An extremely simple and rapid (seconds) approach is reported to directly synthesize gram quantities of P-doped graphitic porous carbon materials with controlled P bond configuration. For the first time, it demonstrated that can be used as a selective metal free catalyst for aerobic oxidation reactions. The work function materials, its connectivity configuration, correlation catalytic efficiency are studied established. In direct contrast N-doped graphene, higher show high activity in...

Transition-metal-catalyzed alkylation reactions of arenes have become a central transformation in organic synthesis. Herein, we report the first general strategy for with styrenes and alcohols catalyzed by carbon-based materials, exploiting unique property graphenes to produce valuable diarylalkane products high yields excellent regioselectivity. The protocol is characterized wide substrate scope functional group tolerance. Notably, this process constitutes application promote direct C–C...

The unique properties of a holey graphene sheet, referred to as sheet with nanoholes in its basal plane, lead wide range applications that cannot be achieved by nonporous counterpart. However, the large‐scale solution‐based production requires oxide (GO) or reduced GO (rGO) starting materials, which take hours days for fabrication. Here, an unexpected discovery without holes can controllably, directly, and rapidly (tens seconds) fabricated from graphite powder via one‐step‐one‐pot microwave...

Hummers method is commonly used for the fabrication of graphene oxide (GO) from graphite particles. The oxidation process also leads to cutting sheets into small pieces. From a thermodynamic perspective, it seems improbable that aggressive, somewhat random oxidative could directly result in nanosheets without destroying intrinsic π-conjugated structures and associated exotic properties graphene. In method, both KMnO4 NO2+ (nitronium ions) concentrated H2SO4 solutions act as oxidants via...

Phthalocyanine-loaded graphene nanoplatform for imaging-guided combinatorial phototherapy Olena Taratula,1 Mehulkumar Patel,2 Canan Schumann,1 Michael A Naleway,1 Addison J Pang,1 Huixin He,2 Oleh Taratula1 1Department of Pharmaceutical Sciences, College Pharmacy, Oregon State University, Portland, OR, USA; 2Department Chemistry, Rutgers University-Newark, Newark, NJ, USA Abstract: We report a novel cancer-targeted nanomedicine platform for imaging and prospect future treatment...

Inspired by the remarkable electronic and optical properties of single walled carbon nanotubes (SWNTs), various molecular sensing devices with sensitivity down to molecule level have been developed. However, most approaches such as field effect transistors or near infrared (NIR) fluorescence require rigorous debundling separation metallic tubes semiconducting in order reach desired high sensitivity. Interestingly, all nanomaterials including nanotubes, graphite, graphene, even amorphous...

Anti- and pro-oxidant activities of different manganese oxide nanoparticles their implications in cell viability redox balances.

We report on magnetic susceptibility, NMR, and EPR measurements of pristine Fe-doped micro- nanosized graphenes (LGr NGr), prepared by a unique microwave enabled technique from graphite particles. Significant orbital diamagnetism in the studied compounds (∼70% that bulk graphite) is revealed. At T < 30 K, weak paramagnetism due to edge π-electronic spin states observed. Reduction lateral size graphene sheets results suppression strengthening paramagnetic contribution an increased number open...

An ecofriendly approach for graphene fabrication is developed, where no toxic and metal containing compounds were used byproducts generated.

Background: Dengue is a viral disease transmitted by mosquitoes that has rapidly spread across various regions, with its global incidence rising significantly in recent decades. Currently, nearly half of the world’s population at risk. The dengue virus (DENV), mainly Aedes mosquitoes, especially aegypti, can cause symptoms ranging from mild flu-like illness to severe conditions such as hemorrhagic fever (DHF) and shock syndrome (DSS), both which be fatal if not treated appropriately....

Platelets (PLTs) for transfusion can be stored up to 7 days at room temperature (RT). The quality of apheresis PLTs decreases over storage time, which affects PLT hemostatic functions. Here, we characterized the membranous particles produced by lesion (PSLPs), including degranulated PLTs, ghosts, membrane fragments, and extracellular vesicles (PEVs). PSLPs generated in platelet units were analyzed on 1, 3, 5, RT storage. A differential centrifugation a sucrose density gradient used separate...

Direct α-alkylation of carbonyl compounds represents a fundamental bond forming transformation in organic synthesis. We report the first ketone-alkylation using olefins and alcohols as simple alkylating agents catalyzed by graphene oxide. Extensive studies surface suggest pathway involving dual activation both coupling partners. Notably, we show that polar functional groups have stabilizing effect on GO surface, which results net enhancement catalytic activity. The method alkylation...

Different nanomaterials are under development for various biomedical applications in which nanoparticles contact blood and vasculature. Therefore, investigating the interactions between vascular endothelial cells (ECs) is of great importance. Here, we show effects polyamidoamine (PAMAM) dendrimers two different sizes, generation 2 (G2; approximately 3 nm diameter) 7 (G7; 9 nm), with neutral (OH-terminated), anionic (COOH-terminated), cationic (NH2-terminated) surface modifications on...

The physicochemical properties of complex drug formulations, including liposomes, suspensions, and emulsions, are important for understanding release mechanisms, quality control, regulatory assessment. It is ideal to characterize these formulations in their native hydrated state. This article describes the characterization a frozen-hydrated state using cryogenic scanning electron microscopy (cryo-SEM). In comparison other techniques, such as optical or room-temperature microscopy, cryo-SEM...

To determine suitable alternatives to human blood for in vitro dynamic thrombogenicity testing of biomaterials, four different animal sources (ovine, bovine, and porcine from live donors, abattoir blood) were compared fresh blood.To account coagulability differences between individual donors species, each pool was heparinized a donor-specific concentration immediately before flow loop system. The target heparin level established using static thrombosis pre-test. For testing, whole...

ABSTRACT To develop standardized in vitro thrombogenicity test methods for evaluating medical device materials, three platelet activation biomarkers, beta‐thromboglobulin (β‐TG), factor 4 (PF4), soluble p‐selectin (CD62P), and a plasma coagulation marker, thrombin–antithrombin complex (TAT), were investigated. Whole blood, drawn from six healthy human volunteers into Anticoagulant Citrate Dextrose Solution A was recalcified heparinized over concentration range of 0.5–1.5 U/mL. The blood...

To develop and standardize a reliable in vitro dynamic thrombogenicity test protocol, the key parameters that could impact thrombus formation need to be investigated understood. In this study, we evaluated effect of temperature on thrombogenic responses (thrombus surface coverage, weight, platelet count reduction) various materials using an blood flow loop system. Whole from live sheep cow donors was used assess four with varying potentials: negative-control polytetrafluoroethylene (PTFE),...