A5008647312- Clinical Laboratory Practices and Quality Control
- Web and Library Services
- Acute Myeloid Leukemia Research
- Statistical Methods in Clinical Trials
- Wikis in Education and Collaboration
- Pharmacological Effects and Toxicity Studies
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Biotin and Related Studies
- Histone Deacetylase Inhibitors Research
- Chronic Kidney Disease and Diabetes
- Body Composition Measurement Techniques
- Forensic Toxicology and Drug Analysis
- Neuroblastoma Research and Treatments
- Methemoglobinemia and Tumor Lysis Syndrome
- Hemoglobinopathies and Related Disorders
- Bacterial Identification and Susceptibility Testing
- Redox biology and oxidative stress
- Epigenetics and DNA Methylation
- Microfluidic and Capillary Electrophoresis Applications
- Neonatal Health and Biochemistry
- Monoclonal and Polyclonal Antibodies Research
- Iron Metabolism and Disorders
- Gothic Literature and Media Analysis
- Acute Kidney Injury Research
University of Utah
2015-2025
ARUP Laboratories (United States)
2015-2025
AbbVie (United States)
2016-2024
ARUP Institute for Clinical and Experimental Pathology
2019-2023
Vanderbilt University Medical Center
2022
Vanderbilt Health
2022
Intermountain Medical Center
2019
Georgia Institute of Technology
2019
Yale University
2014-2019
Intermountain Healthcare
2016-2019
Recent data in invertebrates demonstrated that huntingtin (htt) is essential for fast axonal trafficking. Here, we provide direct and functional evidence htt involved trafficking mammals. Moreover, expression of full-length mutant (mhtt) impairs vesicular mitochondrial mammalian neurons vitro whole animals vivo. Particularly, mitochondria become progressively immobilized stop more frequently from transgenic animals. These defects occurred early development prior to the onset measurable...
MCL-1 is a prosurvival B-cell lymphoma 2 family protein that plays critical role in tumor maintenance and survival can act as resistance factor to multiple anticancer therapies. Herein, we describe the generation characterization of highly potent selective inhibitor ABBV-467 present findings from first-in-human trial included patients with relapsed/refractory myeloma (NCT04178902).Binding human was assessed cell lines. The ability induce growth inhibition investigated xenograft models acute...
Accurate reference intervals are essential for the interpretation of laboratory test results. Typically, they determined by central 95% range results from a predefined population. As these direct studies can face practical and ethical challenges, indirect methods using routine measurements offer an alternative approach.We provide step-by-step guidance on how to apply method in practice refineR, most recently published method, showcase application evaluating real-world data 12 prespecified...
Xanthomonas campestris pv. musacearum (Xcm) causes a disease on banana (Musa spp.) and enset (Ensete known as xanthomonas wilt (BXW). Recent studies have shown that Xcm is strain of X. vasicola (Aritua et al., 2008). However, the status pathovars within species remains unclear. Prior to its discovery in Uganda October 2001, had been limited Ethiopia (first reported 1968). Since then has spread Democratic Republic Congo Rwanda (observed May 2004 September 2005 respectively). BXW can cause...
Targeted delivery of a therapeutic agent to site pathology ameliorate disease while limiting exposure at undesired tissues is an aspirational treatment scenario. Targeting diseased kidneys for pharmacologic has had limited success. We designed approach target extracellular matrix protein, the fibronectin extra domain A isoform (FnEDA), which relatively restricted in distribution sites tissue injury. In mouse unilateral ureteral obstruction (UUO) model renal fibrosis, injury induced...
With the food system estimated to be responsible for approximately one-third of greenhouse gas emissions (1) there is an urgent need transition healthy and more environmentally sustainable diets. Plant-based ‘milks’ are associated with lower than dairy milks (2) many Australian consumers making substitution (3) . The 2013 Dietary Guidelines advise that plant-based fortified at least 100 mg calcium per ml (e.g., soy, rice or other cereal) can replace milk in diet (4) This study aimed assess...
Human peroxiredoxins serve dual roles as anti-oxidants and regulators of H2O2-mediated cell signaling. The functional versatility depends on progressive oxidation key cysteine residues. sulfinic or sulfonic forms peroxiredoxin lose their peroxidase activity, which allows cells to accumulate H2O2 for signaling pathogenesis in inflammation, cancer, other disorders. We report that arachidonic acid lipid hydroperoxide metabolites 5-, 12-, 15-lipoxygenase-1, cyclooxygenase-2 oxidize the...
