A5084533427- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Neurofibromatosis and Schwannoma Cases
- Cancer, Hypoxia, and Metabolism
- Epilepsy research and treatment
- Autoimmune Neurological Disorders and Treatments
- Vascular Malformations Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Alcoholism and Thiamine Deficiency
- ATP Synthase and ATPases Research
- Elasticity and Material Modeling
- Intracranial Aneurysms: Treatment and Complications
- Sarcoidosis and Beryllium Toxicity Research
- Brain Metastases and Treatment
- Peripheral Neuropathies and Disorders
- Ubiquitin and proteasome pathways
- Infectious Encephalopathies and Encephalitis
- Soft tissue tumor case studies
- Neurological Complications and Syndromes
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cannabis and Cannabinoid Research
- Ultrasound Imaging and Elastography
- Moyamoya disease diagnosis and treatment
- Advanced X-ray Imaging Techniques
Columbia University Irving Medical Center
2023-2025
Columbia University
2025
Morgan Stanley Children's Hospital
2024
Texas Health Dallas
2023
Nemours Children's Health System
2022
Thomas Jefferson University
2020-2022
Alfred I. duPont Hospital for Children
2019-2021
Dupont Hospital
2019-2021
Neurology, Inc
2021
DuPont (United States)
2020
PURPOSE Children with pediatric gliomas harboring a BRAF V600E mutation have poor outcomes current chemoradiotherapy strategies. Our aim was to study the role of targeted inhibition in these tumors. PATIENTS AND METHODS We collected clinical, imaging, molecular, and outcome information from patients V600E–mutated glioma treated across 29 centers multiple countries. RESULTS Sixty-seven were (pediatric low-grade [PLGGs], n = 56; high-grade [PHGGs], 11) for up 5.6 years. Objective responses...
Pharmacologic therapies for neurofibromatosis type 1-associated plexiform neurofibromas (NF1-PNs) are limited; currently, none US Food and Drug Administration-approved adults.
Chimeric antigen receptor (CAR) T-cell therapy is increasingly used in both oncologic and nononcologic conditions. Although low-grade neurotoxicity may be easily treated, severe remains clinically challenging many times fatal. We present the case of a young adult with relapsed acute lymphoblastic leukemia who developed grade 4 immune effector cell–associated syndrome (ICANS), manifesting as cerebral edema refractory to first-line therapies. share our treatment strategy consisting multiple...
Viral infections can serve as a trigger for variable autoimmune, antibody-mediated demyelinating disorders. There is accumulating evidence that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, causing disease 2019 (COVID-19) infection and responsible current worldwide pandemic, lead to cascade of immune-mediated brain spinal cord injuries. However, such observation in pediatric age group was only reported very few patients. Thus, heterogeneous spectrum this phenomenon...
Introduction: Neurofibromatosis type 1(NF-1) is the commonest neurocutaneous phacomatosis in children. Epilepsy an infrequent comorbidity. Reports of seizure and Electroencephalogram (EEG) characteristics children are sparse. Methods: A retrospective review was performed on patients with NF-1 seen between 2016-2020. Patients co-existing epilepsy were identified. Demographic, clinical, radiological neurophysiological data reviewed analyzed. Results: Out 118 NF1, 16 had epilepsy. 11 focal...
Objective. To describe a unique presentation of neurosarcoidosis. Background. Central nervous system involvement is rare in sarcoidosis. Sarcoidosis can be severe and mistaken for systemic lymphoma. Case Description. A 55-year-old right-handed white male with past medical history obstructive sleep apnea, Raynaud's disease, Hashimoto's thyroiditis was noted to have cognitive decline over duration few weeks 20 lb weight loss. His neurologic exam (including cranial nerves) normal except...
