Agnes I. Hunyady
A5037367471- Airway Management and Intubation Techniques
- Tracheal and airway disorders
- Neuropeptides and Animal Physiology
- Foreign Body Medical Cases
- Pain Mechanisms and Treatments
- Respiratory Support and Mechanisms
- Receptor Mechanisms and Signaling
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Sedative Agents
- Pharmacological Receptor Mechanisms and Effects
- Ion Channels and Receptors
- Anesthesia and Neurotoxicity Research
- Cancer, Stress, Anesthesia, and Immune Response
- Congenital Ear and Nasal Anomalies
- Nerve injury and regeneration
- Neurosurgical Procedures and Complications
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Biochemical Analysis and Sensing Techniques
- Peptidase Inhibition and Analysis
- Liver Disease and Transplantation
- Infection Control and Ventilation
- Appendicitis Diagnosis and Management
- Pharmacological Effects of Natural Compounds
- Intracerebral and Subarachnoid Hemorrhage Research
- Spinal Hematomas and Complications
Seattle Children's Hospital
2012-2025
University of Washington
2012-2025
University of Pecs
2017-2023
Toscana Life Sciences
2023
University of Washington Medical Center
2015
Eastern Maine Medical Center
2008
Albany Medical Center Hospital
2006
BackgroundIn laboratory animals, exposure to most general anaesthetics leads neurotoxicity manifested by neuronal cell death and abnormal behaviour cognition. Some large human cohort studies have shown an association between anaesthesia at a young age subsequent neurodevelopmental deficits, but these are prone bias. Others found no evidence for association. We aimed establish whether in early infancy affects outcomes.MethodsIn this international, assessor-masked, equivalence, randomised,...
Flexible bronchoscopy is the gold standard for difficult airway management. Clinicians are using videolaryngoscopy increasingly because it perceived to be easier use with high success rates. We conducted this study compare rates of two techniques when used after failed direct laryngoscopy in children tracheal intubations. identified cases where initial attempts at multicentre Pediatric Difficult Intubation Registry from August 2012-September 2023. After propensity score matching, we compared...
We analysed data from the Paediatric Difficult Intubation Registry examining use of direct laryngoscopy and GlideScope® videolaryngoscopy.Data collected by a multicentre, paediatric difficult intubation registry 1295 patients were analysed. Rates success complications between GlideScope videolaryngoscopy analysed.Initial (464/877 = 53% vs 33/828 4%, Z-test 22.2, P < 0.001) eventual (720/877 82% vs. 174/828 21%, 25.2, rates for significantly higher than laryngoscopy. Children weighing <10 kg...
Chronic stress causes several pain conditions including fibromyalgia. Its pathophysiological mechanisms are unknown, and the therapy is unresolved. Since involvement of interleukin-1 (IL-1) has been described in inflammatory but no data available regarding stress-induced pain, we studied its role a chronic restraint (CRS) mouse model. Female male C57Bl/6J wild-type (WT) IL-1αβ-deficient (knock-out: IL-1 KO) mice were exposed to 6 h immobilization/day for 4 weeks. Mechanonociception, cold...
BackgroundDifficult facemask ventilation is perilous in children whose tracheas are difficult to intubate. We hypothesised that certain physical characteristics and anaesthetic factors associated with mask paediatric patients who also had tracheal intubation.MethodsWe queried a multicentre registry for experienced "difficult" or "impossible" ventilation. Patient case known before attempt were included consideration this regularised multivariable regression analysis. Incidence of...
BackgroundThe Paediatric Difficult Intubation Collaborative identified multiple attempts and persistence with direct laryngoscopy as risk factors for complications in children difficult tracheal intubations subsequently engaged initiatives to reduce repeated children. We hypothesised these efforts would lead fewer attempts, decrease complications.MethodsPaediatric patients less than 18 years of age were enrolled the Registry. define those whom (1) an attending or consultant obtained a...
Abstract Background Clinical studies demonstrated peripheral nociceptor deficit in stress‐related chronic pain states, such as fibromyalgia. The interactions of stress and nociceptive systems have special relevance pain, but the underlying mechanisms including role specific populations remain unknown. We investigated capsaicin‐sensitive neurones changes. Method Capsaicin‐sensitive were desensitized by capsaicin analogue resiniferatoxin ( RTX ) CD 1 mice. effects desensitization on restraint...
Expression of the transient receptor potential ankyrin 1 (TRPA1) has been demonstrated not only in dorsal root and trigeminal ganglia but also different brain regions (e.g., hippocampus, hypothalamus, cortex). However, data concerning their role neurodegenerative age-related diseases CNS is still indistinct. The aim our study was to investigate TRPA1 a mouse model senile dementia. For investigation changes during aging, we used male young (3–4-month-old) old (18-month-old) wild-type...
