A5101424397- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Organ Transplantation Techniques and Outcomes
- Gallbladder and Bile Duct Disorders
- Liver Disease and Transplantation
- Cancer Mechanisms and Therapy
- Cancer, Lipids, and Metabolism
- Drug Transport and Resistance Mechanisms
- Liver physiology and pathology
- Pediatric Hepatobiliary Diseases and Treatments
- Pancreatitis Pathology and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer Genomics and Diagnostics
- PI3K/AKT/mTOR signaling in cancer
- Renal cell carcinoma treatment
- Pulmonary Hypertension Research and Treatments
- Hepatitis C virus research
- Inflammatory Biomarkers in Disease Prognosis
- Nutrition and Health in Aging
- Anesthesia and Sedative Agents
- Lung Cancer Research Studies
- Anesthesia and Neurotoxicity Research
- Mast cells and histamine
Martin Luther University Halle-Wittenberg
2013-2025
University Hospital in Halle
2024
Heidelberg University
2014-2023
MRC Unit for Lifelong Health and Ageing
2018-2023
University College London
2018-2023
University Hospital Heidelberg
2013-2023
Medical Research Council
2022
University of London
2022
Hopp Children's Cancer Center Heidelberg
2018-2021
Heinrich Heine University Düsseldorf
2021
Abstract Background Hepatoblastoma is a rare disease that nevertheless accounts for the majority of liver malignancies in children. Due to limited epidemiological data, therapy hepatoblastoma tends be individualized. This study aimed evaluate incidence trends and develop nomogram predict survival children with newly diagnosed on population‐based level. Methods Individuals up 18 years age recorded registries Surveillance, Epidemiology, End Results (SEER) database between 2004 2015 were...
Background— Muscle LIM protein (MLP) is an essential nuclear regulator of myogenic differentiation. Additionally, it may act as integrator assembly the actin-based cytoskeleton. MLP-knockout mice develop a marked cardiac hypertrophy reaction and dilated cardiomyopathy (DCM). MLP therefore candidate gene for heritable forms hypertrophic (HCM) DCM in humans. Methods Results— We analyzed 1100 unrelated individuals (400 patients with DCM, 200 HCM, 500 controls) mutations human CRP3 that encodes...
Cerebral ischemia has been proposed as a contributing mechanism to secondary neuronal injury after intracerebral hemorrhage (ICH). The search for surrogate parameters that allow treatment stratification spontaneous ICH continues. We sought assess the presence and prognostic effect of perihemorrhagic ischemic changes hypoperfusion in prospective stroke MRI study.We performed 32 patients with hyperacute (mean, 16.9+/-17.2 mL) within 6 hours symptom onset 3.1+/-1.3 hours). Clinical data at...
Adjuvant chemotherapy prolongs survival in patients with pancreatic cancer, but its benefit is limited. Long-term times of up to 44 months after adjuvant chemoradioimmunotherapy phase II trials motivated the present study.Between 2004 and 2007, 132 R0/R1 resected received either fluorouracil (FU), cisplatin, interferon alfa-2b (IFN α-2b) plus radiotherapy followed by two cycles FU (arm A, n=64) or six monotherapy B, n=68). One hundred ten n=53; arm n=57) at least one dose study medication,...
Abstract Melatonin has been shown to exert anticancer activity on hepatocellular carcinoma ( HCC ) through its antiproliferative and pro‐apoptotic effect in both experimental clinical studies, sorafenib is the only approved drug for systemic treatment of . Thus, this study was designed investigate combined melatonin proliferation, apoptosis, possible mechanism human Here, we found that resulted a dose‐dependent growth inhibition HuH‐7 cells after 48 hours treatment, combination them enhanced...
There is an unmet public health need to understand better the relationship between baseline cognitive function, occurrence and severity of delirium, subsequent decline. Our aim was quantify cognition delirium follow-up impairment.
Free radicals are involved in pathophysiology of ischemia/reperfusion injury (IRI). Melatonin is a potent scavenger reactive oxygen and nitrogen species. Thus, this study was designed to elucidate its effects model rat kidney transplantation. Twenty Lewis rats were randomly divided into 2 groups (n = 10 animals each). (50 mg/kg BW) dissolved 5 mL milk given one group via gavage hr before left donor nephrectomy. Controls the same volume only. Kidney grafts then transplanted bilaterally...
Disease progression of hepatocellular cancer (HCC) in patients eligible for liver transplantation (LTx) occurs up to 50% patients, resulting withdrawal from the LTx waiting list. Transarterial chemoembolization (TACE) is used as bridging therapy with highly variable response rates. The oral multikinase inhibitor sorafenib significantly increases overall survival and time-to-progression advanced cancer. HeiLivCa study a double-blinded, controlled, prospective, randomized multi-centre phase...
