A5055534689- Marine Sponges and Natural Products
- Traditional and Medicinal Uses of Annonaceae
- Aquaculture disease management and microbiota
- Parasite Biology and Host Interactions
- Microbial Natural Products and Biosynthesis
- Phytochemical Studies and Bioactivities
- Phytochemistry and Bioactive Compounds
- Coccidia and coccidiosis research
- Bioactive Natural Diterpenoids Research
- Echinoderm biology and ecology
- Coral and Marine Ecosystems Studies
- Biochemical Analysis and Sensing Techniques
- Myxozoan Parasites in Aquatic Species
- Zebrafish Biomedical Research Applications
- Seed and Plant Biochemistry
- Helminth infection and control
- Synthesis and Biological Activity
- Food Science and Nutritional Studies
- Cancer, Lipids, and Metabolism
- Consumer Attitudes and Food Labeling
- Chemistry and Chemical Engineering
Al-Azhar University
2021-2025
Cairo University
2024
ABSTRACT Background Fascioliasis represents one of the most significant parasitic and foodborne zoonotic diseases in world. Resistance to currently deployed human veterinary flukicides is a growing health problem. Zinc oxide nanoparticles (ZnO‐NPs) have developed enormous importance nanomedicine. The current study aims evaluate flukicide activity ZnO‐NPs on adult stages Fasciola hepatica , vitro assay. Methods Mature flukes F. were collected from biliary tracts cattle liver main...
One of the most common tumors to cause death worldwide is colon cancer. This study aims investigate antitumor potency Litophyton sp. methanolic extract (LME) against DMH-induced cancer in adult male rats. Group (1) normal rats served as control, group (2) were ip-injected with LME at a dose 100 μg/kg/day, (3) animals, and (4) cancer-modeled animals treated (100 μg/kg/day) for six weeks. The results revealed that injection markedly regenerated pathophysiological disorders; this was monitored...
The objective of this research was to evaluate the cytotoxic activities fractions and isolated compounds soft corals Litophyton arboreum against A549, MCF-7 HepG2 cell lines by MTT assay method, chemically investigate various metabolites its total extract using LC-HR-ESI-MS metabolomic profiling. profiling revealed presence metabolites, mainly sesquiterpenes steroids reported for first time in L. arboreum. Additionally, eight (1-8) have been from n-hexane-chloroform (1:1) fraction that...
The ethyl acetate and dichloromethane-soluble fractions, from a soft coral Sarcophyton trocheliophorum total methanolic extract, exhibited significant anti-leishmanial cytotoxic activities. These active fractions yielded new cembranoid diterpene (1), two known analogues [sarcotrocheliol (2) sarcophine (3)], sterols [(24S)-24-methylcholesterol (4) gorgosterol (5)]. structure of the (1) was determined via detailed analysis its spectroscopic data. Compounds 3 5 demonstrated noticeable...
Three known compounds including, uracil (1), 5-methyl (2) and uridine (3) have been isolated from the soft coral Litophyton arboreum collected red sea. The were identified using spectroscopic techniques predominately 1H-NMR 13C-NMR analyses, in addition to HR-ESI-MS. Moreover, 1-3 vitro estimated for their cytotoxic activity against three human cancer cell lines (A549, MCF-7 HepG2), antileishmanial potential Leishmania major.
Abstract Background Echinometra mathaei (family Echinometridae), is one of the sea urchins widely distributed on Egyptian coasts in Red Sea. This organism contains edible and non-edible parts. The present study was carried out to analyze identify metabolites parts (Aristotle's lantern viscera) using LC/MS. Also, cytotoxic activity Vero cell line antiviral against herpes simplex virus type 1 were evaluated MTT colorimetric assay. Results Chemical profiling crude extracts Aristotle's viscera...
Abstract Parasites pose significant challenges to aquaculture and fisheries industries. Our study focuses on the Polyonchobothrium magnum African catfish address a potential health issue in aquaculture, explore host–parasite interactions that can help develop effective management practices ensure fish industry sustainability. P. was isolated from stomach of ( Clarias gariepinus ) as primary site infection, with prevalence 10%. Most affected were heavily infected (8 out 10). Infection...
Abstract Two new sesquiterpenes; 8α,11-dihydroxy-β-cyperon ( 2 ), and 5- epi -7α-hydroxy-( +)-oplopanone 3 were isolated from the soft coral Litophyton arboreum, together with nine known ones, including five 11-hydroxy-8-oxo-β-cyperon 1 alismoxide 4 5β,8β-epidioxy-11-hydroxy-6-eudesmene 5 chabrolidione B 6 7-oxo-tri-nor-eudesm-5-en-4β-ol 7 two sterols; 7β-acetoxy-24-methyl-cholesta-5,24(28)-diene-3β,19-diol 8 nebrosteroid M 9 glycerol derivatives; chimyl alcohol 10 ) batyl 11 ). The...
This study aimed to evaluate the chemical composition, fatty acid, amino and phytochemical profiles of three selected spices aromatic herbs i.e. fennel, caraway, chamomile. The assessed their potential as sources bioactive compounds. Various solvents, including distilled water, ethanol, methanol, acetone, were used extract these antioxidant activity (AOA) total phenolic content (TPC) extracts measured using in vitro methods. Significant differences observed composition chamomile powders,...
Cancer and infectious diseases are notoriously known as deleterious health threats for the world, especially in developing countries.The aim of present study was to evaluate cytotoxicity antimicrobial activities methanolic extracts soft corals Nephthea elatensis, Heteroxenia fuscescens, Ellisella juncea, Dendronephthya mollis, Sinularia hirta, that native Red Sea Egypt.The assay carried out by enzymatic reduction 3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromide (MTT) against...