Some amphetamine (AMP) and ecstacy (MDMA) urine immunoassay (IA) kits are prone to false-positive results due poor specificity of the antibody. We employed two techniques, high-resolution mass spectrometry (HRMS) an in silico structure search, identify compounds likely cause results. Hundred IA specimens for AMP and/or MDMA were analyzed by Agilent 6230 time-of-flight (TOF) spectrometer. Separately, SciFinder (Chemical Abstracts) was used as search generate a library that known cross-react...
Lysine-Specific Demethylase 1 (LSD1) over-expression correlates with poorly differentiated neuroblastoma and predicts poor outcome despite multimodal therapy. We have studied the efficacy of reversible specific LSD1 inhibition HCI-2509 in cell lines particularly effect on transcriptomic profile MYCN amplified NGP cells. Cell survival assays show that is cytotoxic to low micromole or lower doses. Transcriptional profiling cells treated shows a significant p53, cycle, hypoxia pathway gene...
Abstract Lung cancer has the highest rates of incidence (2.1 million cases/year) and mortality (1.8 deaths/year) among all cancers worldwide. Approximately 15% lung are small cell (SCLC). SCLC is typically diagnosed at late stages, with approximately 70% patients having extensive stage disease time diagnosis. Unfortunately, these have a dismal 5-year survival rate 3%. In contrast to non-small (NSCLC), there been little advancement in treatment SCLC, no biomarker directed therapies available...
Abstract Objectives This study determined the performance characteristics of a quantitative glucose-6-phosphate dehydrogenase (G6PD) assay with automated lysis and evaluated robustness operational workflow following implementation in hospital laboratory. Methods The G6PD activity was measured whole blood using an enzymatic test on Roche cobas c501 analyzer onboard configuration normalized to hemoglobin (Hb). method stability collected EDTA-containing tubes were evaluated, reference interval...
The solution structural and formyl substrate reactivity properties of a nitrogen/sulfur-ligated zinc hydroxide complex, [(bmnpaZn)2(mu-OH)2](ClO4)2 (1, bmnpa = N,N-bis-2-(methylthio)ethyl-N-((6-neopentylamino-2-pyridyl)methyl)amine), in acetonitrile methanol are reported. In CH3CN, 1 has binuclear cation [(bmnpaZn)2(mu-OH)2]2+ that is stabilized by secondary hydrogen bonding CH/pi interactions involving the chelate ligand. CH3OH, undergoes reaction with solvent to yield methoxide species, as...
Abstract: During pregnancy, there are several physiological changes during each trimester that can affect the absorption, distribution, metabolism, and elimination of drugs. Although is a potential need to understand pharmacokinetics pharmacodynamics drugs in pregnant patients, therapeutic drug monitoring not well established for various classes due ethical safety concerns regarding neonate. Potential risks from utero exposure fetus may impact growth development cause malformations or...
Identifying febrile patients requiring antibacterial treatment is challenging, particularly in low-resource settings. In South-East Asia, C-reactive protein (CRP) has been demonstrated to be highly sensitive and moderately specific detecting bacterial infections safely reduce unnecessary prescriptions primary care. As evidence scant sub-Saharan Africa, we assessed the sensitivity of CRP identifying serious Tanzania.Samples were obtained from inpatients outpatients a prospective illness study...
Abstract Two mercury( II ) complexes [(bmppa)Hg(ClO 4 )]ClO { 1 , bmppa = N,N ‐bis(2‐methylthio)ethyl‐ N ‐[(6‐pivaloylamido‐2‐pyridyl)methyl]amine} and [(beppa)Hg(ClO 2 beppa ‐bis(2‐ethylthio)ethyl‐ ‐[(6‐pivaloylamido‐2‐pyridyl)‐methyl]amine} of S (thioether)O(amide)‐donor chelate ligands have been prepared characterized by X‐ray crystallography and/or spectroscopic methods. In the solid state, Hg ion exhibits an overall coordination number six strong amide oxygen coordination. Comprehensive...
Blood collections from peripheral intravenous catheters offer several benefits to patients, including reduced needle punctures and patient discomfort, but they risk reducing the quality of blood specimens analyzed by laboratory. In an effort balance analytical test results with patient-centered care initiatives, a needle-less collection device called PIVO™ was evaluated at two institutions. The primary objective this study assess ability provide high-quality for laboratory testing compared...
Abstract 20-25% of acute myeloid leukemia (AML) patients harbor FLT3 internal tandem duplication (ITD) mutations, which confer poorer prognosis. FLT3-ITD is a constitutively activated kinase with differential signaling compared to wild type (WT) FLT3. Notably, activates STAT5, can regulate the prosurvival proteins BCL-XL and MCL-1. Venetoclax, potent, selective inhibitor protein BCL-2, demonstrated monotherapy activity in relapsed/refractory AML (ORR 19%); however, no was seen mutant cases....