A5100606408- Renal Transplantation Outcomes and Treatments
- Traditional Chinese Medicine Analysis
- Medical Research and Treatments
- Liver Disease Diagnosis and Treatment
- Pharmacological Effects of Natural Compounds
- Pancreatitis Pathology and Treatment
- Diabetes and associated disorders
- Cardiac Ischemia and Reperfusion
- Immune cells in cancer
- Adipose Tissue and Metabolism
- Natural product bioactivities and synthesis
- Cancer Immunotherapy and Biomarkers
- Nitric Oxide and Endothelin Effects
- Plant-based Medicinal Research
- Neurological Disease Mechanisms and Treatments
- Cancer Cells and Metastasis
- Acute Ischemic Stroke Management
- HIV/AIDS drug development and treatment
- Bone Metabolism and Diseases
- Thyroid Disorders and Treatments
- Pharmacological Effects and Toxicity Studies
- Organ Transplantation Techniques and Outcomes
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Spinal Cord Injury Research
- Macrophage Migration Inhibitory Factor
Kanion Pharmaceutical (China)
2025
Southern Medical University
2006-2024
Nanfang Hospital
2020-2024
Changzhi Medical College
2024
Fujian Medical University
2024
Second Hospital of Anhui Medical University
2023
Chinese University of Hong Kong
2023
National Chung Cheng University
2023
Anhui Medical University
2023
Sichuan University
2003-2022
Taohe-Chengqi decoction (THCQ), a classical traditional Chinese medicinal (TCM) formula, has been extensively used for treating chronic kidney disease (CKD). However, the biological activity and mechanisms of action its constituents against renal fibrosis have not yet investigated thoroughly. This study was aimed at devising an integrated strategy investigating bioactivity possible pharmacological n-butanol extract THCQ (NE-THCQ) fibrosis. The prepared by solvent extraction method....
Abstract Background Cancer‐associated fibroblasts (CAFs), integral to the tumour microenvironment, are pivotal in cancer progression, exhibiting either pro‐tumourigenic or anti‐tumourigenic functions. Their inherent phenotypic and functional diversity allows for subdivision of CAFs into various subpopulations. While several classification systems have been suggested different types, a unified molecular on single‐cell pan‐cancer scale has yet be established. Methods We employed comprehensive...
Endothelial cells are thought to play a key role in sepsis pathogenesis: vascular endothelial damage occurs severe and multiple organ dysfunction. Soluble cadherin (VE-cadherin) levels were investigated prospective study involving 28 consecutive critically ill patients with or without who admitted surgical intensive care; 13 healthy age-matched volunteers included as controls. VE-cadherin increased significantly compared There was significant linear correlation between soluble illness...
Ischemic stroke (IS) is a globally life-threatening disease. Presently, few therapeutic medicines are available for treating IS, and rt-PA the only drug approved by US Food Drug Administration (FDA) in US. In fact, many agents showing excellent neuroprotection but no blood flow-improving activity animals have not achieved ideal clinical efficacy, while thrombolytic drugs improving flow without limited their wider application. To address these challenges meet huge unmet need, we designed...
The prevalence of subclinical hypothyroidism (SH) is increasing, especially in obese people. purpose this study was to evaluate the difference metabolic profiles between patients with mild increased thyrotropin (TSH) or normal TSH. A total 219 were recruited cross-sectional study. They divided into 2 groups: TSH (0.35-2.5 mU/l) and age-, body mass index (BMI)-matched higher-normal (2.5-5.5 mU/l). We have named it compensatory thyroid hormone deficiency. Anthropometric data, glucose-lipid...
Abstract The cytochrome P450 3As (CYP3As) are abundantly expressed in the liver and metabolize many commonly prescribed medications. Their expression is highly variable between individuals with little known genetic cause. Despite extensive investigation, cis‐acting elements that control of CYP3As remain uncharacterized. Using chromatin conformation capture (4C assays), we detected reciprocal interaction a distal regulatory region (DRR) CYP3A4 promoter. DRR colocalizes variety enhancer marks...
Purpose: The aim of this study was to analyze the effects various genetic polymorphisms and clinical factors on tacrolimus (TAC) concentration in convalescence period (CP) stabilization (SP) post-liver transplantation. Patients & methods: A total 13 SNPs were genotyped 97 Chinese liver transplant recipients. Associations between TAC trough blood concentration/dose ratio (C0/D) analyzed using different models both CP SP. Results: Only five significantly associated with log CP, none showed a...
Abstract Vascular endothelial cells play an important role in modulating anti-thrombus and maintaining the natural function of vascular by secreting many active substances. β-boswellic acid (β-BA) is triterpenoid compound from extract boswellia serrate. In this study, it demonstrated that β-BA ameliorates plasma coagulation parameters, protects endothelium blood stasis induced injury prevents impairment endothelium-dependent vasodilatation. Moreover, found significantly increases nitric...
10615 Background: The addition of H to a taxane provides significant clinical benefit, including prolonged survival, in HER2-positive MBC. adds little the toxicity taxanes alone. As monotherapy, X has consistently high activity and favorable safety. docetaxel extends survival Preliminary data [Bangemann et al. 2000] indicated that combination + is effective well-tolerated for intensively pretreated MBC (ORR 47%). current study evaluated efficacy safety first-line Methods: 72 pts planned...
Objective. The aim of this study is to observe the effect Peony‐Glycyrrhiza Decoction (PGD) on hyperprolactinemia in women with schizophrenia induced by Amisulpride. Material and Methods. A total 41 female patients receiving Amisulpride were randomly divided into placebo ( n = 20) PGD groups 21). Maintaining original dose, two given PGD, respectively. levels Prolactin (PRL) other hormones measured initial day at weeks 4 8 after treatment. Changes clinical symptoms observed. PANSS scores...
Cuproptosis plays a crucial role in cancer, and different subtypes of cuproptosis have immune profiles prostate adenocarcinoma (PRAD). This study aimed to investigate genes associated with develop risk model predict prognostic characteristics chemotherapy/immunotherapy responses patients PRAD.The CIBERSORT algorithm was used evaluate the stromal scores PRAD The Cancer Genome Atlas (TCGA) cohort. Validation differentially expressed DLAT DLD benign malignant tissues by immunohistochemistry,...
CYP3A4, CYP3A5, and CYP3A7, which are located in a multigene locus (CYP3A), play crucial roles drug metabolism. To understand the highly variable hepatic expression of CYP3As, regulatory network analyses have focused on transcription factors (TFs). Since long non-coding RNAs (lncRNAs) likely contribute to such networks, we assessed effects both TFs lncRNAs CYP3A human liver small intestine, main organs expression. Using weighted gene co-expression analysis (WGCNA) GTEx v8 RNA data multiple...
SUMMARY Information about the changing epidemiology of drug-resistant tuberculosis (TB) in hospitals China over past decade remains largely unknown. This study examined susceptibility patterns and trends TB cases 309 Hospital Beijing, China. Mycobacterium isolates were retrospectively identified, drug test (DST) results clinical data analysed for period 1997–2009. Of 5523 culture-positive patients, 47·1% had resistance to any anti-TB drug, 14·8% mono-resistant TB, 19·8% poly-resistant 19·4%...
Tacrolimus (TAC) is an immunosuppressant widely used in kidney transplantation. TAC displays considerable interindividual variability pharmacokinetics (PKs). Genetic and clinical factors play important roles PKs. We enrolled a total of 251 Chinese renal transplant recipients conducted genomewide association study (GWAS), linkage disequilibrium (LD), one-way analysis variance (ANOVA) to find genetic variants affecting log-transformed trough blood concentration/dose ratio (log[C