A5044444045- Cellular transport and secretion
- Fungal and yeast genetics research
- Trypanosoma species research and implications
- Heat shock proteins research
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Hemoglobin structure and function
- Ginger and Zingiberaceae research
- Lipid Membrane Structure and Behavior
- Plant-Microbe Interactions and Immunity
- CRISPR and Genetic Engineering
- Protein Kinase Regulation and GTPase Signaling
- Toxin Mechanisms and Immunotoxins
- Biochemical Acid Research Studies
- Photosynthetic Processes and Mechanisms
- Coenzyme Q10 studies and effects
- Plant-based Medicinal Research
- Biochemical and Molecular Research
- Endoplasmic Reticulum Stress and Disease
- Heart Failure Treatment and Management
- Antifungal resistance and susceptibility
- Insect symbiosis and bacterial influences
- Microbial Metabolic Engineering and Bioproduction
- Pulmonary Hypertension Research and Treatments
Stanford University
2020-2024
Texas A&M University
2015-2023
Mangalayatan University
2019
Aligarh Muslim University
2019
Texas A&M Health Science Center
2018
Banaras Hindu University
2012
Abstract Translational control exerts immediate effect on the composition, abundance, and integrity of proteome. Ribosome-associated quality (RQC) handles ribosomes stalled at elongation termination steps translation, with ZNF598 in mammals Hel2 yeast serving as key sensors translation stalling coordinators downstream resolution collided ribosomes, removal faulty products. The physiological regulation RQC general particular multicellular settings is underexplored. Here we show that undergoes...
This study examines the impact of Learning and Development (L&D) opportunities on job performance, with a specific focus Business Process Organizations (BPOs) in Pakistan. While previous research has explored relationship between L&D employee performance developed economies, there remains lack empirical evidence Pakistani context. employs quantitative design, collecting data from 178 employees working BPOs Islamabad. Using regression mediation analyses, findings reveal that have...
Understanding cellular stress response pathways is challenging because of the complexity regulatory mechanisms and dynamics, which can vary with both time type stress. We developed a reverse genetic method called ReporterSeq to comprehensively identify genes regulating stress-induced transcription factor under multiple conditions in time-resolved manner. links RNA-encoded barcode levels pathway-specific output perturbations, allowing pooled pathway activity measurements via DNA sequencing...
Phosphatidylinositol-transfer proteins (PITPs) are key regulators of lipid signaling in eukaryotic cells. These both potentiate the activities phosphatidylinositol (PtdIns) 4-OH kinases and help channel production specific pools 4-phosphate (PtdIns(4)P) dedicated to biological outcomes. In this manner, PITPs represent a major contributor mechanisms by which outcomes phosphoinositide diversified. The two-ligand priming model proposes that engine Sec14-like PtdIns kinase is heterotypic...
Sec14-like phosphatidylinositol transfer proteins (PITPs) play important biological functions in integrating multiple aspects of intracellular lipid metabolism with phosphatidylinositol-4-phosphate signaling. As such, these offer new opportunities for highly selective chemical interference specific phosphoinositide pathways cells. The first and best characterized small molecule inhibitors the yeast PITP, Sec14, are nitrophenyl(4-(2-methoxyphenyl)piperazin-1-yl)methanones (NPPMs), a hallmark...
Yeast Sfh5 is an unusual member of the Sec14-like phosphatidylinositol transfer protein (PITP) family. Whereas PITPs are defined by their abilities to between membranes in vitro, and stimulate phosphoinositide signaling vivo, does not exhibit these activities. Rather, a redox-active penta-coordinate high spin Fe III hemoprotein with heme-binding arrangement that involves co-axial tyrosine/histidine coordination strategy complex electronic structure connecting open shell iron d -orbitals...
The ribosome-associated quality control (RQC) pathway resolves stalled ribosomes. As part of RQC, nascent polypeptide chains (NCs) are appended with CArboxy-Terminal amino acids (CAT tails) in an mRNA-free, non-canonical elongation process. CAT tail composition includes Ala, Thr, and potentially other residues. relationship between function has remained unknown. Using biochemical approaches yeast, we discovered that mechanochemical forces on the NC regulate tailing. We propose tailing...
The drug jadwar known as Delphinium denudatum Wall (Ranunculales: Ranunculaceae), the consist of dried tuberous roots D. denudatum. An annual glabrous or slightly downy herbs found is Western Himalayas from Kumaon to Kashmir at altitudes 3,000 m 4,500 specially on grassy slopes. It distinguished by its relatively small blue and violet color it one important drugs used indigenous medicine in India, especially where isolated petroleum ether-soluble fraction Jadwar widely traditional unani...
The paper aims to study a precise synopsis on the possible medical benefits of curcumin turmeric, ginger, and cinnamon histopathology liver kidney with Bcl-2 Bax, an apoptotic gene expression in diabetic -induced rats. It is establish statistical significance across studies that have conflicting results using herbal medicine. A qualitative meta-analysis search was executed following databases: PubMed, Science Direct, Google Scholar range 6 years (2017 - 2021) completed based effects...
The present study was designed to evaluate the protective effects of α-Lipoic acid alone and in combination with Ferulic Diabetic Nephropathy rats.Male albino rats were divided into different groups each group consists six rats.Nephropathy induced by administration STZ (60mg/kg, i.p).Rats observed for change body weight, kidney feed water intake.Nephropathy assessed evaluating Protein, albumin, urea, uric acid, creatinine (in urine) blood glucose level.Markers oxidative stress (Lipid...
The Phosphatidylinositol Transfer Proteins (PITPs) have emerged as central regulators of phosphoinositide signaling that diversify outcomes in cells. Sec14 is the prototype PITP S. cerevisiae with five homologs (Sfh1‐Sfh5) involved activities diverse trans‐ Golgi and lipid droplet metabolism to phosphatidylethanolamine ergosterol metabolism. Sfh5 an orphan member this family unknown function limited information about its genetic interactions or chemogenomic signatures. surface potential map...
Abstract Yeast Sfh5 is an unusual member of the Sec14-like phosphatidylinositol transfer protein (PITP) family. Whereas PITPs are defined by their abilities to between membranes in vitro, and stimulate phosphoinositide signaling vivo, does not exhibit these activities. Rather, a redox-active penta-coordinate high spin Fe III heme-binding with arrangement that involves co-axial tyrosine/histidine coordination strategy complex electronic structure connecting open shell iron d -orbitals three...