A5030401184- Infant Development and Preterm Care
- Traumatic Brain Injury Research
- Anesthesia and Neurotoxicity Research
- Anesthesia and Sedative Agents
- Child Abuse and Trauma
- Cerebral Palsy and Movement Disorders
- Family and Disability Support Research
- Pediatric Pain Management Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Arrest and Resuscitation
- Child and Adolescent Psychosocial and Emotional Development
- Glioma Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Neonatal and fetal brain pathology
- Anesthesia and Pain Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Growth Hormone and Insulin-like Growth Factors
- Posttraumatic Stress Disorder Research
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Alzheimer's disease research and treatments
- Music Therapy and Health
- Migration, Health and Trauma
- Healthcare Decision-Making and Restraints
- Early Childhood Education and Development
- Pituitary Gland Disorders and Treatments
La Trobe University
2011-2025
Université Bourgogne Franche-Comté
2025
Murdoch Children's Research Institute
2006-2019
Royal Children's Hospital
1999-2019
The University of Melbourne
1990-2015
Austin Health
2010-2012
Austin Hospital
2007
Baylor College of Medicine
2005
St. Jude Children's Research Hospital
2005
Children's Cancer Center
2005
BackgroundIn laboratory animals, exposure to most general anaesthetics leads neurotoxicity manifested by neuronal cell death and abnormal behaviour cognition. Some large human cohort studies have shown an association between anaesthesia at a young age subsequent neurodevelopmental deficits, but these are prone bias. Others found no evidence for association. We aimed establish whether in early infancy affects outcomes.MethodsIn this international, assessor-masked, equivalence, randomised,...
This prospective, longitudinal study examined the effects of risk-adapted craniospinal irradiation (CSI) dose and interactions with age time from diagnosis on intelligence quotient (IQ) academic achievement (reading, spelling, math) among patients treated for medulloblastoma (MB).Patients received serial neurocognitive testing spanning 0 to 6.03 years after (median, 3.14 years). The multi-institutional included 111 patients, who were 3 20 at (median age, 7.4 years), MB CSI followed by four...
Postoperative apnea is a complication in young infants. Awake regional anesthesia (RA) may reduce the risk; however, evidence weak. The General Anesthesia compared to Spinal study randomized, controlled trial designed assess influence of general (GA) on neurodevelopment. A secondary aim compare rates after anesthesia.Infants aged 60 weeks or younger, postmenstrual age scheduled for inguinal herniorrhaphy, were randomized RA GA. Exclusion criteria included risk factors adverse...
In Brief During routine adult anesthesia, the risk of awareness is 0.1%–0.2%. No recent studies have reported incidence in children. Altered pharmacology and differing anesthesia techniques suggest that may differ this prospective cohort study, we determined during Eight-hundred-sixty-four children aged 5–12 yr who had undergone general at The Royal Children's Hospital were interviewed on 3 occasions to determine awareness. assessment was nested within a larger study behavior change after...
Using prospective longitudinal data from 198 very preterm and 70 full term children, this study characterised the memory learning abilities of children at 7 years age in both verbal visual domains. The relationship between extent brain abnormalities on neonatal magnetic resonance imaging (MRI) outcomes was also investigated. Neonatal MRI scans were qualitatively assessed for global, white-matter, cortical grey-matter, deep cerebellar abnormalities. Very performed less well measures immediate...
Engagement with traditional mental health services can be particularly challenging for young people experiencing severe and complex problems. Assertive community treatment-based providing mobile outreach, such as Intensive Mobile Youth Outreach Services (IMYOS), operate across Australia to support these people's needs in the transition adulthood. Past research on IMYOS has focused quantitative outcome measures, experiences of this type model are poorly understood. This study explored youth...
Summary Background : In children anxiety at induction of anesthesia is a common and important aspect the psychological impact surgery. Previous studies examining risk factors for increased have found contradictory results. This may be due to using small, or highly selective population samples, failure adjust confounding variables. Results also culturally institutionally specific. The aim this study was identify possible in large representative cohort children. Methods One thousand two...
Abstract Neuropsychological measures were administered to 18 patients with anorexia nervosa shortly after admission hospital and again substantial weight gain. These compared a group of normal controls, also tested on two occasions, who matched for age, sex, estimated premorbid IQ. At low weight, impairment was evident tests attentional-perceptual-motor functions visuospatial construction problem-solving. Learning less affected. Refeeding resulted in significant improvements performance.
