A5078084081- Viral Infections and Vectors
- Vector-borne infectious diseases
- Mosquito-borne diseases and control
- Vector-Borne Animal Diseases
- Malaria Research and Control
- Streptococcal Infections and Treatments
- Zoonotic diseases and public health
- Brucella: diagnosis, epidemiology, treatment
- Viral Infections and Outbreaks Research
- Bacterial Identification and Susceptibility Testing
- Hepatitis B Virus Studies
- Antibiotic Use and Resistance
Centers for Disease Control and Prevention
2012-2025
National Center for Emerging and Zoonotic Infectious Diseases
2024
CDC Foundation
2016
Several spotted fever group rickettsiae (SFGR) previously believed to be nonpathogenic are speculated contribute infections commonly misdiagnosed as Rocky Mountain (RMSF) in the United States, but confirmation is difficult cases with mild or absent systemic symptoms. We report an afebrile rash illness occurring a patient 4 days after being bitten by Rickettsia montanensis-positive Dermacentor variabilis tick. The patient's serological profile was consistent confirmed SFGR infection.
Historically, malaria has been the predominant cause of acute febrile illness (AFI) in sub-Saharan Africa. However, during last two decades, incidence declined due to concerted public health control efforts, including widespread use rapid diagnostic tests leading increased recognition non-malarial AFI etiologies. Our understanding is limited lack laboratory capacity. We aimed determine etiology three distinct regions Uganda.
Tick-borne diseases cause substantial morbidity throughout the United States, and North Carolina has a high incidence of spotted fever rickettsioses ehrlichiosis, with sporadic cases Lyme disease. The occupational risk tick-borne infections among outdoor workers is high, particularly those working on publicly managed lands. This study identified incident examined seroconversion factors cohort workers. Workers from State Divisions Forestry, Parks Recreation, Wildlife (n = 159) were followed...
Acute Q fever diagnosis via paired serology is problematic because it requires follow-up for convalescent sample collection; as such, cannot provide a to inform treatment decision at the time of acute presentation. Real-time polymerase chain reaction (PCR) may be useful approach in endemic settings. Among febrile patients enrolled sentinel surveillance study two referral hospitals Moshi, Tanzania, from 2012 2014, we analyzed those with sera IgG Coxiella burnetii (C. burnetii) phase II...
During the Ebola virus outbreak of 2013–2016, Viral Special Pathogens Branch field laboratory in Sierra Leone tested approximately 26 000 specimens between August 2014 and October 2015. Analysis B2M endogenous control Ct values showed its utility monitoring specimen quality, comparing results with different types, interpretation results. For live patients, blood is most sensitive type oral swabs have little diagnostic utility. However, are highly for testing corpses.
Q fever and spotted group rickettsioses (SFGR) are common causes of severe febrile illness in northern Tanzania. Incidence estimates needed to characterize the disease burden. Using hybrid surveillance-coupling case-finding at two referral hospitals healthcare utilization data-we estimated incidences acute SFGR Moshi, Kilimanjaro, Tanzania, from 2007 2008 2012 2014. Cases were defined as a four-fold or greater increase antibody titers convalescent paired sera according indirect...
Abstract Background In northern Tanzania, Q fever, spotted fever group (SFG) rickettsioses, and typhus (TG) rickettsioses are common causes of febrile illness. We sought to describe the prevalence risk factors for these zoonoses in a pastoralist community. Methods Febrile patients ≥2 years old presenting Endulen Hospital Ngorongoro Conservation Area were enrolled from August 2016 through October 2017. Acute convalescent blood samples collected, questionnaire was administered. Sera tested by...
Identifying febrile patients requiring antibacterial treatment is challenging, particularly in low-resource settings. In South-East Asia, C-reactive protein (CRP) has been demonstrated to be highly sensitive and moderately specific detecting bacterial infections safely reduce unnecessary prescriptions primary care. As evidence scant sub-Saharan Africa, we assessed the sensitivity of CRP identifying serious Tanzania.Samples were obtained from inpatients outpatients a prospective illness study...
Abstract Background Knowledge gaps exist on risk factors for spotted fever group rickettsioses (SFGR) in sub-Saharan Africa. We sought to identify SFGR Kilimanjaro Region, Tanzania. Methods recruited febrile patients presenting at 2 hospitals Moshi from February 2012 through May 2014. Standardized clinical and factor questionnaires were administered. exposure was defined as a Rickettsia africae immunofluorescence antibody reciprocal titer ≥64, acute ≥4-fold rise between paired sera. Logistic...
Background: Due to their non-specific clinical presentation, acute febrile illnesses (AFI) are often diagnosed clinically as diseases known be endemic the region in which they found. Uganda has been site of multiple emerging-disease outbreaks, and there several that present with undifferentiated AFI, requiring further laboratory confirmation; however, limited capacity can impair timely diagnosis public health interventions. This results misdiagnosis underreporting emerging importance. The...