A5051816210- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Computational Drug Discovery Methods
- Cardiovascular Effects of Exercise
- Human Pose and Action Recognition
- Chemistry and Chemical Engineering
- Video Surveillance and Tracking Methods
- Advanced Vision and Imaging
- Sports Performance and Training
- Cardiovascular and exercise physiology
- Thermoregulation and physiological responses
- Blood properties and coagulation
- Cardiac Imaging and Diagnostics
- Exercise and Physiological Responses
- Sports injuries and prevention
- Adipose Tissue and Metabolism
- Fish Biology and Ecology Studies
- Protein Structure and Dynamics
- Environmental and Biological Research in Conflict Zones
- Muscle metabolism and nutrition
- Sleep and related disorders
- Remote Sensing and LiDAR Applications
- Click Chemistry and Applications
- Animal Diversity and Health Studies
- Gait Recognition and Analysis
Indiana University – Purdue University Indianapolis
2025
Indiana University School of Medicine
2025
Harvard University
1996-2024
Massachusetts General Hospital
2024
University College London Hospitals NHS Foundation Trust
2020-2023
University College London
2020-2023
Toi Ohomai Institute of Technology
2020-2022
University of Liverpool
2019-2021
Stellenbosch University
2019-2021
Alberta Health
2021
Wearable microfluidic system enables remote analysis of sweat rate and chloride loss for assessing personalized fluid needs.
The global burden of type 2 diabetes mellitus (T2DM), together with the presence cardiovascular risk in this population, is reaching pandemic levels. A prominent feature T2DM chronic and systemic inflammation, accompanying circulating dysregulated inflammatory biomarkers; which turn associated abnormal clot formation.Here, we investigate correlation between blood clotting, using thromboelastography (TEG), ultrastructure scanning electron microscopy (SEM) a cytokine profile, by examining...
Parkinson's disease (PD) is a well-known neurodegenerative with strong association established systemic inflammation. Recently, the role of gingipain protease group from Porphyromonas gingivalis was implicated in Alzheimer's and here we present evidence, using fluorescent antibody to detect R1 (RgpA), its presence PD population. To further elucidate action this gingipain, as well lipopolysaccharide (LPS) P. gingivalis, low concentrations recombinant RgpA LPS were added purified fibrinogen....
The purpose of this study was to expand our previously published sweat normative data/analysis (n = 506) establish sport-specific data for whole-body sweating rate (WBSR), [Na+], and Na+ loss (RSSL). Data from 1303 athletes were compiled observational testing (2000–2017) using a standardized absorbent patch technique determine local [Na+] normalized [Na+]. WBSR determined change in exercise body mass, corrected food/fluid intake urine/stool loss. RSSL the product WBSR. There significant...
Pittas Larks Swallows and Martins Pipits Wagtails Cuckoo-Shrikes, Wood Shrikes Minivets Bulbuls Ioras Leaf-birds Waxwings Dippers Accentors Niltava Flycatchers Fantail Paradise Flycatcher Monarch Babblers, Laughing Thrushes Shrike Babblers Sibias Long-tailed Tits Nuthatches Wallcreeper Tree Creepers Fire-capped Penduline Sunbirds Flower Peckers White-eyes Orioles Drongos Jays, Tree-pies Crows Starlings Mynas Sparrows, Rock Sparrows Snow Finches Weaver Birds Munias, Grass-finches Mannikins...
The aim of this study was to describe maximal fat oxidation (MFO) rates in an athletic population.In total, 1121 athletes (933 males and 188 females), from a variety sports competitive level, undertook graded exercise test on treadmill fasted state (≥5 h fasted). Rates were determined using indirect calorimetry.The average MFO 0.59 ± 0.18 g·min, ranging 0.17 1.27 g·min. Maximal occurred at intensity 49.3% 14.8% V˙O2max, 22.6% 88.8% V˙O2max. In absolute terms, male had significantly higher...
Objectives Pro-inflammatory cytokines have been noted to increase following exercise but their relationship exercise-induced cardiac dysfunction has not previously investigated. We sought evaluate whether was associated with increases in cytokines, particularly the pro-inflammatory IL-1β, IL-12p70 and TNFα, which most implicated pathology. Methods 40 well-trained endurance athletes underwent evaluation prior immediately one of four sporting events ranging from 3 11 hours duration. Cytokines...
