A5100696301- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Circular RNAs in diseases
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Breast Cancer Treatment Studies
- Cancer Risks and Factors
- Peroxisome Proliferator-Activated Receptors
- Ultrasound and Hyperthermia Applications
- Drug Transport and Resistance Mechanisms
- Curcumin's Biomedical Applications
- Pulmonary Hypertension Research and Treatments
- Cancer, Lipids, and Metabolism
- Photoacoustic and Ultrasonic Imaging
- Endoplasmic Reticulum Stress and Disease
- Cervical Cancer and HPV Research
- Mycobacterium research and diagnosis
- Elasticity and Material Modeling
- Pharmacological Effects of Natural Compounds
- Angiogenesis and VEGF in Cancer
- Nanoplatforms for cancer theranostics
- Cellular Mechanics and Interactions
- Protein Degradation and Inhibitors
Wuhan Polytechnic University
2020-2023
Zhejiang University
2011-2021
Tianjin Medical University
2014-2021
Dalian Medical University
2020
First Affiliated Hospital of Dalian Medical University
2020
Tangshan Gongren Hospital
2013-2019
Affiliated Hospital of Nantong University
2017-2018
Nantong University
2017-2018
Harbin Medical University
2016
Hebei Medical University
2015
In 1989, the National Surgical Adjuvant Breast and Bowel Project initiated B-22 trial to determine whether intensifying or increasing total dose of cyclophosphamide in a doxorubicin-cyclophosphamide combination would benefit women with primary breast cancer positive axillary nodes. B-25 was further yield more favorable results.Patients (n = 2,548) were randomly assigned three groups. The intensity doxorubicin similar all Group 1 received four courses, ie, double given standard therapy group;...
Abstract Ovarian cancer ranks as the second most common tumor of female reproductive system, with a large burden on global public health. Therefore, identification novel molecular targets and diagnostics is an urgent need for many women affected by this disease. To end, human transcription factor SOX2 involved in wide range pathophysiological roles, such maintenance stem cell characteristics carcinogenesis. date, studies, has been shown to promote development cancer, although its inhibitory...
<title>Abstract</title> <italic><bold>Background: </bold></italic>This study aims to investigate the relationship between long-term survival in esophageal squamous cell carcinoma (ESCC) patients and various clinical factors, including age, sex, examined lymph nodes (ELN), tumor size, T stage, N grade, surgical procedure. These findings aim provide surgeons with precise information avoid overtreatment. <italic><bold>Materials Methods:</bold></italic> Random forest Cox proportional hazard...
Background: Holly ( Ilex latifolia Thunb.) polyphenols extracts (HPE) contain high amounts of polyphenols, including phenolic acids, triterpenoids, tannic and so on, which have strong antioxidant function. This experiment was aimed to explore the protective effect mechanism HPE against hepatic injury induced by diquat. Methods: Thirty-two weaned piglets were allotted a 2 × factorial design with diet type (basal vs. diet) diquat challenge (saline diquat). On 21st day, injected or saline. One...
Sonodynamic therapy (SDT) has been recognized as a spatial–temporal and noninvasive modality for the treatment of deep-seated tumors. However, current sonosensitizers suffer from low sonodynamic efficacy. Herein, we reported design nuclear factor kappa B (NF-κB) targeting (TR1, TR2, TR3) by integrating resveratrol motif into conjugated electron donor–acceptor (triphenylamine benzothiazole) skeleton. Among these sonosensitizers, TR2 with two units in one molecule was most potent inhibiting...
The beneficial effects of glycine were tested in piglets with diquat-induced hepatic injury.Thirty-two assigned by a 2×2 factorial experimental design including supplementation and diquat challenge. After 3 weeks feeding basic diet or 1% supplemented diet, challenged saline. 1 week later, the slaughtered samples collected.Our results indicated that alleviated induced morphological injury, decreased activities plasma alanine aminotransferase, aspartate aminotransferase glutamyl transpeptidase...
LncRNA SNHG4 has been reported to be an oncogenic lncRNA in osteosarcoma. Our preliminary analysis of the cancer genome atlas dataset revealed upregulation glioblastoma (GBM). In this study, we confirmed GBM tissues collected from patients. addition, lower survival rate patients was observed with high expression level. can directly interact miR-138, while no altered after miR-138 overexpression. Interestingly, overexpression led c-Met, a target miR-138. Cell counting kit-8 assay showed that...
