A5043340540- Vector-borne infectious diseases
- Plant Pathogens and Resistance
- Streptococcal Infections and Treatments
- Plant Pathogens and Fungal Diseases
- Legume Nitrogen Fixing Symbiosis
- Viral Infections and Vectors
- Plant Disease Resistance and Genetics
- Respiratory viral infections research
- Rabies epidemiology and control
- Antifungal resistance and susceptibility
- Bartonella species infections research
- Pneumonia and Respiratory Infections
- Infectious Diseases and Tuberculosis
- Plant nutrient uptake and metabolism
- Plant-Microbe Interactions and Immunity
- Nematode management and characterization studies
- Herpesvirus Infections and Treatments
- Parvovirus B19 Infection Studies
- Bacterial Infections and Vaccines
- Hydrology and Watershed Management Studies
- Soil and Water Nutrient Dynamics
- Orthopedic Infections and Treatments
- Antimicrobial Resistance in Staphylococcus
- Neonatal and Maternal Infections
- Infective Endocarditis Diagnosis and Management
Graduate School Experimental Plant Sciences
2014-2024
Wageningen University & Research
2021-2023
Utrecht University
2015-2022
Deltares
2014-2016
Concordia University
2015
Institute of Vegetables and Flowers
2014
Universidade Federal do Rio Grande do Norte
2014
Alfred I. duPont Hospital for Children
1998-2009
Thomas Jefferson University
1989-2009
Nemours Children’s Clinic
2002-2009
Downy mildews are the most speciose group of oomycetes and affect crops great economic importance. So far, there is only a single deeply-sequenced downy mildew genome available, from Hyaloperonospora arabidopsidis. Further genomic resources for required to study their evolution, including pathogenicity effector proteins, such as RxLR effectors. Plasmopara halstedii devastating pathogen sunflower potential pathosystem model mildews, several Avr-genes R-genes have been predicted unlike...
NIN (NODULE INCEPTION) is a transcription factor that plays key role during root nodule initiation. However, its in later developmental stages unclear. Both mRNA and protein accumulated at the highest level proximal part of infection zone Medicago truncatula nodules. Two nin weak allele mutants, nin-13/16, form rather normal zone, whereas fixation not formed. Instead, with defence responses premature senescence occurred symbiosome development gets arrested. Mutations nin-13/16 resulted...
Objectives. The objectives of this study were to characterize Lyme meningitis (LM) in the pediatric population; compare LM with viral (VM) respect epidemiology, history and physical examination, laboratory data; provide means early distinction neuroborreliosis from other forms aseptic meningitis. Methods. This retrospective analysis involved children admitted Alfred I. duPont Hospital for Children between 1990 1996 whose discharge diagnoses indicated or disease. was defined as presence...
Background. Antimicrobial stewardship programs (ASP) are an effective strategy to ensure that antibiotics used in accordance with scientific evidence improve patient outcome, minimize antimicrobial (AM) resistance, and reduce hospital costs. The article describes the impact of implementation ASP on AM prescription errors. Methods. Prospective, single-center study performed at a tertiary pediatric teaching actively monitored 13 targeted AMs (amikacin, amphotericin B, cefepime, ceftriaxone,...
Abstract. High nitrogen (N) and phosphorus (P) fluxes from upstream agriculture threaten aquatic ecosystems in surface waters estuaries, especially areas characterized by high agricultural N P inputs densely drained catchments like the Netherlands. Controlled drainage has been recognized as an effective option to optimize soil moisture conditions for reduce unnecessary losses of fresh water nutrients. This is achieved introducing control structures with adjustable overflow levels into...
Group A beta-hemolytic streptococcus (GABHS) pharyngitis is a common childhood illness. The clinical diagnosis difficult to determine and laboratory tests have limitations; hence, the condition generally overdiagnosed overtreated. Several pediatric-specific predictive models been published but none prospectively studied.To test performance of previously model for GABHS in children different settings during seasons.Prospective cohort study.Pediatric emergency department 2 pediatric outpatient...