Background: We aimed to compare closed-loop glucose control for people with type 1 diabetes undertaking high-intensity interval exercise (HIIE) versus moderate-intensity (MIE). Methods: Adults established on insulin pumps undertook HIIE and MIE stages in random order during automated delivery via a system (Medtronic). Frequent venous sampling glucose, lactate, ketones, insulin, catecholamines, cortisol, growth hormone, glucagon levels was performed. The primary outcome plasma <4.0 mmol/L ≥15...
We address the problem of generating novel molecules with desired interaction properties as a multi-objective optimization problem. Interaction binding models are learned from data using graph convolution networks (GCNs). Since experimentally obtained property scores recognised having potentially gross errors, we adopted robust loss for model. Combinations these terms, including drug likeness and synthetic accessibility, then optimized reinforcement learning based on policy approach. Some...
Abstract Gut dysbiosis contributes to the development of a dysfunctional gut barrier, facilitating translocation bacteria and inflammagens, is implicated in colorectal cancer (CRC) pathogenesis. Such ‘leaky gut’ conditions result systemic inflammation, which hallmark increased hypercoagulability. Fluorescence antibody confocal microscopy was used determine circulating levels lipopolysaccharide (LPS) control CRC populations. Here we showed that LPS are significantly elevated population. We...
SNAPPI-DB, a high performance database of Structures, iNterfaces and Alignments Protein–Protein Interactions, its associated Java Application Programming Interface (API) is described. SNAPPI-DB contains structural data, down to the level atom co-ordinates, for each structure in Protein Data Bank (PDB) together with data including SCOP, CATH, Pfam, SWISSPROT, InterPro, GO terms, Quaternary Structures (PQS) secondary information. Domain–domain interactions are stored multiple domain...
Left ventricular diastolic dysfunction is a well-described complication of systemic hypertension. However, less known regarding the effect chronic pressure overload on right (RV) function. We hypothesized that pulmonary hypertension (PHT) associated with abnormal RV early relaxation and this would be best shown by invasive measurement. Twenty-five patients undergoing heart catheterization for investigation breathlessness and/or suspected PHT were studied. In addition to standard...
The reasons for reduced exercise capacity in diabetes mellitus (DM) remains incompletely understood, although diastolic dysfunction and diabetic cardiomyopathy are often favored explanations. However, there is a paucity of literature detailing cardiac function reserve during incremental to evaluate its significance contribution. We sought determine associations between comprehensive measures maximal oxygen consumption ( $$\dot{V}O_{2}$$ peak), with the hypothesis that reduction would be...
Molecular similarity is an elusive but core “unsupervised” cheminformatics concept, yet different “fingerprint” encodings of molecular structures return very values, even when using the same metric. Each encoding may be value applied to other problems with objective or target functions, implying that a priori none are “better” than others, nor encoding-free metrics such as maximum common substructure (MCSS). We here introduce novel approach similarity, in form variational autoencoder (VAE)....
OBJECTIVE To determine whether pulmonary microvascular disease is detectable in subjects with diabetes and associated diminished exercise capacity using a novel echocardiographic marker quantifying the transit of agitated contrast bubbles (PTAC). RESEARCH DESIGN AND METHODS Sixty participants (40 20 control subjects) performed cardiopulmonary (maximal oxygen consumption [VO2peak]) semisupine bicycle echocardiography tests within 1-week period. Pulmonary was assessed PTAC (the number...
Anthracycline-based chemotherapy (AC) is a common treatment for patients with breast cancer and has been associated dramatic improvement in survivorship. Among early-stage cancer, cardiovascular diseases represent the most cause of mortality,
SUMMARY: Tim Roberts examines the evolving discourse surrounding American imperialism, tracing its historical rationalizations and critiques from late nineteenth century through present day. He highlights tension between exceptionalism, which often denies or justifies imperial actions, counterarguments that emphasize parallels with other empires. The analysis covers various scholarly interpretations, including Wisconsin School's focus on economic drivers, postcolonial perspectives cultural...
Abstract Psoriasis is a chronic, immune-mediated inflammatory skin disease, affecting approximately 2% of the general population, which can be accompanied by psoriatic arthritis (PsA). The condition has been associated with an increased cardiovascular burden. Hypercoagulability potential underlying mechanism that may contribute to risk major events in individuals. Whole blood samples were collected from 20 PsA patients and healthy concentrations molecules (C-reactive protein, serum amyloid...