A5012563214- Bioinformatics and Genomic Networks
- Gene expression and cancer classification
- MicroRNA in disease regulation
- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- Genetics and Neurodevelopmental Disorders
- Pancreatic function and diabetes
- RNA modifications and cancer
- Gene Regulatory Network Analysis
- Epigenetics and DNA Methylation
- Inflammatory Bowel Disease
- Genomics and Chromatin Dynamics
- Inflammasome and immune disorders
- Cancer Genomics and Diagnostics
- Immune Response and Inflammation
- Xenotransplantation and immune response
- Extracellular vesicles in disease
- Neurogenesis and neuroplasticity mechanisms
- Congenital heart defects research
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- IL-33, ST2, and ILC Pathways
- Machine Learning in Bioinformatics
- Phagocytosis and Immune Regulation
Samsung Medical Center
2023-2025
University at Buffalo, State University of New York
2020-2025
Sungkyunkwan University
2024
Seoul National University
2017-2020
Inha University
2010
Dongguk University
2010
Mesenchymal stem cell (MSC)-derived small extracellular vesicles (MSC-sEVs) are known to exert immunosuppressive functions. This study showed that MSC-sEVs specifically convert T helper 17 (Th17) cells into IL-17 low-producer (ex-Th17) by degrading RAR-related orphan receptor γt (RORγt) at the protein level. In experimental autoimmune encephalomyelitis (EAE)-induced mice, treatment with was found not only ameliorate clinical symptoms but also reduce number of Th17 in draining lymph nodes and...
The main research topic in this paper is how to compare multiple biological experiments using transcriptome data, where each experiment measured and designed control treated samples. Comparison of usually performed terms the number DEGs an arbitrary combination experiments. This process facilitated with Venn diagram but there are several issues when used analyze DEGs. First, current tools do not provide systematic analysis prioritize genes. Because that generally fully focus genes, genes...
Abstract Background In cancer, mutations of DNA methylation modification genes have crucial roles for epigenetic modifications genome-wide, which lead to the activation or suppression important including tumor suppressor genes. Mutations on modifiers could affect enzyme activity, would result in difference genome-wide profiles and, downstream Therefore, we investigated effect such as DNMT1, DNMT3A, MBD1, MBD4, TET1, TET2 and TET3 through a pan-cancer analysis. Methods First, profiles. We...
PRC2 creates the repressive mark histone H3 Lys27 trimethylation. Although is involved in various biological processes, its role glial development remains ambiguous. Here, we show that required for oligodendrocyte (OL) differentiation and myelination, but not OL precursor formation. PRC2-deficient lineage cells differentiate into precursors, they fail to trigger molecular program highlighting essential directing timing of precursors. null aberrantly induce Notch pathway genes acquire...
Abstract Background Studies on the interaction between tumour‐infiltrating immune cells (TIICs) and tumour in melanoma arising from congenital melanocytic nevus (CMN) are lacking. Objective The aim of this study was to determine intratumoral landscape TIICs during invasion metastasis. Methods Tissue specimens were obtained patients with originating CMN. Differential gene expression metastasis determined using spatial transcriptomics. Results As depth increased, LGALS3 , known induce...
Heterozygous mutations in the FOXG1 gene manifest as syndrome, a severe neurodevelopmental disorder characterized by structural brain anomalies, including agenesis of corpus callosum, hippocampal reduction, and myelination delays. Despite well-defined genetic basis therapeutic interventions targeting underlying cause are nonexistent. In this study, we explore potential adeno-associated virus 9 (AAV9)-mediated delivery gene. Remarkably, intracerebroventricular injection AAV9-FOXG1 to Foxg1...
Single allelic mutations in the forebrain-specific transcription factor gene FOXG1 lead to syndrome (FS). To decipher disease mechanisms of FS, which vary depending on mutation types, patient-specific animal models are critical. Here, we report first FS mouse model, Q84Pfs heterozygous (Q84Pfs-Het) mice, emulates one most predominant variants. Remarkably, Q84Pfs-Het mice recapitulate various human phenotypes across cellular, brain structural, and behavioral levels, such as microcephaly,...
Abstract Crohn’s disease (CD) is a chronic inflammatory bowel (IBD) and considered Th1-mediated disease, supported by the over-expression of interferon-gamma (IFN-γ) in intestinal lamina propria. To evaluate response epithelial cells (IECs) to IFN-γ, we established small organoids (enteroids) derived from non-IBD controls CD patients. IFN-γ stimulated programmed cell death (PCD) IECs both control enteroids dose-dependent manner. Pyroptosis, apoptosis necroptosis were activated enteroids,...
Background Biomarkers associated with the occurrence of sudden cardiac arrest (SCA) are not currently utilized in clinical practice. We aimed to identify novel protein biomarkers using proteomic profiling and evaluate their predictive power alongside traditional cardiovascular risk factors. Methods A total 42 SCA patients medical causes, aged ≤ 65 years whose initial rhythm was shockable, age- sex-matched controls were analyzed. The serum samples obtained after emergency department visits...
