. Loss of nuclear immunostaining for INI1 due to inactivation the hSNF5/INI1 suppressor gene pathognomonic ATRT. We present patient congenital ATRT, who had spontaneous regression without therapy, and disease-free 4 years later. Tumor histopathology showed rhabdoid cells characteristic but immunohistochemistry revealed heterogeneous loss staining. The...
4513 Background: In the randomized, open-label, phase 3 KEYNOTE-361 (NCT02853305) study, superior efficacy was not demonstrated with first-line pembrolizumab ± chemotherapy versus in patients advanced UC. Although formally tested, survival outcomes appeared similar monotherapy (hazard ratio [HR] 0.92; 95% CI, 0.77-1.11). This post hoc exploratory analysis examined complete response (CR) to or KEYNOTE-361. Methods: Patients UC were randomly assigned 1:1:1 receive (200 mg IV every weeks for up...