A5003744273- Nerve injury and regeneration
- Electrospun Nanofibers in Biomedical Applications
- Dendrimers and Hyperbranched Polymers
- RNA Interference and Gene Delivery
- Mesenchymal stem cell research
- Cancer Genomics and Diagnostics
- Spinal Cord Injury Research
- Curcumin's Biomedical Applications
- Graphene and Nanomaterials Applications
- Microfluidic and Bio-sensing Technologies
- Advanced biosensing and bioanalysis techniques
- biodegradable polymer synthesis and properties
- Extracellular vesicles in disease
- Cancer Cells and Metastasis
- Conducting polymers and applications
- Nerve Injury and Rehabilitation
- Tissue Engineering and Regenerative Medicine
International Iberian Nanotechnology Laboratory
2019
University of Minho
2012-2016
The use of human mesenchymal stem cells (hMSCs) has emerged as a possible therapeutic strategy for CNS-related conditions. Research in the last decade strongly suggests that MSC-mediated benefits are closely related with their secretome. Studies published recent years have shown secretome hMSCs isolated from different tissue sources may present significant variation. With this mind, work performed comparative proteomic-based analysis through mass spectrometry on derived bone marrow (BMSCs),...
Biosynthetic nerve grafts are desired as alternative to autologous in peripheral reconstruction.Artificial conduits still have their limitations and not widely accepted the clinical setting.Here we report an analysis of fine-tuned chitosan tubes used reconstruct 10 mm defects adult rat.The displayed low, medium high degrees acetylation (DAI: w2%, DA: w5%, DAIII: w20%) therefore different degradability microenvironments for regenerating tissue.Short long term investigations were performed...
Liquid biopsy offers unique opportunities for low invasive diagnosis, real-time patient monitoring and treatment selection. The phenotypic molecular profile of circulating tumor cells (CTCs) can provide key information about the biology cells, contributing to personalized therapy. CTC isolation is still challenging, mainly due their heterogeneity rarity. To overcome this limitation, a microfluidic chip label-free CTCs from peripheral blood was developed. This device, CROSS chip, captures...
Abstract The control and manipulation of cells that trigger secondary mechanisms following spinal cord injury (SCI) is one the first opportunities to minimize its highly detrimental outcomes. Herein, ability surface‐engineered carboxymethylchitosan/polyamidoamine (CMCht/PAMAM) dendrimer nanoparticles intracellularly deliver methylprednisolone (MP) glial cells, allowing a controlled sustained release this corticosteroid in site, investigated. negatively charged MP‐loaded CMCht/PAMAM with...
Natural biomaterials have attracted an increasing interest in the field of tissue-engineered nerve grafts, representing a possible alternative to autologous transplantation. With prospect developing novel entubulation strategy for transected nerves with cell-seeded chitosan films, we examined biocompatibility such films vitro. Different types rat Schwann cells (SCs)--immortalized, neonatal, and adult-of substrate. Both cell were viable on biomaterial showed different metabolic activities...
Spinal cord injury (SCI) leads to devastating neurological deficits. Several tissue engineering (TE)‐based approaches have been investigated for repairing this condition. Poly (3‐hydroxybutyrate‐ co ‐3‐hydroxyvalerate) (PHB‐HV) is found be particularly attractive TE applications due its properties, such as biodegradability, biocompatibility, thermoplasticity and piezoelectricity. Hence, report addresses the development characterization of PHB‐HV‐based 3D scaffolds, produced by freeze‐drying,...