A5047806242- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Botulinum Toxin and Related Neurological Disorders
- Glycogen Storage Diseases and Myoclonus
- Neurological and metabolic disorders
- Cardiovascular Syncope and Autonomic Disorders
- Mental Health Treatment and Access
- Balance, Gait, and Falls Prevention
- Coenzyme Q10 studies and effects
- Advanced MRI Techniques and Applications
- Ophthalmology and Eye Disorders
- Autism Spectrum Disorder Research
- Nuclear Receptors and Signaling
- Child and Adolescent Psychosocial and Emotional Development
- Mitochondrial Function and Pathology
- Obsessive-Compulsive Spectrum Disorders
- Epilepsy research and treatment
- Facial Rejuvenation and Surgery Techniques
- Pharmacological Effects and Toxicity Studies
- Cancer Treatment and Pharmacology
- Schizophrenia research and treatment
- Diversity and Career in Medicine
- Parkinson's Disease and Spinal Disorders
- Electroconvulsive Therapy Studies
University of Nebraska Medical Center
2016-2025
Baptist Health South Florida
2025
Florida International University
2023-2025
Brigham and Women's Hospital
2021
Oregon Health & Science University
2021
Children's Hospital of Richmond at VCU
2021
Geisinger Medical Center
2021
Duke Medical Center
2021
University of Pennsylvania
2021
Baylor College of Medicine
2021
Animal models and clinical studies have linked the innate adaptive immune system to pathology of Parkinson's disease (PD). Despite such progress, specific responses that influence progression eluded investigators. Herein, we assessed relationships between T cell phenotype function with PD progression. Peripheral blood lymphocytes from two separate cohorts, a discovery cohort validation cohort, totaling 113 patients 96 age- environment-matched caregivers were examined by flow cytometric...
Parkinson's disease (PD) is a neurodegenerative disorder associated with debilitating motor, posture, and gait abnormalities. Human studies recording local field potentials within the subthalamic nucleus scalp-based electroencephalography have shown pathological beta synchronization throughout cortical–basal ganglia motor network in PD. Suppression of such has been improved function, which may explain effectiveness deep-brain stimulation. We used magnetoencephalography (MEG) to investigate...
Evaluation of people with Parkinson's disease (PD) is often complex due to heterogeneity symptoms and course, including the variability motor fluctuations dyskinesia. Routine clinical evaluations may be incomplete, not accurately capture important symptoms, reflect day-to-day variability. While significant advances have been made in wearable ambulatory continuous objective monitoring (COM) technologies, many clinicians remain uncertain how incorporate them practice, value decision-making....
Determination of auditory function is a fundamental part complete neurologic examination. Disability from permanent hearing loss common in the general population. Current bedside tests are unreliable and cumbersome. We evaluated calibrated finger rub screening test (CALFRAST) as routine diagnostic tool.The sound spectrum mean peak intensities standard were measured, well background noise. CALFRAST overlapped frequency normal speech. Patients companions recruited neurology clinic. With arms...
Abstract Background The diagnosis of orthostatic tremor (OT) is challenging because its non‐specific symptoms and a broad range differential diagnosis, resulting in complex lengthy diagnostic journey. Objective aim was to assess the delay OT identify key clinical indicators as reported by patients. Methods In 2019, American community developed distributed web‐based survey titled “Symptoms Diagnosis Orthostatic Tremor (OT).” included questions on demographics, process, symptomatology. Results...
Abstract Background Orthostatic Tremor ( OT ) is characterized by the presence of a sensation instability while standing, associated with high frequency (13–18 Hz) lower extremity tremor. Diagnosis confirmed surface electromyography EMG ). An accurate screening tool that could be used in routine clinical setting, without any specialized equipment, would useful earlier detection and judicial use additional testing. Objective The objective this study was to evaluate diagnostic test...
To report a 2017 survey of all US medical school neurology clerkship directors (CDs) and to compare the results similar surveys conducted in 2005 2012.An American Academy Neurology (AAN) Consortium Clerkship Directors (CNCD) workgroup developed that was sent CDs listed AAN CNCD database. Comparisons were made 2012 surveys.The response rate 92 146 programs (63%). Among responding institutions, is required 94% schools 4 weeks length 75%. From 2017, clerkships shifted out fourth-year-only...
Bradykinesia in Parkinson's disease is a marker for clinical levodopa responsiveness, with persistent bradykinesia reflecting suboptimal response. We objectively measured prevalence and severity of morning using the Personal KinetiGraph® (PKG®).Retrospective evaluation large global database de-identified PKG assessments from individuals (N=12,840) routine care United States (US; n=3288). Median scores (mBKS) median dyskinesia (mDKS) were calculated validated algorithm previously established...
Abstract Background Limited tools are available for the assessment of orthostatic tremor severity and disability. Objectives To develop validate a self‐administered scale. Methods After expert consensus literature review generating list 42 items, scale was developed modified validation after patient focus group, multiple rounds Delphi panels, cognitive interviews. Clinimetric evaluations included assessing content validity, internal consistency, measurement error reliability, construct...
<strong>Background:</strong> The exact pathophysiology of primary Orthostatic Tremor (OT) is unknown. A central oscillator assumed, and previous imaging studies show involvement cerebellar pathways. However, the presence ataxia on clinical exam disputed. We set out to study in OT prospectively. <strong>Methods:</strong> EMG-confirmed subjects spousal controls received a neurological with additional semiquantitative evaluations as part multinational, prospective study. These included detailed...