Abstract Objective This study investigated the feasibility of predicting expression levels Ki-67 in breast cancer using ultrasonographic findings and clinical features. Methods Fifty-eight patients, with 82 lesions confirmed by surgical pathology, were selected retrospectively for this study. Conventional ultrasound examination elastography performed before surgery. Clinical features (age, estrogen receptor (ER), progesterone receptor, human epidermal growth factor receptor-2 levels),...
We supposed that it will be a promising strategy to "prevent" multidrug resistance (MDR) instead of "reversing" it. This study was designed investigate the potency curcumin prevent acquired drug induced by adriamycin (ADM) in native K562 cells.K562 cells were pretreated with or 0.5% DMSO for 24 h and then co-incubated ADM. P-glycoprotein (P-gp) mdr1 mRNA levels analyzed separately flow cytometry quantitative real-time RT-PCR. The intracellular Rh-123 accumulation also detected cytometer....
The biological function of the intronic microRNA-28 (miR-28) may be associated with roles its host gene, LIM domain lipoma‑preferred partner (LPP). LPP has been reported to promote smooth muscle cell migration in arterial injury and atherosclerosis. However, mechanism miR‑28 atherosclerosis remains unclear. In current study, aim was validate inhibitory effect miR‑28‑5p on extracellular signal‑regulated kinase 2 (ERK2), investigate role association cardiovascular disease. Western blotting...
Uterine leiomyoma (UL) is the most common type of benign tumor in women's reproductive system. A number genes has been found to play an important role initiation and progression UL, including miRNAs. In this study, our results exhibited that miR-93, a member mir-106b-25 cluster, significantly reduced cell viability, promoted cycle arrest, caused apoptosis, inhibited migration UL cells (p < .01). Moreover, have provided experimental evidence miR-93 regulated biological functions by targeting CCND1.
We investigated the baseline characterization of cardiovascular disease (CVD)-derived circulating miR-221-3p/222-3p in isolated low HDL-C phenotype (ILHP) to enhance our understanding on their molecular pathological pattern prior onset.We screened 174 asymptomatic subjects with (n = 88) and normal lipid 86), detected levels CVD-derived using TaqMan miRNA Real-time PCR detection system.We found inverted decreased miR-221-3p (0.415 [0.249, 1.004] vs 0.658 [0.347, 1.534], p 0.002) versus...
Apoptin, derived from the chicken anemia virus, has been found to exert tumor-preferential apoptotic activity. It is a potential anticancer agent with direct clinical applications. However, if this viral protein were be used as new drug, it might also induce strong immune response, causing toxic side effects. In previous study, our group showed that TAT-apoptin downregulates stress expression of heat shock 70 by competing factor 1 in binding element (HSE) promoter region 70, thus inducing...
Objectives Pancreatic ductal adenocarcinoma (PDAC), as the most frequent pancreatic tumor, featuring high death rate. The current study intends to explore biological role of PSMA3 antisense RNA 1 (PSMA3-AS1) and its mechanism underlying PDAC progression. Methods Expression analyses were conducted using quantitative reverse transcription–polymerase chain reaction. Proliferative, apoptotic, migratory, invasive capacities determined by functional assays, encompassing 5-ethynyl-2′-deoxyuridine,...
Background: Nicotinamide N-methyltransferase (NNMT), a cytosolic enzyme that catalyzes the N-methylation of nicotinamide, has been shown to be critical for promoting cancer progression, but little is known its role in gastric and colorectal cancers.Methods: We explored NNMT predicting prognosis immune infiltration cancers. Data was obtained from RNAseq Atlas, Oncomine, tumor Immune Estimation Resource (TIMER) databases, Kaplan-Meier plotter, PrognoScan database Gene Expression Profiling...
e13526 Background: Oridonin, a diterpenoid purified from the Chinese herb Rabdosia rubescens, has anti-inflammatory and potentially anti-tumor property. We aimed to study antitumor effect of oridonin on panel human non-small cell lung cancer (NSCLC) lines. Methods: Human NSCLC lines with wild-type EGFR gene RAS mutation were treated escalating dose concentration (from 2.5 50 µM). Antitumor was measured by 72-hr growth inhibition 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide...