A5102862032- Genetic factors in colorectal cancer
- Breast Cancer Treatment Studies
- Rheumatoid Arthritis Research and Therapies
- Inflammasome and immune disorders
- Global Cancer Incidence and Screening
- Metabolism, Diabetes, and Cancer
- Cancer Immunotherapy and Biomarkers
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer Risks and Factors
- Colorectal Cancer Screening and Detection
- Spondyloarthritis Studies and Treatments
- Immune Response and Inflammation
- Multiple and Secondary Primary Cancers
- Helicobacter pylori-related gastroenterology studies
- Cardiac Health and Mental Health
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Health and Risk Factors
- Ferroptosis and cancer prognosis
- Colorectal Cancer Treatments and Studies
- Cancer, Lipids, and Metabolism
- Autophagy in Disease and Therapy
- Childhood Cancer Survivors' Quality of Life
- Genomics, phytochemicals, and oxidative stress
- Microscopic Colitis
- Immune cells in cancer
San Salvatore Hospital
2023-2024
University of L'Aquila
2022-2024
University of Modena and Reggio Emilia
2009-2018
Azienda Ospedaliero-Universitaria di Modena
2017
University of Genoa
2005
Accumulating evidence suggests that metformin, used as an antidiabetic drug, possesses anti-cancer properties. Metformin reduced the incidence and growth of experimental tumors in vivo. In a randomized clinical trial among nondiabetic patients, metformin treatment significantly decreased number aberrant crypt foci compared to untreated group with follow-up 1 month. our study, HT29 cells were treated graded concentrations 10 mM/25 mM/50 mM for 24/48 h. We performed immunofluorescence...
Abstract Colorectal mucosa is targeted by toxic agents, which can initiate or promote colon cancer. The mechanism of damage might be a focal irritation with loss normal epithelial cell barrier function. Genetic alterations in tumors may also affect host inflammatory response. aim this study was to define the extent inflammation colorectal mucosa, along carcinogenesis, and microsatellite stable unstable carcinomas. We collected 103 samples from 65 patients (35 cancer adenoma, 8 bowel...
Mitochondrial Lon protease (LonP1) is a multi-function enzyme that regulates mitochondrial functions in several human malignancies, including colorectal cancer (CRC). The mechanism(s) by which LonP1 contributes to carcinogenesis not fully understood. We found silencing leads severe impairment and apoptosis colon cell lines. Here, we investigate the role of functions, metabolism epithelial-mesenchymal transition (EMT) tumour cells metastasis. was almost absent normal mucosa, gradually...
To improve understanding of the preclinical stage colonic inflammation by exploring existence a link between early inflammatory changes in mucosa and systemic redox balance.Clinical characteristics, fasting blood draw, mucosal biopsies from right, left, sigmoid-rectum tracts collected 28 healthy individuals (14/14 males/females) who underwent colonoscopy. Myeloperoxidase (MPO) positive cells infiltrating specimens were assessed immunohistochemistry, patients divided into high or low MPO...
Promyelocytic leukemia zinc finger protein (PLZF) is a involved in various signaling, growth regulatory, and differentiation pathways, including development/function of some T cells. Here, we aimed at the detection PLZF during colorectal carcinogenesis, using immunofluorescence, evaluation colocalization with CD2 CD56 positive cells (T, γ δ , NK, NKT cells), confocal‐microscopy, along since its earliest stages, that is, dysplastic aberrant crypt foci (ACF). Furthermore, analyzed normal...
Abstract Human colorectal microadenomas are considered the earliest detectable premalignant lesions in colon. They can be identified as aggregates of enlarged crypts with thicker epithelial linings and elongated luminal openings on colonic mucosal surface after methylene blue staining observation under a dissecting microscope. Multiple lines evidence suggest that central role neoplastic development is played by inhibition apoptosis, followed disruption DNA repair. Understanding early...
Accumulating evidence suggests that metformin, used as an antidiabetic drug, possesses anticancer properties. Metformin reduced the incidence and growth of experimental tumors in vivo. In a randomized clinical trial among nondiabetic patients, metformin treatment significantly decreased number aberrant crypt foci compared to untreated group with follow-up 1 month. our study, HT29 cells were treated graded concentrations 10 mM/25 mM/50 mM, for 24/48 hours. We performed immunofluorescence...
Abstract To study the expression level of a panel pro/anti‐apoptotic factors and inflammation‐related receptors in chondral fragments from patients undergoing surgical treatment for intra‐articular calcaneal fractures, cartilage were retrieved fractures 20 subjected to treatment. Primary cultures performed using fractured control patients. Chondrocyte each patient groups immunofluorescence staining quantitatively analyzed under confocal microscopy. Proteins extracted cultured chondrocytes...
The flat foot in childhood is a condition frequently observed orthopedic practice but it still debated when and which patients surgical corrective treatment appropriate; recently, the application of poly-L-lactic-acid (PLLA) screws was proposed. present study investigates group 33 treated with PLLA expansion endorthesis order to evaluate deformity correction. Clinical radiological outcomes were correlated with: a) morphological characterization both before after being removed from patients,...
We purposed to evaluate the role of Th inducing POZ-Kruppel Factor (ThPOK), a transcriptional regulator T cell fate, in tumour-induced immune system plasticity colorectal carcinogenesis. The amounts CD4+, CD8+ and CD56+ ThPOK+ cells infiltrate normal mucosa (NM), dysplastic aberrant crypt foci (microadenomas, MA), earliest detectable lesions carcinogenesis, carcinomas (CRC), were measured, colocalization ThPOK with above-mentioned markers was evaluated using confocal microscopy....