Liver Transplantation (LT) is treatment of choice for patients with hepatocellular carcinoma (HCC) within MILAN Criteria. Tumour progression and subsequent dropout from waiting list have significant impact on the survival. Transarterial chemoembolization (TACE) controls tumour growth in treated HCC nodule, however, risk development untreated liver increased by simultaneous release neo-angiogenic factors. Due to its anti-angiogenic effects, Sorafenib delays HCC. Aim this study was determine...
In rodents, the cholinomimetic convulsant pilocarpine is widely used to induce status epilepticus (SE), followed by hippocampal damage and spontaneous recurrent seizures, resembling temporal lobe epilepsy. This model has initially been described in rats, but increasingly mice, including C57BL/6 (B6) inbred strain. present study, we compared effects of three B6 substrains (B6JOla, B6NHsd B6NCrl) that were previously reported differ several behavioral genetic aspects. B6JOla B6NHsd, only a...
Distal myopathies are a heterogeneous group of disorders characterized by progressive weakness and muscular atrophy, beginning in distal limb muscles affecting proximal at later stage. We studied large German kindred with 10 affected members. Weakness atrophy the anterior tibial started between ages 8 16 years, followed intrinsic hand muscles. Progression was slow, patients retained ability to walk until seventh decade. Serum creatinine kinase levels were increased range 150–1400 U/l. Muscle...
Upon stimulation of cells with transforming growth factor β (TGF-β), Smad proteins form trimeric complexes and activate a broad spectrum target genes. It remains unresolved which the possible are formed in cellular contexts how these contribute to gene expression. By combining quantitative mass spectrometry computational selection strategy, we predict provide experimental evidence for three most relevant mouse hepatoma cell line Hepa1-6. Utilizing dynamic pathway modeling, specify...
Article21 July 2020Open Access Transparent process Disentangling molecular mechanisms regulating sensitization of interferon alpha signal transduction Frédérique Kok orcid.org/0000-0002-7855-1422 Division Systems Biology Signal Transduction, German Cancer Research Center (DKFZ), Heidelberg, Germany Faculty Biosciences, Heidelberg University, Search for more papers by this author Marcus Rosenblatt Institute Physics, University Freiburg, FDM - Freiburg Data Analysis and Modeling, Melissa...
Objective A detailed understanding of the molecular alterations in different forms cholangiocarcinogenesis is crucial for a better cholangiocarcinoma (CCA) and may pave way to early diagnosis treatment options. Design We analysed clinicopathologically well-characterised patient cohort (n=54) with high-grade intraductal papillary (IPNB) or tubulopapillary (ITPN) neoplastic precursor lesions biliary tract correlated results an independent non-IPNB/ITPN associated CCA (n=294). The triplet...
Comparability of morbidity and mortality rates after total pancreatectomy (TP) reported by different surgical centers is limited. Procedure-specific differences, such as the extent resection, including additional vascular or multivisceral resections, are rarely acknowledged when postoperative outcomes reported.To evaluate TP categorize types based on extent, complexity, technical aspects each procedure.This single-center study included a retrospective cohort 1451 patients who had undergone...
Clinically significant posthepatectomy liver failure (PHLF B+C) remains the main cause of mortality after major hepatic resection. This study aimed to establish an APRI+ALBI, aspartate aminotransferase platelet ratio (APRI) combined with albumin-bilirubin grade (ALBI), based multivariable model (MVM) predict PHLF and compare its performance indocyanine green clearance (ICG-R15 or ICG-PDR) albumin-ICG evaluation (ALICE).
Abstract After surgical intervention with curative intention in specialised centres the five-year survival of patients carcinoma exocrine pancreas is only 15%. The ESPAC-1 trial showed an increased 21% achieved adjuvant chemotherapy. Investigators from Virginia Mason Clinic have reported a 5-year rate 55% phase II evaluating chemotherapy, immunotherapy and external-beam radiation. Design CapRI study open, controlled, prospective, randomised multi-centre III trial. Patients arm A will be...
Reactive oxygen species (ROS) are involved in pathophysiology of ischemia/reperfusion injury. Melatonin is a potent scavenger ROS. Thus, this study was designed to elucidate its effects combined hepatic warm ischemia and resection model. The right lateral caudate lobes (32% liver volume) Sprague-Dawley rats underwent for 30 min followed by reperfusion subsequent the nonischemic tissue. Some were gavaged with 50 mg/kg melatonin 2 hr before onset experiments. Controls received same volume...
Our previous findings demonstrated an increase in pulmonary mast cells (MCs) idiopathic arterial hypertension (IPAH). Also, literature suggests a potential role for MCs chronic obstructive disease (COPD). However, comprehensive investigation of lungs from patients is still needed. We systematically investigated the presence/expression MCs/MC chymase IPAH and COPD by (immuno)histochemistry subsequent quantification. found that total perivascular chymase‐positive were significantly higher than...