A5064775232- MicroRNA in disease regulation
- Circular RNAs in diseases
- Mycorrhizal Fungi and Plant Interactions
- Cancer-related molecular mechanisms research
- Plant Parasitism and Resistance
- RNA Research and Splicing
- Ovarian cancer diagnosis and treatment
- Legume Nitrogen Fixing Symbiosis
- Plant Pathogens and Fungal Diseases
- RNA modifications and cancer
- Plant biochemistry and biosynthesis
- Horticultural and Viticultural Research
- RNA Interference and Gene Delivery
- Reproductive Biology and Fertility
- PARP inhibition in cancer therapy
- Advanced biosensing and bioanalysis techniques
- Cancer Risks and Factors
- Cancer Mechanisms and Therapy
- Plant and animal studies
- Plant and fungal interactions
- Viral-associated cancers and disorders
- Polyomavirus and related diseases
- Safe Handling of Antineoplastic Drugs
- Transplantation: Methods and Outcomes
- Intraperitoneal and Appendiceal Malignancies
Centre François Baclesse
2014-2025
Inserm
2015-2025
Normandie Université
2014-2025
Université de Caen Normandie
2014-2025
Centre François Baclesse
2020-2025
Onco Lille
2016-2025
Centre Hospitalier Universitaire de Caen Normandie
2022-2025
HES-SO University of Applied Sciences and Arts Western Switzerland
2021-2024
Centre Hospitalier Universitaire de Rouen
2024
Nutrition, Inflammation et axe Microbiote-Intestin-Cerveau
2024
Fungal symbiosis with early land plants Hundreds of millions years ago, evolved descendants aquatic began showing up on dry land. These newly terrestrialized species had to deal increased ultraviolet light exposure, desiccation, and less accessible nutrients. Rich et al. show how mutualist fungi may have helped these nascent plant lineages adaptation their challenging environment (see the Perspective by Bouwmeester). Genetic metabolic analysis a liverwort as representative such suggests that...
Temperature, water, solar radiation, and atmospheric CO 2 concentration are the main abiotic factors that changing in course of global warming. These govern synthesis degradation primary (sugars, amino acids, organic etc.) secondary (phenolic volatile flavor compounds their precursors) metabolites directly, via regulation biosynthetic pathways, or indirectly, effects on vine physiology phenology. Several hundred have been identified grape berry. Their biosynthesis characterized shown to...
Abstract We sought to identify miRNAs that can efficiently induce apoptosis in ovarian cancer cells by overcoming BCL-X L and MCL1 anti-apoptotic activity, using combined computational experimental approaches. found miR-491-5p induces IGROV1-R10 directly inhibiting expression inducing BIM accumulation its dephosphorylated form. This latter effect is due direct targeting of epidermal growth factor receptor (EGFR) consequent inhibition downstream AKT MAPK signalling pathways. Induction this...
Circulating miRNAs are promising biomarkers in oncology but have not yet been implemented the clinic given lack of concordance across studies. In order to increase cross-studies reliability, we attempted reduce and control circulating miRNA expression variability between patients. First, maximize profiling signals variability, three isolation kits were compared NucleoSpin(®) kit provided higher concentrations than other widely used kits. Second, inter-sample during step, exogenous...
Ovarian cancer (OC) is the leading cause of death in patients with gynecologic cancers. Due to late diagnosis and resistance chemotherapy, 5-year survival rate OC below 40%. We observed that UCA1, a lncRNA previously reported play an oncogenic role several malignancies, overexpressed chemoresistant cell line OAW42-R compared their chemotherapy-sensitive counterpart OAW42. Additionally, UCA1 overexpression was related poor prognosis two independent patient cohorts. Currently, molecular...
Purpose: The recent rise in the incidence of cancer younger adults has been described high-income countries. This study aimed to identify trends France among adolescent and young adult (AYA) population.
Abstract Novel therapeutic strategies are urgently required for the clinical management of chemoresistant ovarian carcinoma, which is most lethal gynecologic malignancies. miRNAs hold promise because they play a critical role in determining cell phenotype by regulating several hundreds targets, could constitute vulnerabilities cancer cells. A combination gain-of-function miRNA screening and real-time continuous monitoring allows identification with robust cytotoxic effects Focusing on...
There is an urgent need of precision medicine for ovarian cancer patients to identify who respond chemotherapy and PARP inhibitors, a therapy targeting homologous recombination deficiency (HRD). Here we established panel 37 long-term patient-derived tumor organoids (PDTO) models various histological subtypes from 224 demonstrated that they mimic the molecular characteristics original tumors. Screening chemotherapeutic drugs showed PDTO exhibit heterogeneous responses, response high-grade...
ABSTRACT Background and Aim De novo cancers after liver transplantation (LT) are major causes of complications mortality LT. No report was found in the literature on several successive (SSC). The aim this study to see if survival one or more different prognostic factors patients with cancer SSC Methods Using data from French national database, 114 who underwent LT between 1993 2012 were followed up until their death June 2016. Cox model performed analyze potential risk (cancer...
Abstract Background Identifying patients with high-grade serous ovarian cancer (HGSOC) who will respond to treatment remains a clinical challenge. We focused on miR-622, miRNA involved in the homologous recombination repair (HRR) pathway, and we assessed its predictive value serum prior first-line chemotherapy at relapse. Methods Serum miR-622 expression was platinum-based prospective multicenter study (miRNA Analysis, miRSA, NCT01391351) retrospective cohort (Biological Resource Center,...
Abstract Downy mildew (DM; Plasmopara viticola ) is amongst the most severe fungal diseases in viticulture and reason for majority of fungicide applications. To reduce synthetic copper-based fungicides, there an urgent need natural alternatives, which are being increasingly tested by industry research community. However, their mode action remains unclear. Therefore, our study aimed to investigate transcriptomic changes induced oregano essential oil vapour (OEOV) DM-infected grapevines. OEOV...
Background Ovarian cancer is rare with a poor prognosis and few established risk factors. Hormones reproductive factors significantly impact its development, suggesting potential link endocrine disrupters. Methods In the AGRICAN cohort, 59 391 female farmers completed data on lifelong agricultural exposures life. Cox models attained age as timescale (HR 95% CI) were used. The role of hormonal confounders was considered along specific time windows for exposure (childhood, puberty menopause)....
Abstract Background Ovarian cancer is the first cause of death from gynecological malignancies mainly due to development chemoresistance. Despite emergence PARP inhibitors, which have revolutionized therapeutic management some these ovarian cancers, 5-year overall survival rate remains around 45%. Therefore, it crucial develop new strategies, identify predictive biomarkers and predict response treatments. In this context, functional assays based on patient-derived tumor models could...
ABSTRACT Background The impact of geographical accessibility on cancer survival has been investigated in few studies, with most research focusing access to reference care centers, using overall mortality and limited specific sites. This study aims examine the association primary excess patients 10 frequent cancers France, while controlling for socioeconomic deprivation. Methods included a total 151,984 cases diagnosed common sites 21 French registries between 2013 2015. Access was estimated...
Two surgical techniques used for peritoneal metastasis involve a risk of exposure to antineoplastic drugs (ADs): hyperthermic intraperitoneal chemotherapy (HIPEC) and pressurized aerosol (PIPAC). The objective this study was assess the differences in perception, training, knowledge risks as well protection practices occupational exposures all worker categories.This descriptive study, led two hospitals from distant French regions, performed through face-to-face interview assessed handling ADs...
ABSTRACT Plants are the foundation of terrestrial ecosystems and their colonization land was facilitated by mutualistic associations with arbuscular mycorrhizal fungi. Following that founding event, plant diversification has led to emergence a tremendous diversity symbioses microorganisms, ranging from extracellular most intimate intracellular associations, where fungal or bacterial symbionts hosted inside cells. Through analysis 271 transcriptomes 122 genomes, we demonstrate common...
Ovarian cancer is the leading cause of death from gynecological malignancies worldwide, and innate or acquired chemoresistance ovarian cells major therapeutic failure. It has been demonstrated that concomitant inhibition Bcl-xL Mcl-1 anti-apoptotic activities able to trigger apoptosis in chemoresistant cells. In this context, siRNA-mediated Bcl‑xL constitutes an appealing strategy by which eliminate However, safest most efficient way vectorize siRNAs vivo still under debate. present study,...
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Epithelial ovarian cancers (EOCs) are a heterogeneous collection of malignancies, each with their own developmental origin, clinical behavior and molecular profile. With less than 5% EOC cases, mucinous carcinoma is rare form poor prognosis 5-year survival 11% for advanced stages (III/IV). At the early stages, these malignant forms clinically difficult to distinguish from borderline (15%) benign (80%) better due large size heterogeneity tumors. Improving diagnosis therefore challenge regard...
<title>Abstract</title> Defence priming of plants with natural products is extensively studied in the agricultural field to reduce use synthetic and copper-based pesticides. Previous studies have shown that Oregano essential oil vapour (OEOV) an effective agent against downy mildew (DM) grapevine (<italic>Vitis vinifera</italic> L. cv. Chasselas), activating different transcriptomic regulated defence mechanisms. In present study, we complement data metabolomic insights, confirming some...