A5100357018- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- RNA Research and Splicing
- Circular RNAs in diseases
- Spine and Intervertebral Disc Pathology
- Ferroptosis and cancer prognosis
- Cancer Diagnosis and Treatment
- interferon and immune responses
- Congenital heart defects research
- Genetically Modified Organisms Research
- AI in cancer detection
- 3D Printing in Biomedical Research
- Pelvic and Acetabular Injuries
- Bone and Dental Protein Studies
- Cancer Genomics and Diagnostics
- Spinal Fractures and Fixation Techniques
- Bone Tissue Engineering Materials
- Pharmaceutical and Antibiotic Environmental Impacts
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Genomic variations and chromosomal abnormalities
- Genetic and phenotypic traits in livestock
- Tissue Engineering and Regenerative Medicine
- Colorectal Cancer Screening and Detection
- Genomics and Rare Diseases
Harbin Medical University
2022-2025
Third Affiliated Hospital of Harbin Medical University
2022-2025
Huazhong Agricultural University
2025
Chengdu Women's and Children's Central Hospital
2024
Chengdu Medical College
2024
Xuzhou Medical College
2022-2023
Beijing Hospital of Traditional Chinese Medicine
2022
Capital Medical University
2020-2022
Broad Institute
2021
Foshan University
2021
Breast cancer is one of the leading causes cancer-associated mortality in women worldwide and has become a major public health problem. Although definitive cause breast not known, many genes sensitive to have been detected using advanced technologies. Our study identified 3301 differentially expressed lncRNAs mRNAs between tumor normal samples from The Cancer Genome Atlas database. Based on gene expression analysis clinical traits as well weighted co-expression network analysis, Brown module...
298 Background: The current TNM staging system fails to provide adequate information for prognosis and adjuvant chemotherapy benefits in colorectal cancer (CRC). Pathomics, an emerging field, shows promise improving estimation decision-making. In this study, we developed validated a pathomics signature (PS CRC ) that directly analyzes hematoxylin eosin–stained slides using deep learning predict outcomes. Methods: A total of 883 whole slide images from two cohorts, Harbin Medical University...
Bladder cancer (BC) is a highly prevalent form of the genitourinary system; however, effective biomarkers are still ambiguous and deserve deeper investigation. Long non-coding RNA (lncRNA) occupies prominent position in tumor biology immunology, ferroptosis-related genes participate regulatory processes cancer. In this study, 538 differentially expressed lncRNAs were identified from The Cancer Genome Atlas database through co-expression method differential expression analysis. Then, samples...
Numerous risk factors for oesophageal cancer are linked to lifestyle habits, but the role of early-life in its incidence and mortality is unclear. Using UK Biobank data, we explore association among breastfeeding, maternal smoking, smoking offspring, adult offspring via multivariable Cox regression. Here, show that being breastfed, compared with not associated a lower (HR: 0.83, 95% CI: 0.70–0.98) 0.74, 0.61–0.89) offspring. Additionally, it reduced impact on 0.79, 0.64-0.96) 0.73,...
The mechanisms underlying the proliferation and apoptosis of glioma cells remain unelucidated. A recent study has revealed that microRNA-92b (miR-92b) inhibits via downregulating DKK3. Notably, long noncoding RNA nuclear-enriched abundant transcript 1 (NEAT1) is predicted to have a possible interaction with miR-92b.This aimed identify whether NEAT1 affects cell regulating miR-92b.The expression was compared between tissues adjacent as well normal astrocytes using quantitative real-time...
Research has shown that long-chain noncoding RNAs (lncRNAs) are involved in the regulation of a variety biological processes, including peripheral nerve regeneration, part by acting as competing endogenous RNAs. c-Jun plays key role repair injury. However, precise underlying mechanism remains unclear. In this study, we performed microarray and bioinformatics analysis mouse crush-injured sciatic nerves found lncRNA Pvt1 was overexpressed Schwann cells after Mechanistic studies revealed...
Bone defects have long been a major healthcare issue because of the difficulties in regenerating bone mass volume and high cost treatment. G protein-coupled receptor kinase 2 interacting protein 1 (GIT1) has proven to play an important role both vascular development fracture healing. In this study, type thermoresponsive injectable hydrogel from oligoethylene glycol-based dendronized chitosan (G1-CS) was loaded with GIT1-plasmids (G1-CS/GIT1), used fill unicortical defects. RT-PCR analysis...
