A5019775934- Bioactive Natural Diterpenoids Research
- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Plant-based Medicinal Research
- Plant biochemistry and biosynthesis
- Phytochemicals and Antioxidant Activities
- Biological Activity of Diterpenoids and Biflavonoids
- Natural Antidiabetic Agents Studies
- Traditional and Medicinal Uses of Annonaceae
- Microbial Natural Products and Biosynthesis
- Plant-derived Lignans Synthesis and Bioactivity
- Marine Sponges and Natural Products
- Traditional Chinese Medicine Analysis
- Phytochemistry and Bioactive Compounds
- Hepatitis B Virus Studies
- Essential Oils and Antimicrobial Activity
- Enzyme Catalysis and Immobilization
- Biochemical Analysis and Sensing Techniques
- Plasma Applications and Diagnostics
- Bioactive Compounds and Antitumor Agents
- Natural Compounds in Disease Treatment
- Bioactive natural compounds
- Medicinal Plant Extracts Effects
- Drug-Induced Hepatotoxicity and Protection
- Radical Photochemical Reactions
University of Copenhagen
2016-2025
Yunnan Normal University
2014-2024
Chengdu Medical College
2008-2023
Novogene Bioinformatics Institute
2022-2023
Dalian University of Foreign Languages
2021-2022
Shanghai Ocean University
2021
Shanghai Harbour Engineering Design & Research Institute
2021
Chinese Academy of Sciences
2008-2019
Institute of Electrical Engineering
2018-2019
Fujian Agriculture and Forestry University
2019
Abstract Eukaryotic cells use G-protein coupled receptors to sense diverse signals, ranging from chemical compounds light. Here, we exploit the remarkable sensing capacity of construct yeast-based biosensors for real-life applications. To establish proof-of-concept, focus on cannabinoids because their neuromodulatory and immunomodulatory activities. We a CB 2 receptor-based biosensor, optimize it achieve high sensitivity dynamic range, prove its effectiveness in three applications increasing...
The presence of anticancer clerodane diterpenoids is a chemotaxonomic marker for the traditional Chinese medicinal plant Scutellaria barbata, although molecular mechanisms behind biosynthesis are unknown. Here, we report high-quality assembly 414.98 Mb genome S. barbata into 13 pseudochromosomes. Using phylogenomic and biochemical data, mapped plastidial metabolism kaurene (gibberellins), abietane, diterpenes in three species family Lamiaceae (Scutellaria baicalensis, Salvia splendens),...
Taxol is a potent drug used in various cancer treatments. Its complex structure has prompted extensive research into its biosynthesis. However, certain critical steps, such as the formation of oxetane ring, which essential for activity, have remained unclear. Previous proposals suggested that follows acetylation taxadien-5α-ol. Here, we proposed ring formed by cytochrome P450-mediated oxidation events occur prior to C5 acetylation. To test this hypothesis, analyzed genomic and transcriptomic...
Abstract Humankind relies on specialized metabolites for medicines, flavors, fragrances, and numerous other valuable biomaterials. However, the chemical space occupied by metabolites, and, thus, their application potential, is limited because biosynthesis based only a handful of building blocks. Engineering organisms to synthesize alternative blocks will bypass this limitation enable sustainable production molecules with non-canonical structures, expanding possible applications. Herein, we...
The worldwide increasing incidence of type 2 diabetes has fueled an intensified search for food and herbal remedies with preventive and/or therapeutic properties. Polygonum cuspidatum Siebold & Zucc. (Polygonaceae) is used as a functional in Japan South Korea, it also well-known traditional antidiabetic herb China. In this study, dual high-resolution α-glucosidase protein-tyrosine phosphatase 1B (PTP1B) inhibition profiling was the identification individual constituents directly from crude...
A double layer DBD plasma jet driven by a pulsed generator is used for SiO x thin film deposition. The effects of dielectric and conductive targets on discharge behavior properties are analyzed. Different fraction N2 added to the working gas (argon) modulate growth rate. electrical property optical emission at different positions characterized. Film surface morphology, composition thickness measured targets. excitation temperature (T exc ), vibrational vib ) rotational rot calculated....
Abstract Background Celastrol is a promising anti-obesity agent that acts as sensitizer of the protein hormone leptin. Despite its potent activity, sustainable source celastrol and derivatives for further pharmacological studies lacking. Results To elucidate biosynthetic pathway reconstruct it in Saccharomyces cerevisiae , we mined root-transcriptome Tripterygium wilfordii identified four oxidosqualene cyclases 49 cytochrome P450s candidates to be involved early steps biosynthesis. Using...
Natural products are widely used as pharmaceuticals, flavors, fragrances, and cosmetic ingredients. Synthesizing evaluating analogs of natural can considerably expand their applications. However, the chemical synthesis is severely hampered by highly complex structures. This particularly evident in isoprenoids, largest class products. Here, we develop a yeast cell-based biocatalytic method that enables systematic biotechnological production different classes isoprenoids (including...
Two new tetrahydrofuran lignans, kadlongirins A and B (1, 2), a cadinane-type sesquiterpenoid, 2,7-dihydroxy-11,12-dehydrocalamenene (3), together with seven known grandisin, fragransin B1, vladirol F, kadsuralignan C, otobaphenol, isoanwulignan, 4-[4-(3,4-dimethoxyphenyl)-2,3-dimethylbutyl]-2-methoxy-phenol, were isolated from the leaves stems of Kadsura longipedunculata. The structures these compounds elucidated by spectroscopic methods. Compound 2 exhibited weak anti-human...
In this study, we report the functional characterization of a new ent-kaurene diterpenoid termed pharicin A, which was originally isolated from Isodon xerophilus, perennial shrub frequently used in Chinese folk medicine for tumor treatment. Pharicin A induces mitotic arrest leukemia and solid tumor-derived cells identified by their morphology, DNA content, marker analyses. A-induced is associated with unaligned chromosomes, aberrant BubR1 localization, deregulated spindle checkpoint...