A5072592839- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Dementia and Cognitive Impairment Research
- Transcranial Magnetic Stimulation Studies
- Alzheimer's disease research and treatments
- Botulinum Toxin and Related Neurological Disorders
- Genetic Neurodegenerative Diseases
- Acute Ischemic Stroke Management
- Neurological and metabolic disorders
- Neurological Disease Mechanisms and Treatments
- Functional Brain Connectivity Studies
- Restless Legs Syndrome Research
- Advanced MRI Techniques and Applications
- Folate and B Vitamins Research
- Neurological Disorders and Treatments
- Epilepsy research and treatment
- Ginkgo biloba and Cashew Applications
- Atrial Fibrillation Management and Outcomes
- Glycogen Storage Diseases and Myoclonus
- Ultrasound and Hyperthermia Applications
- Vestibular and auditory disorders
- Sleep and Wakefulness Research
- Cardiovascular Syncope and Autonomic Disorders
- Stroke Rehabilitation and Recovery
- Cerebrovascular and Carotid Artery Diseases
Incheon St. Mary's Hospital
2016-2025
Catholic University of Korea
2016-2025
Seoul St. Mary's Hospital
2010-2016
In-Q-Tel
2016
May Institute
2015
Korea Advanced Institute of Science and Technology
2015
Merck Canada Inc. (Canada)
2011
Jewish General Hospital
2011
Federación Española de Enfermedades Raras
2011
Neurology, Inc
2010
Transcranial focused ultrasound (FUS) is making progress as a new non-invasive mode of regional brain stimulation. Current evidence FUS-mediated neurostimulation for humans has been limited to the observation subjective sensory manifestations and electrophysiological responses, thus warranting identification stimulated regions. Here, we report FUS sonication primary visual cortex (V1) in humans, resulting elicited activation not only from sonicated area, but also network regions involved...
Abstract Focused ultrasound (FUS) has recently been investigated as a new mode of non-invasive brain stimulation, which offers exquisite spatial resolution and depth control. We report on the elicitation explicit somatosensory sensations well accompanying evoked electroencephalographic (EEG) potentials induced by FUS stimulation human cortex. As guided individual-specific neuroimage data, was transcranially delivered to hand cortex among healthy volunteers. The sonication elicited transient...
Transcranial focused ultrasound (FUS) is gaining momentum as a novel non-invasive brain stimulation method, with promising potential for superior spatial resolution and depth penetration compared to transcranial magnetic or direct current stimulation. We examined the presence of tactile sensations elicited by FUS two separate regions in humans—the primary (SI) secondary (SII) somatosensory areas hand, guided individual-specific functional resonance imaging data. Under image-guidance,...
Several case studies have reported on restless legs syndrome (RLS) associated with stroke. In this study, we investigated the prevalence and lesion topography of poststroke RLS. There were 137 patients ischemic stroke included in study. The diagnosis RLS was made 1 month after index using criteria established by International Study Group. All enrolled underwent magnetic resonance imaging within 7 days onset stroke-related calculated, lesions analyzed. Among patients, 17 (12.4%) diagnosed a...
Purpose: Increasing attention has been paid to low-intensity transcranial focused ultrasound (tFUS) for its potential therapeutic effects in Alzheimer's disease (AD). While preclinical studies have shown promising of tFUS AD models, efficacy and safety remain unclear humans. In this pilot study, we investigated the on blood-brain barrier opening, regional cerebral metabolic rate glucose (rCMRglu), cognition patients with AD.Methods: After receiving institutional review board approval, four...
Dysphagia occurs in the majority of patients with Parkinson's disease (PD) and is known to correlate abnormalities oropharyngeal function. The aim this study was evaluate pharyngoesophageal activity early-stage PD. Newly diagnosed PD a symptom duration not exceeding 3 years were included. All questioned about symptoms dysphagia underwent combined multichannel intraluminal impedance manometry multiple rapid swallow tests. Fifty-four (22 men 32 women, 67.1 ± 10.3 years) enrolled. Parkinsonian...
White matter hyperintensities (WMH) have been associated with cognitive impairment in elderly persons and patients Alzheimer disease. However, the role of WMH Parkinson disease (PD) dementia remains to be elucidated.The cohort for this study comprised 71 consecutive PD, all whom completed a clinical assessment, neuropsychologic investigation, magnetic resonance imaging brain. were rated using semiquantitative visual rating system proposed by Scheltens et al.The PD group had significantly...
Abstract Background Mild cognitive impairment (MCI) is a syndrome that disrupts an individual’s function but preserves activities of daily living. MCI thought to be prodromal stage dementia, which patients’ lives and causes severe dysfunction. Although extensive clinical trials have attempted slow or stop the dementia conversion, results been largely unsuccessful. The purpose this study was determine whether noninvasive electrical stimulation changes glucose metabolism. Methods Sixteen...
