A5077466592- Immunodeficiency and Autoimmune Disorders
- Health and Medical Studies
- Medical Coding and Health Information
- Genomics and Rare Diseases
- Chronic Disease Management Strategies
- Blood groups and transfusion
- Cystic Fibrosis Research Advances
- Renal and related cancers
- Genomic variations and chromosomal abnormalities
- Clinical practice guidelines implementation
- Ion Transport and Channel Regulation
- Biomedical Text Mining and Ontologies
- Neurogenetic and Muscular Disorders Research
- Pediatric Urology and Nephrology Studies
- Linguistic research and analysis
- Digitalization, Law, and Regulation
- Genetic and Kidney Cyst Diseases
- Diverse Scientific and Economic Studies
- Digestive system and related health
- Youth Substance Use and School Attendance
- Occupational and environmental lung diseases
- Urological Disorders and Treatments
- Immune Cell Function and Interaction
- Medical and Health Sciences Research
- Medical Practices and Rehabilitation
Federal Institute for Drugs and Medical Devices
2021-2024
Klinik und Poliklinik für Kinder- und Jugendmedizin
2023
Universitätsklinikum Gießen und Marburg
2020
Deutsche Gesellschaft für Information und Wissen
2006-2019
Amgen (Switzerland)
2019
Universitätskinderklinik
1981-2017
Philipps University of Marburg
2016
Essen University Hospital
2013-2015
Zentrum für Kinderheilkunde
2014
Adipositas Zentrum Oberhausen
2013
Estimates of rare disease (RD) population impact in terms number affected patients and accurate definition is hampered by their under-representation current coding systems. This study tested the use a specific RD codification system (ORPHAcodes) five European countries/regions (Czech Republic, Malta, Romania, Spain, Veneto region-Italy) across different data sources over period January 2019-September 2021.Overall, 3133 ORPHAcodes were used to describe diagnoses, mainly corresponding...
Abstract Background In European Union countries, any disease affecting less than 5 people in 10,000 is considered rare. As expertise scarce and rare diseases (RD) are complex, RD patients can remain undiagnosed for many years. The period of searching a diagnosis, called diagnostic delay, sometimes leads to dead end when the patient’s impossible diagnose after undergoing all available investigations. recent years, extensive efforts have been made support implementation ORPHA nomenclature...
In vivo exposure of rat lungs to crystalline silica either by intratracheal instillation or inhalation results in an increase mRNA levels for inducible nitric oxide synthase (iNOS) bronchoalveolar lavage cells (BALC), elevated (.NO) production BALC, and .NO-dependent chemiluminescence (CL) from alveolar macrophages (AM). Induction iNOS message occurs both AM polymorphonuclear leukocytes (PMN) harvested silica-exposed but is not significantly lavaged lung tissue. vitro does stimulate .NO...
This consensus-based guideline was developed by all relevant German pediatric medical societies. Ultrasound is the standard imaging modality for pre- and postnatal kidney cysts should also exclude extrarenal manifestations in abdomen internal genital organs. MRI has selected indications. Suspicion of a cystic disease prompt consultation nephrologist. Prenatal management must be tailored to very different degrees severity. After renal oligohydramnios, we recommend delivery perinatal center....
In Germany all physicians are compelled to code according the International Statistical Classification of Diseases and Related Health Problems, 10th revision, German Modification (ICD-10-GM), Statutory Insurance. The classification is in use since 2004 same Version for inpatient outpatient care. Special coding guidelines be used care. DIMDI provides an Index ICD-10-GM, which contains approx. 80.000 terms. For electronic index published with a unique identifier (so called Alpha-ID). This...
The mechanism of bleomycin-induced pulmonary fibrosis is not yet clear. Recent studies have shown that alveolar macrophages (AM) can be stimulated by bleomycin in vitro releasing inflammatory cytokines, suggesting the interaction with AM an important step drug-induced fibrotic process. Bleomycin known to bind DNA and generate oxygen radicals through complexation Fe2+ oxygen. To provide more insight into cellular oxidative property bleomycin, we developed a fluoromicroscopic method using...
Arachidonic acid metabolites such as prostaglandins, thromboxanes, and leukotrienes are well known modulators of intestinal vascular perfusion, motility, electrogenic ion transport. We investigated the effect different hydroxyeicosatetraenoic acids (HETEs) from cytochrome P450- lipoxygenase-dependent arachidonate metabolism on chloride secretion in rat distal colon. Using conventional Ussing techniques, basolateral 12-HETE significantly decreased basal short-circuit current (I(sc)) inhibited...
Kurzfassung Ausgangpunkt einer effizienten Prozessgestaltung ist häufig die Montage, auf Grund des hohen Anteils manueller Tätigkeiten und der großen Verantwortung für Produktqualität, Herstellkosten Liefertreue großes Verbesserungspotenzial verspricht. Der Wunsch nach stetig verbesserten Arbeitssystemen, Standardisierung Transparenz im Sinne schlanken Produktion stellt jedoch auch hohe Anforderungen an Prozessqualität Effizienz Produktionslogistik. Das Material muss zuverlässig...