A5033454756- Glycosylation and Glycoproteins Research
- Venous Thromboembolism Diagnosis and Management
- Renal cell carcinoma treatment
- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Cancer Treatment and Pharmacology
- Advanced Breast Cancer Therapies
- COVID-19 and healthcare impacts
- Ferroptosis and cancer prognosis
- Palliative Care and End-of-Life Issues
- Proteoglycans and glycosaminoglycans research
- Neutropenia and Cancer Infections
- Olfactory and Sensory Function Studies
- Glutathione Transferases and Polymorphisms
- Acute Myocardial Infarction Research
- COVID-19 Clinical Research Studies
- Carbohydrate Chemistry and Synthesis
- Immune cells in cancer
- Glioma Diagnosis and Treatment
- Protease and Inhibitor Mechanisms
- Clusterin in disease pathology
- Polydiacetylene-based materials and applications
- Central Venous Catheters and Hemodialysis
- Healthcare cost, quality, practices
- Hepatocellular Carcinoma Treatment and Prognosis
Central University Hospital of Asturias
2014-2024
Instituto de Investigación Sanitaria del Principado de Asturias
2022
Our objective was to develop a prognostic stratification tool that enables patients with cancer and pulmonary embolism (PE), whether incidental or symptomatic, be classified according the risk of serious complications within 15 days.The sample comprised cases from national registry thromboembolism in (1075 14 Spanish centres). Diagnosis 53.5% events this registry. The Exhaustive CHAID analysis applied 10-fold cross-validation predict development following PE diagnosis.About 208 (19.3%, 95%...
Cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitors demonstrated activity in terms of progression-free survival (PFS) advanced dedifferentiated liposarcoma (DD-LPS), a sarcoma with CDK4 amplification. overexpression is by far more common than amplification sarcomas it might be rational target for CDK inhibitors. Preclinical investigators this study found that overexpression, while not CDKN2A, was the most consistent predictive factor palbociclib efficacy sarcomas. Advanced adult-type...
The purpose of our study was to analyse the usefulness Choi criteria versus RECIST in patients with pancreatic neuroendocrine tumours (PanNETs) treated sunitinib.A multicentre, prospective conducted 10 Spanish centres. Computed tomographies, at least every 6 months, were centrally evaluated until tumour progression.One hundred and seven included. Median progression-free survival (PFS) by 11.42 (95% confidence interval [CI], 9.7-15.9) 15.8 months CI, 13.9-25.7). PFS (Kendall's τ = 0.72)...
Heparan sulfate proteoglycans (HSPGs) are complex molecules which play a role in the invasion and growth metastatic properties of cancerous cells. In this work we analyze changes patterns expression HSPGs left sided colorectal cancer (LSCRC), both non-metastatic, results also compared with those previously obtained for right tumors (RSCRCs).Eighteen LSCRCs were studied using qPCR to proteoglycan core proteins enzymes involved heparan chain biosynthesis. Certain carry chondroitin chains so...
A proportion of patients with metastatic colorectal cancer (mCRC) are still able to continue active therapy after their progression fluoropyrimidines, oxaliplatin, and irinotecan regimens. Studies suggest that gemcitabine fluoropyrimidines synergic antimetabolites. The purpose was evaluate gemcitabine-capecitabine (Gem-Cape) in heavily pretreated mCRC thus assess possible predictive factors for progression-free survival (PFS) overall (OS).This analysis performed on 119 evaluable irinotecan,...
The saccharide chains of heparan sulfate appear to be involved in several aspects Alzheimer disease (AD) pathogenesis. Their structural complexity is due the expression different isoenzymes. We studied differential transcription chain biosynthesis AD brains, analyzing brain regions patients with extents pathology. transcriptomic study was performed by RT-PCR using samples amygdala, anterior hippocampus, posterior claustrum, calcarine fissure, globus pallidus and cerebellum from mild,...
Abstract Sarcomas are mesenchymal cancers which often show an aggressive behavior and patient survival largely depends on early detection. In last years, much attention has been given to the fact that cancer patients release specific odorous volatile organic compounds (VOCs) can be efficiently detected by properly trained sniffer dogs. Here, we have evaluated for first time ability of dogs (n = 2) detect osteosarcoma cell cultures samples. One two was successfully discriminate...
Glioblastoma stands as the most frequent primary brain tumor. Despite multimodal therapy for glioblastoma patients, survival rate is very low, highlighting need novel therapies that improve patient outcomes. Immune checkpoint blockade strategies are achieving promising results in a myriad of tumors and several studies have reported its efficacy at preclinical level. ILT2 immune exerts an inhibitory effect via interaction with classical non-classical HLA class-I molecules. Herein, we report...
11511 Background: CDK4/6 inhibitors showed a favorable progression-free survival (PFS) in DD LPS, sarcoma bearing 12q 13-15 amplicon that implies CDK4 amplification. The median PFS was 4 and 7 months (m) for palbociclib abemaciclib, respectively. Preclinical experiments 10 cell lines 6 PDX models, including only one higher efficacy of anti-CDK4 cases with high expression low p16. This rationale supported the design phase II trial exploring wide range sarcomas, excluding LPS. Methods:...
Small leucine-rich proteoglycans (SLRPs) regulate different processes and undergo significant alterations in various diseases. Colon carcinomas (CCs) are heterogeneous pathologies with important clinical molecular differences depending on their location, which makes it interesting to analyze the SLRPs right- left-sided tumors (RS- LSCCs). SLRP transcription levels were studied 32 CCs using qPCR compared healthy colon mucosae samples from same patients, 20 of them LSCCs remaining 12 RSCCs....
665 Background: It is widely known the causal relationship establised between tobacco use and development of renal cancer known. Nevertheless, impact smoking on efficacy safety anti-angiogenic drugs unclear. Sunitinib a tyrosine kinase inhibitor with proven metastatic cell carcinoma (mRCC). Methods: A retrospective analysis was carried out including 194 mRCC patients (pts) who received in single Institution (Hospital Universitario Central de Asturias) high incidence this disease. The aim...
603 Background: the prognosis and treatment of advanced RCC has improved over last decade due to a number effective anti-angiogenic immune checkpoint inhibitors (ICPI) therapies. Certain clinical factors, such as low Karnofsky status (≤ 70%); less than one year period from diagnosis administration; serum hemoglobin; high corrected calcium; lactate dehydrogenase; elevated neutrophil count or platelet exceeding upper limit normal range, have been able stratify patients into three distinct...
e14034 Background: Cancer patients under cytotoxic treatment with fever used to have an average time of antibiotics administration 11h (median 3h43min) when admitted and identified at the Emergency Room Service in third level Central University Hospital Asturias. International guidelines recommend antibiotic first hour: so called “Golden Hour”. This delay implies increase patient morbidity as well cost managing this complication. Methods: Data was collected from our electronic registry after...
e24098 Background: Patient reported outcomes measures (PROMs) represent a tool to objectively assess the health of cancer patients. PROMs may complement oncological evaluations by adding patients’ perspectives on their care priorities. Aim: address more accurately management tumor related symptoms or drug toxicities bring he therapies patients best quality life possible. Methods: Data was collected from our electronic registry after proper authorization and corresponding anonymization....