A5070382146- Nerve injury and regeneration
- Nerve Injury and Rehabilitation
- Electrospun Nanofibers in Biomedical Applications
- Neurogenesis and neuroplasticity mechanisms
- Tissue Engineering and Regenerative Medicine
- Neuroscience and Neural Engineering
- Silk-based biomaterials and applications
- Pluripotent Stem Cells Research
- Wound Healing and Treatments
- Amyotrophic Lateral Sclerosis Research
- Mesenchymal stem cell research
- Peripheral Nerve Disorders
- Axon Guidance and Neuronal Signaling
- Neuroscience and Neuropharmacology Research
- Fibroblast Growth Factor Research
- Anesthesia and Neurotoxicity Research
- Tendon Structure and Treatment
- Pain Mechanisms and Treatments
- Graphene and Nanomaterials Applications
- Reconstructive Surgery and Microvascular Techniques
- Neurogenetic and Muscular Disorders Research
- Botulinum Toxin and Related Neurological Disorders
- Cancer Treatment and Pharmacology
- RNA Interference and Gene Delivery
- Apelin-related biomedical research
Medizinische Hochschule Hannover
2016-2025
Neuroscience Institute
2025
University of Padua
2025
Center for Systems Biology Dresden
2020
University of Würzburg
2006
Hannover Re (Germany)
2001
Metal-organic frameworks (MOFs) are promising platforms for the synthesis of nanoparticles diverse medical applications. Their fundamental design principles allow significant control framework architecture and pore chemistry, enabling directed functionalization nanomedical However, before applying novel nanomaterials to patients, it is imperative understand their potential health risks. In this study, nanosafety different MOF analyzed comprehensively The authors first evaluate effects MOFs...
Biosynthetic nerve grafts are developed in order to complement or replace autologous for peripheral reconstruction. Artificial guides currently approved clinical use not widely applied reconstructive surgery as they still have limitations especially when it comes critical distance repair. Here we report a comprehensive analysis of fine-tuned chitosan (CNGs) enhanced by introduction longitudinal film reconstruct length 15 mm sciatic defects adult healthy Wistar diabetic Goto-Kakizaki rats....
To understand the mechanisms of remyelination and reasons for regeneration failure is one major challenges in multiple sclerosis research. This requires a good knowledge reliable analysis experimental models. work was undertaken to characterize pattern myelin protein expression during remyelination. Acute demyelination corpus callosum induced by feeding 0.3% cuprizone 6 weeks, followed 10‐week period. We used combination Luxol fast blue (LFB) staining, electron microscopy (EM)...
Biosynthetic nerve grafts are desired as alternative to autologous in peripheral reconstruction.Artificial conduits still have their limitations and not widely accepted the clinical setting.Here we report an analysis of fine-tuned chitosan tubes used reconstruct 10 mm defects adult rat.The displayed low, medium high degrees acetylation (DAI: w2%, DA: w5%, DAIII: w20%) therefore different degradability microenvironments for regenerating tissue.Short long term investigations were performed...
Among a panel of histone deacetylase (HDAC) inhibitors investigated, suberoylanilide hydroxamic acid (SAHA) evolved as potent and non-toxic candidate drug for the treatment spinal muscular atrophy (SMA), an alpha-motoneurone disorder caused by insufficient survival motor neuron (SMN) protein levels. SAHA increased SMN levels at low micromolar concentrations in several neuroectodermal tissues, including rat hippocampal brain slices motoneurone-rich cell fractions, its therapeutic capacity was...
Short-term low-frequency electrical stimulation (ESTIM) of proximal peripheral nerve stumps prior to end-to-end coaptation or tubular bridging small distances has been reported increase preferential motor reinnervation and functional recovery in animal models human patients undergoing carpal tunnel release surgery. We investigated the effects ESTIM on regeneration across rat sciatic gaps, which exceed that allow spontaneous regeneration. Three different reconstruction approaches were...
Critical length nerve defects in the rat sciatic model were reconstructed with chitosan guides filled Schwann cells (SCs) containing hydrogel. The transplanted SCs naive or had been genetically modified to overexpress neurotrophic factors, thus providing a cellular factor delivery system. Prior assessment vivo, vitro studies evaluating properties of engineered overexpressing glial cell line-derived (GDNF) fibroblast growth 2 (FGF-2 18kDa ) demonstrated their neurite outgrowth inductive...
Polyvinylidene fluoride (PVDF) and its copolymer with trifluoroethylene (P(VDF-TrFE)) are considered as promising biomaterials for supporting nerve regeneration because of their proven biocompatibility piezoelectric properties that could stimulate cell ingrowth due to electrical activity upon mechanical deformation. For the first time, this study reports on comparative analysis PVDF P(VDF-TrFE) electrospun scaffolds in terms structural well vitro performance. A dynamic impact test machine...
Local delivery of neurotrophic factors is a pillar neural repair strategies in the peripheral nervous system. The main disadvantage free growth their short half-life few minutes. In order to prolong activity, we have conjugated iron oxide nanoparticles three factors: nerve factor ( β NGF), glial cell-derived (GDNF), and basic fibroblast (FGF-2). Comparative stability studies versus revealed that were significantly more stable tissue cultures medium at 37°C. biological effects examined on...
Abstract The peripheral nervous system has an intrinsic capability to regenerate, crucially related the ability of Schwann cells (SC) create a permissive environment, for example, through production regeneration‐promoting neurotrophic factors. Survival, proliferation, migration and differentiation SC into myelinating phenotype during development after injury is regulated by different Neuregulin1 (NRG1) isoforms. This study investigates expression NRG1 isoforms their ErbB receptors in distal...
Gut microbiota is responsible for essential functions in human health. Several communication axes between gut and other organs via neural, endocrine, immune pathways have been described, perturbation of composition has implicated the onset progression an emerging number diseases. Here, we analyzed peripheral nerves, dorsal root ganglia (DRG), skeletal muscles neonatal young adult mice with following status: a) germ-free (GF), b) gnotobiotic, selectively colonized 12 specific bacterial...
Natural biomaterials have attracted an increasing interest in the field of tissue-engineered nerve grafts, representing a possible alternative to autologous transplantation. With prospect developing novel entubulation strategy for transected nerves with cell-seeded chitosan films, we examined biocompatibility such films vitro. Different types rat Schwann cells (SCs)--immortalized, neonatal, and adult-of substrate. Both cell were viable on biomaterial showed different metabolic activities...
Delayed reconstruction of transection or laceration injuries peripheral nerves is inflicted by a reduced regeneration capacity. Diabetic conditions, more frequently encountered in clinical practice, are known to further impair nerves. Chitosan nerve guides (CNGs) have recently been introduced as new generation medical devices for immediate reconstruction. Here, CNGs were used 45 days delayed critical length 15 mm rat sciatic defects either healthy Wistar rats diabetic Goto-Kakizaki rats; the...
Abstract We present here a fast protocol that could be used to obtain highly purified cultures of maximal proliferating adult rat Schwann cells. These cells can transfected in nonbiological way using the physical transfection method electroporation. are decisive recovery peripheral nerves after injury. In clinical context, use enriched is necessary for autologous cell transplantation within nerve transplants repair. Different parameters such as tissue preparation, culture conditions, and...