Abstract INTRODUCTION Nivolumab associated neurologic immune-related adverse events (irAEs) have been reported in less than 1% of patients and mainly the adult population. Here we present a pediatric case nivolumab related CNS demyelination. Case description: 15-year-old male with nodular sclerosis stage III classic Hodgkin lymphoma was enrolled to receive chemotherapy following SWOG S1826 protocol. Eight weeks after first dose nivolumab, he had single episode seizure. Prolonged EEG showed...
Pediatric brain tumors have developmental consequences even when prognoses are favorable. Mechanical characterization using magnetic resonance elastography (MRE) has previously revealed adult gliomas softer than tissue. However, pediatric known to differ behaviorally and cytoarchitecturally from tumors. Neurofibromatosis type 1 (NF1) imparts genetic predisposition gliomas, but also results in spongiform regions white matter Here we use MRE for the first time NF1 low-grade find that reference...
To describe presentation of FCCM in an infant. Cerebral cavernous malformations (CCMs) are rare low-flow vascular malformations; hemorrhage can result significant morbidity and mortality. Familial cerebral (FCCM) defined as the occurrence CCMs at least two family members and/or presence multiple a disease causing mutation one three genes which mutations known to cause familial CCM. typically manifests between 20 30 years age, but clinical manifestations occur any age. Our patient is 6 month...
To describe EEG findings in a newborn with congenital Zika Virus (ZIKV) disease.
OBJECTIVE: To describe a unique clinical presentation and rapid recurrence of cervical Schwannoma. BACKGROUND: Schwannomas are known to be benign peripheral nerve tumors, 25% the cases occur in head neck region frequently ( 18%) associated with NF -2 rates (5%) after subtotal resection. CASE DESCRIPTION: 16 year-old right-handed female presented ED for right arm leg weakness, foot drop, patchy paresthesias fall five months prior presentation. Physical exam revealed absence neurocutaneous...
To describe a unique presentation of neurosarcoidosis. Sarcoidosis is multisystem disease which involves formation inflammatory lesions known as granulomas. Central nervous system involvement rare. can be severe and mistaken for systemic lymphoma. 55 year-old right handed white male with OSA, Arthritis, Raynaud’s, Hashimoto’s thyroiditis, was noted to have cognitive decline over few weeks’ duration, well 20lb weight loss. His neurologic exam normal except five-minute recall. He underwent...
Objective: To describe Presentation of FCCM in an infant. Background: Cerebral cavernous malformations (CCMs) are rare low-flow vascular malformations; hemorrhage can result significant morbidity and mortality. Familial cerebral (FCCM) defined as the occurrence CCMs at least two family members and/or presence multiple a disease causing mutation one three genes which mutations known to cause familial CCM. typically manifests between 20 30 years age, but clinical manifestations occur any age....
Objective: To describe laboratory findings in a teenager with progressive ataxia and hypertrophic cardiomyopathy (HCM). Background: There are reported cases of linked to VGKC autoantibodies, however they typically related cerebellar dysfunction. Cases limbic encephalitis, Morvan’s syndrome acquired neuromyotonia have been described the setting autoantibodies. Design/Methods: Here we 19 year old male history scoliosis, concussion, myopic astigmatism, who presented for an evaluation abnormal...
Objective: To evaluate the efficacy of cannabidiol in treatment pediatric seizures based upon published data. Background: Medication-resistant epilepsy poses a challenge field neurology, and is associated with poor clinical outcomes, decreased quality life, high healthcare costs. Patients who continue to have uncontrolled despite multiple antiepileptic drugs (AED’s) other interventions such as ketogenic diet or vagal nerve stimulator are left few options. The changing popular political...
Cerebral cavernomas are encountered in pediatric patients with central nervous system (CNS) tumors and may cause neurological compromise. The incidence of cavernomatous lesions on brain MR treated intraventricular radioimmunotherapy is unknown. 217 were institutional clinical trials 2- 5 serial injections 124I- or 131I- (2- 100 mCi) labeled monoclonal antibodies (cRIT) targeting tumor associated antigens. Pre-treatment at baseline periodically for follow up over several years obtained. Brain...