A5047384362- Genetic factors in colorectal cancer
- Hippo pathway signaling and YAP/TAZ
- FOXO transcription factor regulation
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- Fibroblast Growth Factor Research
- Single-cell and spatial transcriptomics
- Cancer Diagnosis and Treatment
- Viral-associated cancers and disorders
- Epigenetics and DNA Methylation
- BRCA gene mutations in cancer
- Metastasis and carcinoma case studies
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Immunotherapy and Biomarkers
- Cancer-related Molecular Pathways
- Kruppel-like factors research
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Neuroendocrine Tumor Research Advances
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Genomics and Diagnostics
- Nanoplatforms for cancer theranostics
- Ferroptosis and cancer prognosis
- Lymphoma Diagnosis and Treatment
- Cancer-related gene regulation
Chinese University of Hong Kong
2022-2025
Prince of Wales Hospital
2022-2025
Xiamen University
2023
Abstract Background Cancer‐associated fibroblasts (CAFs), integral to the tumour microenvironment, are pivotal in cancer progression, exhibiting either pro‐tumourigenic or anti‐tumourigenic functions. Their inherent phenotypic and functional diversity allows for subdivision of CAFs into various subpopulations. While several classification systems have been suggested different types, a unified molecular on single‐cell pan‐cancer scale has yet be established. Methods We employed comprehensive...
Abstract Background Gastric cancer (GC) is one of the most common tumours in East Asia countries and associated with Helicobacter pylori infection. H. utilizes virulence factors, CagA VacA, to up‐regulate pro‐inflammatory cytokines activate NF‐κB signaling. Meanwhile, PIEZO1 upregulation cancer‐associated fibroblast (CAF) enrichment were found GC progression. However, mechanisms its involvement progression have not been fully elucidated. Methods The CAF clinical significance investigated...
Tumor-associated macrophages (TAMs) is a key element in the breast tumor microenvironment. CD163 and CD206 have been utilized for TAM identification, but clinical implications of TAMs identified by these markers not thoroughly explored. This study conducted comparative analysis using digital image analysis, focusing on their spatial distribution prognostic significance relation to tumor-infiltrating lymphocytes (TILs). Distinct clinico-pathological characteristics were noted between two...
ABSTRACT Background Gastric cancer (GC) is a major health concern worldwide. One important contributing factor the presence of Epstein‐Barr virus (EBV). However, molecular pattern how EBV participates in malignant transition process remains unclear. Methods GC samples were stained by immunohistochemistry, fluorescent and EBV‐encoded small RNA situ hybridization to identify CD8 expression, CDKN2A genomic alteration, existence. Functional potentials infection predicted bioinformatic enrichment...
Abstract The Hippo–YAP1 pathway is an evolutionally conserved signaling cascade that controls organ size and tissue regeneration. Dysregulation of promotes initiation progression several types cancer, including gastric cancer. As the regulates expression thousands genes, it important to establish which target genes contribute oncogenic program driven by YAP1 identify strategies circumvent it. In this study, we identified a vital role forkhead box protein 4 (FOXP4) in YAP1-driven...
Abstract Background: The epigenetic modification of LncRNA N6-methyladenosine (m6A) methylation plays a wide role in the invasion and metastasis various malignant tumors. However, LncRNA-ATB m6A colorectal cancer (CRC) has not been systematically elucidated. Methods: Detect regulatory effect ALKBH5 on by Luciferin reporter gene. expression was detected IHC qPCR CRC tissues cells. Transwell scratch tests were used to detect overexpression after knockdown replacement migration ability Western...
<p>Supplementary Figure S2</p>
<p>Supplementary Figure S13</p>
<p>Supplementary Figure S10</p>
<p>Supplementary Table S1-S4</p>
<p>Supplementary Figure S12</p>
The most common sites of metastasis for breast cancer are the soft tissues, bones, lungs, liver and brain; however, metastases to gastrointestinal tract thyroid gland from rarely occur. present study describes case a 30-year-old woman who developed gastric 5 years after her initial diagnosis invasive ductal carcinoma. pathological when receiving modified radical mastectomy was carcinoma, further immunohistochemical examination revealed be estrogen receptor (-), progesterone human epidermal...
Abstract A fibrotic focus (FF) is a scar-like region that forms in the center of carcinoma due to excessive tumor stroma formation. In our earlier studies, we found FF as an independent poor prognostic factor for breast cancers. However, underlying mechanisms how presence contributed prognosis are still unknown. To improve understanding cancer, have investigated genes associated with and their impacts on cancer prognosis. Analysis data from The Cancer Genome Atlas Program (TCGA) indicated...
<p>Supplementary Figure S7</p>
<p>Supplementary Figure S8</p>
<p>Supplementary Figure S6</p>
<p>Supplementary Figure S14</p>
<p>Supplementary Figure S1</p>
<p>Supplementary Figure S3</p>
<p>Supplementary Figure S11</p>
<p>Supplementary Figure S9</p>
<p>Supplementary Figure S5</p>
<p>Supplementary Figure S4</p>
<div>Abstract<p>The Hippo–YAP1 pathway is an evolutionally conserved signaling cascade that controls organ size and tissue regeneration. Dysregulation of promotes initiation progression several types cancer, including gastric cancer. As the regulates expression thousands genes, it important to establish which target genes contribute oncogenic program driven by YAP1 identify strategies circumvent it. In this study, we identified a vital role forkhead box protein 4 (FOXP4) in...