A5100635321- Aortic aneurysm repair treatments
- Aortic Disease and Treatment Approaches
- Vascular Procedures and Complications
- Cerebrovascular and Carotid Artery Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Peripheral Artery Disease Management
- Infectious Aortic and Vascular Conditions
- Chronic Obstructive Pulmonary Disease (COPD) Research
- HIV Research and Treatment
- Cardiac Valve Diseases and Treatments
- Pediatric health and respiratory diseases
- HIV/AIDS drug development and treatment
- Congenital Heart Disease Studies
- Liver Disease Diagnosis and Treatment
- Obstructive Sleep Apnea Research
- Per- and polyfluoroalkyl substances research
- Cancer Genomics and Diagnostics
- Phytochemistry and Biological Activities
- Heme Oxygenase-1 and Carbon Monoxide
- Cardiac Structural Anomalies and Repair
- Sarcoma Diagnosis and Treatment
- Renal and Vascular Pathologies
- Renal cell carcinoma treatment
- HIV-related health complications and treatments
- Soft tissue tumors and treatment
Tianjin University of Traditional Chinese Medicine
2025
Bengbu Medical College
2022-2023
Peking University People's Hospital
2010-2022
National Institutes of Health
2010-2022
Ruijin Hospital
2022
Peking University
2010-2022
Shanghai Jiao Tong University
2022
Fourth Affiliated Hospital of Anhui Medical University
2022
Anhui Medical University
2022
Office of the Director
2022
Objective: In this study, we characterized elvitegravir activity in the context of raltegravir resistance mutations. Design: Using site-directed mutagenesis, generated recombinant integrase proteins and viruses harboring mutation to assess biochemical cellular presence such mutants. Methods: Recombinant were used gel-based assays. Antiviral data obtained with reporter a single-round infection using luciferase-based assay. Results: Although main pathways involving mutations at position 148...
Resistance to raltegravir (RAL), the first HIV-1 integrase (IN) inhibitor approved by FDA, involves three genetic pathways: IN mutations N155H, Q148H/R/K, and Y143H/R/C. Those are generally associated with secondary point mutations. The resulting mutant viruses show a high degree of resistance against RAL but somehow affected in their replication capacity. Clinical virological data indicate relevance combination G140S + Q148H because its limited impact on HIV very RAL. Here, we report how at...
Although undergoing antidepressant treatments, many patients continue to struggle with chronic depression episode. Seeking the potential biomarkers and establishing a predictive model of clinical improvements is vital optimize personalized management depression. Mounting evidence showed thyroid hormones changes are central leading paradigms Here, we conducted real-world based retrospective study using biochemical data 2086 depressive inpatients during period 2014-2020. We first performed...
This study investigated the protective effect of rutin on reproductive and blood–testis barrier (BTB) damage induced by perfluorooctanoic acid (PFOA) exposure. In this study, male ICR mice were randomly divided into three groups, Ctrl group (ddH2O, 5 mL/kg), PFOA (PFOA, 20 mg/kg/d, + mL/kg; rutin, mL/kg). Mice exposed to for 28 days gavage once daily in presence or absence rutin. Histopathological observations demonstrated that treatment during exposure can reduce structural testis...
The aim of this study was to determine levels awareness basic knowledge concerning control and prevention chronic obstructive pulmonary disease (COPD) among general practitioners (GPs) in a Shanghai suburb evaluate adherence GOLD guidelines primary care. All 593 practitioners, including rural urban community GPs at 15 care centers the Songjiang district Shanghai, were questioned, comprising 331 from communities 262 rural. Only 115 (19.4%) understood that COPD is categorized into acute...
In the present study, immunoproteomic analysis was utilized to systemically characterize global autoantibody profiles in autoimmune hepatitis (AIH). Sera from 21 patients with AIH and 15 healthy controls were analyzed for antibody reactivity against protein antigens of HepG2, a human hepatoma cell line. The lysates HepG2 cells separated by two-dimensional electrophoresis then immunoblotted each serum sample. Matrix-assisted laser desorption/ionization mass spectrometry or/and...