Somatostatin released from the capsaicin-sensitive sensory nerves mediates analgesic and anti-inflammatory effects via somatostatin sst4 receptor without endocrine actions. Therefore, is considered to be a novel target for drug development in pain including chronic neuropathy, which an emerging unmet medical need. Here, we examined silico binding, sst4-linked G-protein activation on stable expressing cells (1 nM 10 μM), of our pyrrolo-pyrimidine molecules mouse inflammatory neuropathic...
Knowledge of normal front teeth-to-carina distance (FT-C) might prevent accidental bronchial intubation. The aim the current study was to measure FT-C and examine whether Morgan formula for oral intubation depth, i.e., endotracheal tube (ETT) position at teeth (cm) = 0.10 x height + 5, gives appropriate guidance when intubating children different ages.FT-C measured in 170 infants children, aged 1 day 19 yr, undergoing cardiac catheterization. obtained as sum ETT length upper teeth/dental...
The Tac4 gene-derived hemokinin-1 (HK-1) is present in pain-related regions and activates the tachykinin NK1 receptor, but with binding site signaling pathways different from Substance P (SP). receptor involved nociception, our earlier data showed that it has no role chronic neuropathic hyperalgesia, similarly to SP. Furthermore, antagonists failed clinical trials as analgesics due still unknown reasons. Therefore, we investigated of HK-1 pain conditions distinct mechanisms using genetically...
Opioid use is common and associated with side effects risks. Consequently, analgesic strategies to reduce opioid utilization have been developed. Regional anesthesia multimodal are central tenets of enhanced recovery pathways facilitate reduced perioperative use. Opioid-free (OFA) protocols eliminate all intraoperative opioids, reserving opioids for postoperative rescue treatment. Systematic reviews show variable results OFA.In a series Quality Improvement (QI) projects, multidisciplinary...
The aim of the study was to examine different brands preformed oral and nasal endotracheal tubes (ETT) assess whether bend placement gave acceptable guidance for ETT depth positioning in children.The distance from vertex tip (bend-to-tip distance) seven ETTs were measured. Front teeth-to-carina (FTC) nares-to-carina (NC) data orally (0-19 years) nasally (0-8 intubated children used risk endobronchial intubation if a had been placed with its at front teeth or nares.While bend-to-tip cuffed...
Numerous in vitro and vivo models of Parkinson's disease (PD) demonstrate that pituitary adenylate cyclase-activating polypeptide (PACAP) conveys its strong neuroprotective actions mainly via specific PAC1 receptor (PAC1R) PD. We recently described the decrease PAC1R protein content basal ganglia macaques 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model PD was partially reversed by levodopa therapy. In this work, we tested whether these observations occur also rotenone rat. The...
Abstract Background We investigated how syndromic versus nonsyndromic forms of micrognathia impacted difficult intubation outcomes in children. Primary outcome was the first‐attempt success rate tracheal intubation, secondary were number attempts and complications. hypothesized that would be associated with lower rate. Methods In micrognathic patients enrolled Pediatric Difficult Intubation Registry (08/2012–03/2019) we retrospectively compared demographic clinical characteristics between...
The tachykinin hemokinin-1 (HK-1) is involved in immune cell development and inflammation, but little known about its function pain. It acts through the NK1 receptor, several effects are mediated by a yet unidentified target. Therefore, we investigated role mechanism of action HK-1 arthritis models distinct mechanisms with special emphasis on Arthritis was induced i.p. K/BxN serum (passive transfer inflammatory cytokines, autoantibodies), intra-articular mast tryptase or Complete Freund’s...
Background: Somatostatin released from the capsaicin-sensitive sensory nerves mediates analgesic and anti-inflammatory effects via its receptor subtype 4 (SST ) without influencing endocrine functions. Therefore, SST is considered to be a novel target for drug development in pain, especially chronic neuropathy which great unmet medical need. Purpose Experimental Approach: Here, we examined silico binding, -linked G protein activation β-arrestin on stable expressing cells of our...
COVID-19 forced healthcare systems to make unprecedented changes in clinical care processes. The authors hypothesized that the pandemic adversely impacted timely access care, perioperative processes, and outcomes for pediatric patients undergoing primary appendectomy.
Summary Background Knowledge of the normal nares‐to‐carina ( NC ) distance might prevent accidental bronchial intubation and be helpful when designing preformed endotracheal tubes ETT ). Objective The aim was to measure examine whether a height/length‐based ‘modified Morgan formula’ would give useful guidance for nasotracheal depth positioning. Methods Two groups were studied. A younger group consisted nasally intubated postoperative patients. In these, obtained as sum length from tip...
Summary Introduction Randomized trials are important for generating high‐quality evidence, but perceived as difficult to perform in the pediatric population. Thus far there has been poor characterization of barriers conducting involving children, and variation these between countries remains undescribed. The General Anesthesia compared Spinal anesthesia ( GAS ) trial, conducted seven 2007 2013, provides an opportunity explore issues. Methods We undertook a descriptive analysis evaluate...