A5101842789- Tuberculosis Research and Epidemiology
- RNA modifications and cancer
- Cell Adhesion Molecules Research
- Epigenetics and DNA Methylation
- Crystallization and Solubility Studies
- Mycobacterium research and diagnosis
- Pharmacological Effects of Natural Compounds
- RNA and protein synthesis mechanisms
- Cancer Mechanisms and Therapy
- Research on Leishmaniasis Studies
- Drug Solubulity and Delivery Systems
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Garlic and Onion Studies
- Polymer Surface Interaction Studies
- Antimicrobial Resistance in Staphylococcus
- Essential Oils and Antimicrobial Activity
- Genomics and Phylogenetic Studies
- Signaling Pathways in Disease
- Glioma Diagnosis and Treatment
- Herbal Medicine Research Studies
- Brake Systems and Friction Analysis
- Phytochemistry and Bioactivity Studies
- Medicinal Plants and Neuroprotection
- Polysaccharides and Plant Cell Walls
Central University of Haryana
2017-2025
Indian Institute of Technology Indore
2024
National Institute of Ayurveda
2023
Banaras Hindu University
2022
Institute of Microbial Technology
2010-2020
Council of Scientific and Industrial Research
2010-2020
Institute of Technology Management
2017
Sharda University
2016
Here we report an in-silico approach for identification, characterization and validation of deleterious non-synonymous SNPs (nsSNPs) in the interleukin-8 gene using three steps. In first step, sequence homology-based genetic analysis a set 50 coding associated with 41 rsIDs SIFT (Sorting Intolerant from Tolerant) PROVEAN (Protein Variation Effect Analyzer) identified 23 nsSNPs to be putatively damaging/deleterious at least one two tools used. Subsequently, structure-homology based PolyPhen-2...
A holistic biointegration of percutaneous bone-anchored metallic prostheses with both hard and soft tissues dictates their longevity in the human body. While titanium (Ti) has nearly solved osseointegration, tissue integration is a perennial problem. Unlike firm sealing biological structures (fingernails teeth), foreign body response skin to leads inflammation, epidermal downgrowth inferior peri-implant sealing. This review discusses various implant surface treatments/texturing coatings for...
Medicinal plants are a major source of numerous therapeutic agents, and the emergence pathogenic bacteria has rekindled interest in traditional medicine systems as an alternative approach to overcoming resistance. The dried plant material four medicinal plants, namely Terminalia arjuna (bark), bellirica (fruit), Aegle marmelos (leaves), Bacopa monnieri was powdered, aqueous extracts were prepared. antimicrobial activity evaluated against three clinically important strains: Pseudomonas...
Abstract The role of GTF2I (General Transcription Factor2I) alteration has already been reported in thymic cancer as a valuable biomarker. However, the association mutation with renal for prognosis immunotherapy is not yet examined. biologic and oncologic significance was examined at multiomics level such mutation, copy number alteration, structural variants. Cancer Genome Atlas (TCGA), Human Protein (HPA) were used to retrieve omics data. expression mRNA quite significant case caner....
The inability of sodium antimony gluconate (SAG)-unresponsive kala-azar patients to clear Leishmania donovani (LD) infection despite SAG therapy is partly due an ill-defined immune-dysfunction. Since dendritic cells (DCs) typically initiate anti-leishmanial immunity, a role for DCs in aberrant LD clearance was investigated. Accordingly, regulation SAG-induced activation murine following with isolates exhibiting two distinct phenotypes such as antimony-resistant (SbRLD) and antimony-sensitive...
Tuberculosis (TB) remains one of the greatest health concerns worldwide, which has hindered socio-economic development in certain parts world for many centuries. Although current TB therapy, "Directly Observed Treatment Short-course," is effective, it associated with unwanted side effects and risk generation drug-resistant organisms. The majority infected individuals suc-cessfully confine mycobacterial organisms remain asymptotic unless immune responses are perturbed. Thus, host immunity can...
Epigenetics denotes to study the heritable changes occurred in gene function without any DNA sequence. These epigenetic are known be governed by various factors viz. stress, infection, nutrients, drugs and toxicological agents etc. Recently, it has been identified that different microorganisms can cause host. In this review we intend address about host Mycobacterium tuberculosis (M.tb) infection then elaborate current state of research how Mtb. modulates epigenome. M.tb induced modifications...
Natural quinoline alkaloid camptothecin (CPT) is used for the treatment of colon, lung, breast and ovarian cancers still facing challenges due to low solubility in aqueous biological fluids. Its lactone form easily converts into a toxic carboxylic at slightly basic pH, typical blood tissue fluid has rapid clearance from systemic administration. We report new approach based on micro crystalline cellulose (MCC) nano (NCC) isolated natural sources such as Cymbopogan flexuosus stabilize regulate...
The level of CD40 expression on dendritic cells (DCs) plays a decisive role in disease protection during Leishmania donovani (LD) infection. However, current understanding the molecular regulation remains elusive. Using molecular, cellular and functional approaches, we identified for Runx1 Runx3 transcription factors DCs. In response to lipopolysaccharide (LPS), tumor necrosis factor alpha (TNFα) or antileishmanial drug sodium antimony gluconate (SAG), both translocated nucleus, bound...
Due to awareness and benefits of goat rearing in developing economies, goats' significance is increasing. Unfortunately, these ruminants are threatened via multiple bacterial pathogens such as enteropathogenic Escherichia coli (EPEC). In kids lambs, EPEC causes gastrointestinal disease leading substantial economic losses for farmers may also pose a threat public health the spread zoonotic diseases. Management infection primarily based on antibiotics, but need new therapeutic measures an...
Abstract Introduction We explored whether integrin αvβ8 inhibition potentiates immune checkpoint blockade (ICB) in syngeneic orthotopic models of breast cancer. Integrin mediates cell type specific and tissue localized activation TGFβ1/3 to regulate the system. For example, expressed on dendritic cells (DC) intestine has been shown be a key mediator tolerance, maintaining gut immunologic homeostasis. Methods Efficacy was evaluated combination with anti-PD-1 EMT6 PyMT cancer mouse models. A...