Pancreatic ductal adenocarcinoma (PDAC) is one of the rapidly growing forms pancreatic cancer with a poor prognosis and less than 5% 5-year survival rate. In this study, we characterized genetic signatures signaling pathways related to from PDAC, using parsimony phylogenetic algorithm. We applied algorithm analyze publicly available whole-genome in silico array analysis gene expression data set 25 early-stage human PDAC specimens. explain here that phylogenetics an evolutionary analytical...
Objective. This study has explored the application value of malignant tumor SPE growth factor (TSGF) combined with markers (TM) (TSGF + TM) in nuclear medicine imaging to identify prostate cancer osteonosus (PCO). Methods. A retrospective analysis for 70 patients and bone disease admitted our hospital was performed, 30 healthy persons same period were selected as control group, advantages disadvantages various examinations analyzed. All diagnosed PET whole body imaging. Suspicious lesions...
Atrial fibrillation (AF) is increasingly prevalent in chronic kidney disease (CKD) patients. The efficacy and safety of non-vitamin K antagonist oral anticoagulants (NOACs) AF CKD patients remains unknown. This systematic review meta-analysis will mainly assess net clinical benefit (NCB) property NOACs versus warfarin with by a pooled-analysis.
We investigated a new approach to dilation of stenotic lesions through the femoral vein-accessory hepatic vein-intrahepatic communicating branched vein-hepatic vein-inferior vena cava loop in two cases Budd-Chiari syndrome. For some selected patients, this represents an additional method increase technical success and decrease complications. The most commonly used approaches for endovascular treatment syndrome (BCS) are percutaneous transhepatic, (IVC)-hepatic vein (HV), jugular vein-IVC-HV....
Objective To investigate the safety and efficiency of three different double-channel chemotherapy regimens in treatment advanced colorectal cancer.Methods 60 cases cancer with definite pathological diagnosis were randomly divided into groups 20 per group:the CPT-11+DDP group,the raltitrexed+DDP group fluorouracil+DDP group.Every 21 days was one course treatment,all patients received at least 2 cycles treatment.The recent effect,PFS,mOS,toxicity quality life observed respectively.Results 40...
Objective To determine the feasibility of limb salvage with major vascular reconstruction for sarcomas extremities, focusing on early complications, oncological and functional outcomes.Methods Between August 2004 June 2009, 13 patients （mean age 38 years, range 14-63 years） underwent wide resection upper lower extremity to include involved arterial venous segments. 4 had bone 9 soft tissue sarcomas, 6 only artery replacement other 7 both vein. 8 resected vessels were reconstructed graft 5...
Objective To evaluate the results of thoracic endovascular aortic repair (TEVAR) for chronic type B dissection.Methods From September 2005 to January 2013,30 patients with dissection received TEVAR.All were followed 2-90 months [mean (33 ±25) months].Results All procedures finally achieved technical success.However,during TEVAR,there transient endoleaks in 8 including Ⅰ 3 patients,type Ⅱ 5 and persistent which are Ⅳ endoleaks.Type successfully managed during procedures.There was no mortality...
To investigate the causes,prevention and treatment of femoral artery puncture related complications caused by application resuscitative endovascular balloon occlusion aorta (REBOA) in resection pelvic sacral tumors.
Objective To understand awareness of basic knowledge on control and prevention for chronic obstructive pulmonary disease (COPD) among general practitioner in community health service centers. Methods Questionnaire survey was conducted 593 practitioners at 15 centers a district Shanghai the morning February 26, 2008. Results Five hundred forty-two ( 91.4% ) surveyed knew that can be abbreviated as COPD, 315 them (53.1%) thought they main contents Guidelines Prevention Control Chronic...