Crohn's disease (CD) is a chronic inflammatory bowel (IBD) and considered Th1-mediated disease, supported by the over-expression of interferon-gamma (IFN-γ) in intestinal lamina propria. IFN-γ has pleiotropic effect on epithelial cells (IECs), suggesting that IFN-γ-induced responses may differ between cell types. We established human small organoids (enteroids) derived from non-IBD controls CD patients. Using enteroids, major response IECs induced was evaluated, focusing programmed death...
<title>Abstract</title> To investigate transcriptomic signatures of Parkinson's disease (PD) and the Parkinsonian subtype Multiple System Atrophy (MSA-P) in substantia nigra pars compacta (SNpc), we conducted transcriptome analysis using in-situ hybridization on paraffin-embedded SNpc tissues from postmortem brains. The study included 2 MSA-P patients, PD healthy controls (HC), with 12 regions interest (ROIs) selected dorsal to ventral medial lateral aspects SNpc. A total 72 ROIs 6...
Abstract Background: Childhood cancer survivors with cancer-predisposing variants are at increased risk of developing subsequent malignant neoplasms (SMNs). Although panel sequencing is commonly used for diagnostics, its overall yield has been lower than expected. Methods: From 1, 435 pediatric solid tumor patients diagnosed or treated between 1994 and 2014, we previously identified 72 individuals who developed SMNs; germline DNA samples were available 40 them. Whole genome (WGS) was...
Single allelic mutations in the FOXG1 gene lead to syndrome (FS). To understand pathophysiology of FS, which vary depending on mutation types, patient-specific animal models are critical. Here, we report a Q84Pfs heterozygous (Q84Pfs-Het) mouse model, recapitulates various FS phenotypes across cellular, brain structural, and behavioral levels. Q84Pfs-Het cortex shows dysregulations genes controlling cell proliferation, neuronal projection migration, synaptic assembly, vesicle transport. The...
miRNAs are small non-coding RNAs that regulate gene expression by binding to the 3'-UTR of genes. Many recent studies have reported play important biological roles regulating specific mRNAs or sequence-based target prediction algorithms been developed predict miRNA targets. However, these methods not designed for condition-specific predictions and produce many false positives; thus, expression-based predictions. A typical strategy utilize data is leverage negative control on To positives, a...
Identifying perturbed pathways in a given condition is crucial understanding biological phenomena. In addition to identifying individually, pathway analysis should consider interactions among pathways. Currently available interaction prediction methods are based on the existence of overlapping genes between pathways, protein-protein (PPI) or functional similarities. However, these approaches just as set genes, thus they do not take account topological features. addition, most existing handle...
To understand the dynamic nature of biological process, it is crucial to identify perturbed pathways in an altered environment and also infer regulators that trigger response. Current time-series analysis methods, however, are not powerful enough simultaneously. Widely used methods include determine gene sets such as differentially expressed genes or clusters these need be further interpreted terms using other tools. Most pathway designed for time series data they do consider gene-gene...
Online signature verification is used widely for user authentication in many applications. In existing systems, one confidential level usually as the threshold verifications. This causes high false rejection ratio (FRR) to systems which less important, and on other hand, acceptance (FAR) more critical. Thus, applying multi-confidential levels crucial solve this problem. Also, data mining techniques can be appropriately define levels. paper proposes a hybrid online system supporting defined...
Hyeran Shim, Kiwon Jang, Yeong Hak Bang, Hoang Bao Khanh Chu, Jisun Kang, Jin-Young Lee, Sheehyun Cho, Hong Seok Jongbum Jeon, Taeyeon Hwang, Soobok Joe, Jinyeong Lim, Ji-Hye Choi, Eun Hye Joo, Kyunghee Park, Ji Hwan Moon, Kyung Yeon Han, Yourae Hong, Woo Yong Hee Cheol Kim, Seong Hyeon Yun, Beom Yoon Ah Jung Wook Huh, Kyong Shin, Dae Pyo, Hyekyung Hae-Ock Woong-Yang Jin Ok Yang & Young-Joon Kim. BMB Reports -0001;0:. https://doi.org/10.5483/BMBRep.2023-0093
Clinical islet transplantation has recently been a promising treatment option for intractable type 1 diabetes patients. Although early graft loss well studied and controlled, the mechanisms of late largely remains obscure. Since long-term survival had not achieved in xenotransplantation, it impossible to explore mechanism loss. Fortunately, recent advances where consistent (≥6 months) adult porcine grafts was five independent, diabetic nonhuman primates (NHPs) enabled us investigate on...
<italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Motivation:</i> Identifying differentially expressed genes (DEGs) in transcriptome data is a very important task. However, performances of existing DEG methods vary significantly for sets measured different conditions and no single statistical or machine learning model detection perform consistently well traits. In addition, setting cutoff value the significance differential expressions one...
Single allelic mutations in the gene encoding forebrain-specific transcription factor FOXG1 lead to syndrome (FS). Patient-specific animal models are needed understand etiology of FS, as FS patients show a wide spectrum symptoms correlated with location and mutation type gene. Here we report first patient-specific mouse model, Q84Pfs heterozygous (Q84Pfs-Het) mice, mimicking one most predominant single nucleotide variants FS. Intriguingly, found that Q84Pfs-Het mice faithfully recapitulate...