Recurrence of lumbar disc herniation (LDH) is an adverse event after percutaneous endoscopic transforaminal discectomy (PETD). Accurate prediction the risk recurrent LDH (rLDH) surgery remains a major challenge for spine surgeons.To develop and validate prognostic model based on factors rLDH PETD.Retrospective study.Inpatient center.Clinical data were retrospectively collected from 645 patients with who underwent PETD at Affiliated Hospital Xuzhou Medical University January 1, 2017 to 2021....
The blue egg is both of biological interest and economic importance for consumers, retailers, scientists. To date, the genetic mechanisms underlying pigment have mainly focused on protein-coding genes. However, underpinning mechanism non-coding RNAs deposition among different eggshell colors remains unknown. In this study, RNA sequencing was employed to profile uterine gland transcriptome (lncRNA mRNA) 15 Changshun layers, better understand color. Results showed that differentially expressed...
The neuroendocrine-immune (NEI) network is fundamental for maintaining body's homeostasis and health. While the roles of microRNAs (miRNAs) transcription factors (TFs) in disease processes are well-established, their synergistic regulation within NEI has yet to be elucidated. In this study, we constructed a background NEI-related miRNA-TF regulatory (NEI-miRTF-N) by integrating signaling molecules (including miRNAs, genes, TFs) identifying feed-forward loops. Our analysis reveals that number...
Pure partial trisomy 16q12.1q22.1 is a rare chromosome copy number variant (CNV). The primary clinical phenotypes associated with this syndrome include abnormal facial morphology, global developmental delay (GDD), short stature, and reported predisposing factors for atypical behavior, autism, the development of learning disabilities, neuropsychiatric disorders. dosage-sensitive genes are not disclosed preventing to establish genotype-phenotype correlation. We report case Chinese patient...
Background: With a high incidence and dismal survival rate, hepatocellular carcinoma (HCC) tops the list of world’s most frequent malignant tumors. Immunotherapy is new approach to cancer treatment, its effect on prolonging overall (OS) varies from patient patient. For more effective prognosis treatment HCC, we are committed identifying immune infiltration-related long non-coding RNAs (IIRLs) with prognostic value in carcinoma. Methods: In our study, calculated scores 369 samples Cancer...
Bone defects have long been a major healthcare issue because of the difficulties in regenerating mass bone volume and high cost treatment. G protein-coupled receptor kinase 2 interacting protein 1 (GIT1) has proven to play an important role both vascular development fracture healing. In this study, type thermoresponsive injectable hydrogel from oligoethylene glycol-based dendronized chitosan (G1-CS) was loaded with GIT1-plasmids (G1-CS/GIT1), used fill unicortical defects. RT-PCR analysis...
To develop a bidirectional slide guide to assist screw placement in the axial lamina and preliminarily discuss accuracy feasibility of auxiliary placement.CT data from 40 randomly selected patients were imported into software for modelling, cross-pinning was used simulate pinning. According different crossing methods upper lower laminar screws, they are divided two groups. In software, position needlepoint each is accurately measured, needle point kept unchanged movable range tail under...
e14537 Background: Nasopharyngeal carcinoma (NPC) is one of the most prevalent malignancies among populations native to Southeast Asia, Mediterranean Basin and Arctic. Early diagnosis NPC predicted improve survival. The identification cancer-specific DNA methylation patterns cell-free (cfDNA) isolated from blood samples an established approach for detecting various cancers. In present study, we evaluated performance characteristics a previously identified marker panel nasopharyngeal...
Abstract BackgroundThe molecular mechanism of bone metastasis in breast cancer is largely unknown. We aimed to find key genes and long noncoding RNAs (lncRNAs) related the using a bioinformatic approach. MethodsWe downloaded gene expression data (GSE66206) probe annotation files from public database Gene Expression Omnibus. Then, we analyzed network nodes core driver genes. Weighted correlation analysis was performed on profile identify potential pathogenic modules. function pathway...
Abstract Background: The molecular mechanism of bone metastasis in breast cancer is largely unknown. We aimed to find key genes and long noncoding RNAs (lncRNAs) related the using a bioinformatic approach. Methods: downloaded gene expression data (GSE66206) probe annotation files from public database Gene Expression Omnibus. Then, we analyzed network nodes core driver genes. Weighted correlation analysis was performed on profile identify potential pathogenic modules. function pathway...