A5100650146- MicroRNA in disease regulation
- Hepatitis B Virus Studies
- Cancer-related Molecular Pathways
- Cervical Cancer and HPV Research
- Circular RNAs in diseases
- Liver Disease Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Prostate Cancer Treatment and Research
- Pancreatic and Hepatic Oncology Research
- Cancer Mechanisms and Therapy
- Endoplasmic Reticulum Stress and Disease
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Medical Research and Treatments
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Advanced Glycation End Products research
- Cancer and Skin Lesions
- Lipid metabolism and disorders
- Flavonoids in Medical Research
- Economic and Financial Impacts of Cancer
- Nanoparticle-Based Drug Delivery
- Hepatitis C virus research
- Infectious Aortic and Vascular Conditions
Second Affiliated Hospital of Nanchang University
2020-2025
Nanchang University
2020-2025
Quzhou City People's Hospital
2011-2022
Wenzhou Medical University
2022
Wuhan University
2021
Renmin Hospital of Wuhan University
2021
Washington University in St. Louis
2019
Zhejiang University
2017
China University of Geosciences (Beijing)
2014
China Medical University
2007
Chrysin is a natural flavone that has various biological activities, including antitumor effects. However, the effect of chrysin on bladder cancer cells remains elusive. The present study investigated effects and its underlying mechanisms. results demonstrated induced apoptosis via intrinsic pathway, as evidenced by activation caspase‑9 caspase‑3, however not caspase‑8. In addition, reduced expression anti‑apoptotic B cell lymphoma (Bcl) proteins Bcl‑2, Mcl‑1, Bcl‑xl, promoted protein...
Nearly 30% of clear cell renal carcinoma (ccRCC) patients present with metastasis at the time diagnosis, and prognosis for these is poor. Therefore, novel potential prognostic biomarkers therapeutic targets ccRCC could be helpful. Emerging evidence indicates that lncRNAs play important roles in cancer tumorigenesis used as or targets. PANDAR (promoter CDKN1A antisense DNA damage activated RNA) a relatively lncRNA plays an role development multiple cancers. However, clinical significance...
This study aimed to investigate the effects of multiwalled carbon nanotubes (MWNTs) co-delivering sorafenib (Sor) and epidermal growth factor receptor (EGFR) siRNA (MWNT/Sor/siRNA) on tumor in liver cancer (LC).
Artificial vascular graft infection (AVGI) is a rare but severe complication in surgery, often associated with high morbidity and mortality. This case report highlights unique instance of AVGI caused by rectal fistula, emphasizing the diagnostic challenges management strategies such scenario. A 60-year-old female presented low-grade fever purulent discharge from an abdominal incision 1 year after antibiotic therapy had failed to resolve infection. She history aortofemoral dacron bypass 6...
Changes in N-glycosylation of proteins are thought to play a key role cancer. This study aims investigate the changes serum N-glycan profiles patients with hepatitis B virus (HBV)-related liver disease, and evaluate markers noninvasive diagnosis hepatocellular carcinoma (HCC).Serum samples were available for 21 HCC, 20 cirrhosis (LC), chronic (CHB), healthy subjects. Serum N-glycans released analyzed using DNA sequencer-assisted fluorophore-assisted carbohydrate electrophoresis (DSA-FACE)....
Background: Macrophage polarization is involved in the development of ulcerative colitis (UC). This study investigated mechanism by which high mobility group box-1 protein (HMGB1) regulates macrophage through metabolic reprogramming, thereby contributing to pathogenesis UC. Methods: Dextran sulfate sodium (DSS) was used induce mice. RAW264.7 cells were polarized M1 or M2 macrophages vitro stimulating with lipopolysaccharide (LPS)/interferon-γ (IFN-γ) Interleukin-4 (IL-4), respectively....
The study compared the diagnostic efficiency of serum oligosaccharide chain (G-test) and alpha-fetoprotein (AFP) for hepatitis B-related hepatocellular carcinoma (HCC). Serum samples from 100 patients (divided into five groups 20 each, namely hepatitis, liver cirrhosis, cancer, health, interference groups) who were admitted to Second Affiliated Hospital Nanchang University October 2019 January 2020 collected, levels G-test AFP determined. sensitivity specificity two indicators compared,...
Hepatocellular carcinoma (HCC) is one of the most common cancers around world with a poor prognosis. The main reason for prognosis early stage HCC inconspicuous so it difficult to detect and effective treatment strategies are lacking advanced HCC. In this context, novel molecular targets urgently needed diagnosis therapy study, we investigated expression level, biological function, relative mechanism Desmocollin-2(DSC2) in DSC2 levels were decreased significantly cell lines SMMC-7721(7721),...
The vibration controlled transient elastography (VCTE) technique was used to assess the effectiveness of a Biejia Decoction pill in combination with Entecavir treatment hepatitis B liver fibrosis/cirrhosis. We randomly selected 120 patients receive entecavir and 119 both Pill, which fibrosis/cirrhosis visited Second Affiliated Hospital Nanchang University between January 2019 February 2022. observation group got ETV (entecavir) pills, whereas control received only standard antiviral...
Previous epidemiological studies displayed that long non-coding RNA (LncRNA) polymorphisms are associated with an increased risk of coronary artery disease, while the results inconsistent. Therefore, we conducted a meta-analysis to more accurately determine association between LncRNA polymorphism and disease.PubMed, EmBase Web Science databases were searched, time build database was set until December 2020. The disease collected evaluated. Meta-analysis performed by STATA 14.0 software, odds...