<i>Objective:</i> To examine the relative contributions of injury severity, level physical and cognitive disability, child behavior family function to short-term outcome 6 months following traumatic brain (TBI) in children. <i>Design:</i> Prospective, longitudinal, between-group design, comparing preinjury postinjury measures functional across three levels severity. <i>Subjects:</i> One hundred twelve children, aged 2–12 years admitted Royal Children’s...
Summary Background: Hospitalization and anesthesia can have a substantial psychological impact on children, which may be manifested by negative behavioral change. The primary aims of this study were to estimate the incidence behavior change postanesthesia in large cohort identify possible risk factors. Methods: One thousand two hundred fifty children aged from 3 12 years scheduled for variety procedures enrolled. absolute version Vernon Post Behavior Questionnaire (PHBQ) was used assess at...
Emergence delirium (ED) frequently occurs in young children awakening from general anesthesia (GA). To date, research is limited by scales that are unable to discriminate the condition other forms of agitation.The primary aim this study was determine core behaviors ED pain and tantrum cluster these according DSM-IV/V diagnostic criteria associated delirium.Children aged 18 months 6 years (n=198) were observed upon GA following surgical or nonsurgical procedures which categorize ED. Behaviors...
This study evaluated the effectiveness of a multisystemic early intervention that included comparison an emotion- and behavior-focused parenting program for children with emerging conduct problems. The processes moderated positive child outcomes were also explored. A repeated measures cluster randomized group design methodology was employed three conditions (Tuning in to Kids, Positive Parenting Program, waitlist control) two periods (preintervention 6-month follow-up). sample consisted 320...
The effects of prematurity on hippocampal development through early childhood are largely unknown. aims this study were to (1) compare the shape very preterm (VPT) hippocampus that full-term (FT) children at 7 years age, and determine if is associated with memory learning impairment in VPT children, (2) change volume hippocampi from term-equivalent age between FT over time predicts children. T1 T2 magnetic resonance images acquired both term equivalent 125 25 Hippocampi manually segmented...
Abstract Using magnetic resonance imaging, this study compared hippocampal volume between 145 very preterm children and 34 born full-term at 7 years of age. The relationship memory learning impairments was also investigated. Manual segmentation subsequent three-dimensional volumetric analysis revealed reduced volumes in with term peers. However, did not remain after correcting for whole brain neonatal abnormality. Contrary to expectations, the cohort related outcomes. Further research...
Cognitive deficits are frequently reported in children treated for posterior fossa (PF) tumors. A range of tumor, treatment, medical and treatment complications have been implicated causing a variety cognitive deficits. The aim this study is to identify factors that influence intelligence, attention information processing these children. Thirty-five (aged 4-16) with PF tumors attending the Royal Children's Hospital Melbourne, Australia, were enrolled into prospective, repeated measures...
This study investigated long-term executive functioning following early mild traumatic brain injury (TBI), differentiating between complicated (n=34) and uncomplicated injuries (n=18). Children post TBI were compared to 33 controls at least 7-years post-injury. The group performed significantly worse on divided attention both groups, with younger age neurological symptoms predictors of outcome. No significant differences existed speed information processing, selective attention, working...
Little is known about specific attentional sequelae following a closed head injury, their pattern of recovery or interaction with ongoing development. The present study examined abilities in group children who had sustained mild, moderate, severe injury. Results showed that the injury exhibited greater deficits on number measures at acute and 6 months postinjury phases, comparison to mild moderate groups. Specifically, were most evident timed tasks where speed processing was an integral...
Article Health Related Quality of Life and Psychological Outcome in Patients Treated for Craniopharyngioma Childhood was published on January 1, 2006 the journal Journal Pediatric Endocrinology Metabolism (volume 19, issue 1).
<b><i>Backgroud/Aims:</i></b> Poor quality of life (QoL) has been reported in adults with growth hormone deficiency. Few studies have examined QoL childhood onset multiple pituitary deficiencies (COMPHD). We evaluated COMPHD. <b><i>Methods:</i></b> COMPHD participants aged ≥18 years were identified from hospital medical records and the clinics one author (M.Z.). Age- sex-matched controls recruited for every participant. The World Health...