We describe a series of 11 high-risk neonates with infective endocarditis (IE) in this retrospective review. Previously IE has rarely been diagnosed newborns and is usually fatal. The frequency was 4.3 cases per 100 patients. Five patients survived. Microorganisms included gram positives such as S. aureus coagulase-negative Staphylococcus, negatives Klebsiella pneumoniae, Enterobacter cloacae, Enterococcus faecalis, Serratia marcescens, Acinetobacter calcoaceticus. Echocardiographic location...
Pelvic osteomyelitis is unusual in children. We retrospectively reviewed charts of patients with this infection seen at our institution. From 1998 to 2005, 31 pelvic were identified: 19 males and 12 females an age range 1.5 months 17 years 9 months. Duration illness prior admission ranged from 1 day 2.5 Chief complaints included nonspecific pain, fever, limp, decreased weight bearing. Microorganisms isolated Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella, Enterobacter cloacae,...
Peronospora effusa causes downy mildew, the economically most important disease of cultivated spinach worldwide. To date, 19 P. races have been denominated based on their capacity to break resistances, but genetic diversity and evolutionary processes that contribute race emergence are unknown. Here, we performed first systematic analysis showing those emerge by both asexual sexual reproduction. Specifically, studied 26 isolates from 16 mitochondrial nuclear comparative genomics....
A retrospective review of medical records for 32 patients with invasive group C streptococcus (GCS) or G (GGS) infections was performed. MICs and minimum bactericidal concentrations (MBCs) penicillin, erythromycin, vancomycin all isolates were obtained. Tolerance vancomycin, defined as an MBC more times higher than the MIC, exhibited by 18 GGS (54%). The identification tolerance in clinical GCS may have implications treating these seriously ill patients.
Risk factors for Lyme disease and/or infection with Borrelia burgdorferi in children are not defined. A case-control study was performed using patients from our Clinic population. Age- and sex-matched controls the same neighborhood were identified by patients' families. site visit made to each case/control neighborhood. Twenty-four environmental variables, especially ecologic characteristics of home environment examined. Forty-five items surveyed parent questionnaire, including certain...
Objective. To measure possible cognitive sequelae of Lyme disease (LD) within a pediatric population. Design. Prospective, blinded, controlled study skills in children who had been treated for LD. Setting. A children's hospital an area endemic Patients. Forty-one with strictly defined LD were compared 14 control subacute rheumatological diseases, and 23 healthy sibling controls. Outcome measures. Neuropsychologic measures administered to each child assess the following areas: IQ, information...
Peronospora effusa (previously known as P. farinosa f. sp. spinaciae, and here referred to Pfs) is an obligate biotrophic oomycete that causes downy mildew on spinach (Spinacia oleracea). To combat this destructive many disease resistant cultivars have been bred used. However, new Pfs races rapidly break the employed resistance genes. get insight into gene repertoire of identify infection-related genes, genome first reference race, Pfs1, was sequenced, assembled, annotated. Due nature...
A cohort of children with Lyme arthritis was used to evaluate the clinical and serologic profile disease. During a 42-month period (June 1989 December 1991), 44 patients (13 girls 31 boys, ages 4-18 years) were included followed for 6-36 months. Inclusion required presence arthritis, as well positive serology. Thirty-four juvenile rheumatoid or spondyloarthropathy comparison group. Five different patterns found. Preceding erythema migrans seen in seven children. Antinuclear antibodies 30%...
The case of a 4-year-old girl who presented with fever and back pain after being scratched by kitten is presented. diagnosis cat scratch disease osteomyelitis was made the detection Bartonella henselae DNA PCR analysis rib abscess aspirate. Osteomyelitis known complication cat-scratch disease. We present particularly severe that illustrates several important aspects management. Case report. A previously healthy white initially 3-week history unknown origin, up to 40°C. She also complained...
Along with Plasmopara destructor, Peronosopora belbahrii has arguably been the economically most important newly emerging downy mildew pathogen of past two decades. Originating from Africa, it started devastating basil production throughout world, likely due to distribution infested seed material. Here, we present genome this and results comparisons its genomic features other oomycetes. The assembly nuclear was around 35.4 Mbp in length, an N50 scaffold length 248 kbp L50 count 46. circular...