A5007603152- Pharmaceutical and Antibiotic Environmental Impacts
- Antibiotic Resistance in Bacteria
- Animal Nutrition and Physiology
- Microbial infections and disease research
- Antibiotics Pharmacokinetics and Efficacy
- Pain Management and Opioid Use
- Salmonella and Campylobacter epidemiology
- Anesthesia and Pain Management
- Phytoestrogen effects and research
- Animal Behavior and Welfare Studies
- Listeria monocytogenes in Food Safety
- Bacteriophages and microbial interactions
- Escherichia coli research studies
- Gut microbiota and health
- Natural Products and Biological Research
- Pharmacogenetics and Drug Metabolism
- Evolution and Genetic Dynamics
- Diet and metabolism studies
- Vibrio bacteria research studies
- Birth, Development, and Health
- Aquaculture disease management and microbiota
- Anesthesia and Sedative Agents
- Animal Disease Management and Epidemiology
- Livestock and Poultry Management
- Synthesis and Biological Evaluation
Natural Remedies (India)
2023
Universidad Complutense de Madrid
2015-2021
Wageningen University & Research
2018
Utrecht University
2018
Hospital La Paz Institute for Health Research
2015
Hospital General de Niños Ricardo Gutierrez
1978
Abstract The emergence of antimicrobial resistance (AMR) is one the biggest health threats globally. In addition, use drugs in humans and livestock considered an important driver resistance. commensal microbiota, especially intestinal has been shown to have role AMR. Mobile genetic elements (MGEs) also play a central facilitating acquisition spread AMR genes. We isolated Escherichia coli (n = 627) from fecal samples respectively 25 poultry, 28 swine, 15 veal calf herds 6 European countries...
Previous studies in food-producing animals have shown associations between antimicrobial use (AMU) and resistance (AMR) specifically isolated bacterial species. Multi-country data are scarce only describe between-country differences. Here we investigate the pig faecal mobile resistome characteristics at farm-level across Europe.A cross-sectional study was conducted among 176 conventional farms from nine European countries. Twenty-five samples fattening pigs were pooled per farm acquired...
Farm-level quantification of antimicrobial usage (AMU) in pig farms.In a cross-sectional study, AMU data on group treatments administered to single batch fattening pigs from birth slaughter (group treatment data) and antimicrobials purchased during 1 year (purchase were collected at 180 farms nine European countries. was quantified using incidence (TI) based defined (DDDvet) used (UDDvet) daily doses (DCDvet) (UCDvet) course doses.The majority weaners (69.5% total TIDDDvet) followed by...
To determine associations between farm- and flock-level antimicrobial usage (AMU), farm biosecurity status the abundance of faecal resistance genes (ARGs) on broiler farms.In cross-sectional pan-European EFFORT study, conventional farms were visited faeces, AMU information records collected. The resistomes pooled samples determined by metagenomic analysis for 176 farms. A meta-analysis approach was used to relate total class-specific ARGs (expressed as fragments per kb reference million...
To control the emerging threat of antimicrobial resistance, international policy appeals for appropriate monitoring usage (AMU) at supranational, species and farm level. The aim this study was to quantify AMU in broilers flock level nine European countries.Antimicrobial treatment data one purchased antimicrobials over year were collected 181 broiler farms. Afterwards quantified using incidence (TI) per 100 days based on Defined Daily Dose (DDDvet), Course (DCDvet) or Used (UDDvet) values....
Quantitative data on fecal shedding of antimicrobial-resistant bacteria are crucial to assess the risk transmission from dogs humans. Our first objective was investigate prevalence quinolone/fluoroquinolone-resistant and beta-lactam-resistant Enterobacteriaceae in France Spain. Due particular concern about possible extended-spectrum cephalosporin (ESC)-resistant isolates their owners, we characterized ESBL/pAmpC producers collected dogs. Rectal swabs 188 dogs, without signs diarrhea that had...
ABSTRACT Metagenomic sequencing has proven to be a powerful tool in the monitoring of antimicrobial resistance (AMR). Here, we provide comparative analysis resistome from pigs, poultry, veal calves, turkey, and rainbow trout, for total 538 herds across nine European countries. We calculated effects per-farm management practices usage (AMU) on broilers, calves. also an in-depth study associations between bacterial diversity, AMR abundances as well co-occurrence taxa genes (ARGs) universality...
In this study, we characterized two tigecycline-resistant Klebsiella pneumoniae isolates from dog urine samples. The were genetically unrelated, belonging to sequence type 11 (ST11) and ST147, both classically related human isolates. To the best of our knowledge, is first identification animals. We unveil here worrisome circulation among animals bacterial clones resistant last-resort antibiotic.
Plasmid conjugation is a major route for the spread of antibiotic resistance genes. Inhibiting has been proposed as feasible strategy to stop or delay propagation Several compounds have shown be inhibitors in vitro, specifically targeting plasmid horizontal transfer machinery. However, vivo efficiency and applicability these clinical environmental settings remained untested. Here we show that synthetic fatty acid 2-hexadecynoic (2-HDA), when used fish food supplement, lowers frequency model...
This study was performed to determine how two of the most important isoflavones, genistein and daidzein, affect gonadal axis in male prepuberal rats. One hundred seventy-five Wistar rats were allocated into seven groups: one control group six experimental groups that orally administered a high or low dose genistein, daidzein mixture both. Testosterone determination assayed by EIA. The testes body weights measured, histology epididymis with sperm content epididymal count evaluated. In group,...
Food-producing animals are an important reservoir and potential source of transmission antimicrobial resistance (AMR) to humans. However, research on AMR in turkey farms is limited. This study aimed identify risk factors for three European countries (Germany, France, Spain). Between 2014 2016, faecal samples, usage (AMU), biosecurity information were collected from 60 farms. The level samples was quantified ways: By measuring the abundance genes through (i) shotgun metagenomics sequencing (
Puberty is considered a critical period on development that involved sexual maturation and morphological changes. Isoflavones have been described as endocrine disruptors in male rats. Therefore, the present study attempt to evaluate effect daily intake of low high doses isoflavones exert into hormonal regulation take place during puberty by analyzing levels serum testes steroid pituitary hormones. 108 pre-puberal Wistar rats (30 days old) were randomly divided three groups; control,...
Antimicrobial resistance (AMR) threatens our public health and is mainly driven by antimicrobial usage (AMU). For this reason the World Health Organization calls for detailed monitoring of AMU over all animal sectors involved. Therefore, we aimed to quantify on turkey farms. First, turkey-specific Defined Daily Dose (DDDturkey) was determined. These were compared broiler alternative from European Surveillance Veterinary Consumption (DDDvet), that mention DDDvet as a proxy other poultry...
Animal health and welfare have become topics of increasing public interest. Especially improvements in the food-producing animals are currently being intensively researched. To be able to routinely assess quality individual pig herds for benchmarking purposes a simple robust way, short easy use measuring tool is needed. Since very elaborate assessment tools Welfare Quality (R) (WQ) project (FOOD-CT-2004-506508) too time-consuming an during regular veterinary herd visit, record indicators...
The current study was carried out to evaluate the effect of phytogenic feed additive (PFA) on egg production performance in Hy-Line brown layer birds. A flock size 14190 birds selected commercial poultry farm which maintained with standard management practices at Spain. baseline data (T1) recorded for 20 days, thereafter, were fed PFA (500 g/ton) (T2) supplemented 11 days. parameters viz. number eggs, hen day (HDEP) and recorded. Results revealed that supplementation improved no. eggs/day...