Background and purpose Reduction of metaiodobenzylguanidine ( MIBG ) uptake has been observed in almost all patients with Parkinson's disease PD ), associated hyposmia, orthostatic hypotension rapid eye movement sleep behavioral disorder RBD ). In contrast, a subgroup normal have reported to milder preserved cognition compared those lower . The aim this study was investigate whether non‐motor manifestations differ between abnormal myocardial uptake. Methods Among 160 de‐novo cases , 44 had...
Parkinson’s disease (PD) and Alzheimer’s (AD) can coexist in severely affected; elderly patients. Since they have different pathological causes lesions consequently require treatments; it is critical to distinguish PD-related dementia (PD-D) from AD. Conventional electroencephalograph (EEG) analysis has produced poor results. This study investigated the possibility of using relative wavelet energy (RWE) coherence (WC) between PD-D patients; AD patients healthy subjects. In EEG signals; we...
Preclinical studies have suggested that low-intensity transcranial focused ultrasound (tFUS) may therapeutic potential for Alzheimer's disease (AD) by opening the blood-brain barrier (BBB), reducing amyloid pathology, and improving cognition. This study investigated effects of tFUS on BBB opening, regional cerebral metabolic rate glucose (rCMRglu), cognitive function in AD patients. Eight patients with received image-guided to right hippocampus immediately after intravenous injection...
Microglia are involved in immune surveillance intact brains and become activated response to inflammation neurodegeneration. have different functions, neuroprotective or neurotoxic, according aging patients with PD. The clinical effect of microglia Alzheimer's disease (AD) is poorly defined. This prospective study was conducted investigate the effects process newly diagnosed AD.We examined 532 AD 119 healthy controls, differences hs-CRP between these groups were investigated. classified into...
Autonomic symptoms are commonly observed in patients with Parkinson's disease (PD) and often limit the activities of daily living. The Scale for Outcomes disease-Autonomic (SCOPA-AUT) was developed to evaluate quantify autonomic PD. goal this study translate original SCOPA-AUT, which written English, into Korean its reliability validity PD patients.For translation, following processes were performed: forward backward expert review, pretest pre-final version development final SCOPA-AUT...
Several clinical studies have demonstrated that patients with essential tremor (ET) may cognitive deficits; however, there are no published data regarding detailed neuropsychological assessments of ET without dementia. We therefore conducted a case-control study function in ET.The cohort for this comprised 34 consecutive dementia and 33 age-matched controls, all who completed dementia-screening questionnaire underwent investigation.Severe impairments were observed most domains the group...
High-sensitivity C-reactive protein (hs-CRP) has been shown to be a powerful predictor of coronary ischemic events. However, the prognosis functional disability in patients with cerebrovascular disease not well established. Therefore, we performed this study determine prognostic significance hs-CRP levels after acute stroke.A total 417 Korean stroke were examined within 24 h symptom onset. measurements obtained on admission and seventh hospital day. The correlations between concentration...
Background and purpose: Decreased visual function is one of the non-motor dysfunctions Parkinson's disease (PD). Recent evidences suggest that essential tremor (ET) not 'pure' motor disorder there growing evidence this a multiple-system disorder. In some cases, it difficult to differentiate ET from PD. addition, considerable controversy regarding relationship between PD ET. The objective study was compare color discrimination dysfunction amongst patients with investigate clinical relevance....
<i>Background:</i> High-sensitivity C-reactive protein (hs-CRP) is a sensitive systemic marker of inflammation, and increased levels hs-CRP are associated with inflammatory reactions. Microglia-mediated neuroinflammation has been hypothesized to play an important role in the pathogenesis idiopathic Parkinson’s disease (PD). However, clinical value PD poorly defined. Therefore, we conducted this study investigate patients PD. <i>Methods:</i> We examined 212 de novo PD,...
Haptoglobin (Hpg) is known to have several functional properties, including antioxidant and anti-inflammatory activities. In addition, it has been shown that the pathogenesis of neurodegenerative disorders, such as Alzheimer's disease (AD), involves inflammation well oxidative stress. However, evidence suggesting an association between serum Hpg level AD lacking. Therefore, we conducted this study in order investigate whether associated with AD.We compared levels 121 patients newly diagnosed...
Background Low-intensity focused ultrasound (LIFU), a non-invasive targeted brain stimulation technology, has shown promise for therapeutic applications in Alzheimer's disease (AD) patients. Despite its potential, the implications of repeated LIFU neuromodulation AD patients remain to be investigated. Objective This pilot study evaluated safety and potential improve cognition functional connectivity following treatment Methods Ten early-stage underwent six sessions neuronavigation-guided...