A5087598723- Forensic and Genetic Research
- Genetic diversity and population structure
- Chromosomal and Genetic Variations
- Forensic Anthropology and Bioarchaeology Studies
- Genomics and Chromatin Dynamics
- Ancient and Medieval Archaeology Studies
- Archaeology and ancient environmental studies
- Machine Learning in Bioinformatics
- Fractal and DNA sequence analysis
- CRISPR and Genetic Engineering
- Yersinia bacterium, plague, ectoparasites research
- Genomics and Phylogenetic Studies
- Molecular Biology Techniques and Applications
- RNA Research and Splicing
- Eurasian Exchange Networks
- Developmental Biology and Gene Regulation
- Animal Diversity and Health Studies
- Soviet and Russian History
- Historical and Archaeological Studies
- Insect and Arachnid Ecology and Behavior
- Neurobiology and Insect Physiology Research
- Animal Genetics and Reproduction
- Metabolomics and Mass Spectrometry Studies
- Plant Molecular Biology Research
- Cancer-related gene regulation
University of Szeged
2016-2025
Hungarian Academy of Sciences
1995-2005
Institute of Genetics
1997-2005
HUN-REN Szegedi Biológiai Kutatóközpont
1997-2005
Research Institute of Molecular Pathology
2002-2005
University of California, Irvine
1997
University of California, Los Angeles
1996
DKFZ-ZMBH Alliance
1995
German Cancer Research Center
1995
Adhesion molecules of the cadherin superfamily have an important role during vertebrate development. The DE-cadherin homolog is first classic isolated from invertebrates. We report here that encoded by shotgun (shg) gene. shg expressed in most embryonic epithelia and decreases cells undergo epithelial-mesenchymal transitions like mesoderm or neural precursors. Removal both maternal zygotic function leads to severe defects all expressing shg, suggesting DE-cadherin, similar cadherins, has a...
Abstract A single P-element insertional mutagenesis experiment was carried out for the second chromosome of Drosophila melanogaster using P-lacW transposon. Out 15,475 insertions on chromosome, 2,308 lethal and 403 semilethal mutants (altogether 2,711) were recovered. After eliminating clusters, 72% represent independent insertions. Some with larval, prepupal or pupal phases have a prolonged larval period show gradual overgrowth imaginal discs, brain and/or hematopoietic organs (lymph...
Huns, Avars, and conquering Hungarians were migration-period nomadic tribal confederations that arrived in three successive waves the Carpathian Basin between 5th 9th centuries. Based on historical data, each of these groups are thought to have from Asia, although their exact origin relation other ancient modern populations been debated. Recently, hundreds genomes analyzed Central Mongolia, China, which we aimed identify putative source for above-mentioned groups. In this study, sequenced 9...
Patterning of the neural tube establishes midbrain and hindbrain structures that coordinate motor movement, process sensory input, integrate cognitive functions. Cellular impairment within these underlie diverse neurological disorders, in vitro organoid models promise inroads to understand development, model disease, assess therapeutics. Here, we use paired single-cell transcriptome accessible chromatin sequencing map cell composition regulatory mechanisms hindbrain. We find existing...
Abstract Hun, Avar and conquering Hungarian nomadic groups arrived to the Carpathian Basin from Eurasian Steppes significantly influenced its political ethnical landscape, however their origin remains largely unknown. In order shed light on genetic affinity of above we have determined Y chromosomal haplogroups autosomal loci, suitable predict biogeographic ancestry, 49 individuals, supposed represent power/military elit. Haplogroups Hun-age are consistent with Xiongnu ancestry European Huns....
The tumor suppressor gene overgrown hematopoietic organs-31 (oho31) of Drosophila encodes a protein with extensive homology to the Importin Xenopus (50% identity), related yeast SRP1 protein, and mammalian hSRP1 RCH1 proteins. A strong reduction in expression oho31 by P element inserted 5' untranslated region transcript or complete inactivation imprecise excision leads malignant development organs genital disc, as shown their growth autonomy transplantation assays. We have cloned...
It has been widely accepted that the Finno-Ugric Hungarian language, originated from proto Uralic people, was brought into Carpathian Basin by conquering Hungarians. From middle of 19th century this view prevailed against deep-rooted Hun tradition, maintained in folk memory as well and foreign written medieval sources, which claimed Hungarians were kinsfolk Huns. In order to shed light on genetic origin Conquerors we sequenced 102 mitogenomes early Conqueror cemeteries compared them...
Abstract Kinship analysis from very low-coverage ancient sequences has been possible up to the second degree with large uncertainties. We propose a new, accurate, and fast method, correctKin, estimate kinship coefficient confidence interval using data. perform simulations also validate correctKin on experimental modern data widely different genome coverages (0.12×–11.9×) samples known family relations known/unknown population structure. Based our results, allows for reliable identification...
As part of the effort to create a high resolution representative sequence database medieval Hungarian conquerors we have resequenced entire mtDNA genome 24 published ancient samples with Next Generation Sequencing, whose haplotypes had been previously determined traditional PCR based methods. We show that methods are prone erroneous haplotype or haplogroup determination due ambiguous reads, and many classified inaccurately. The SNaPshot method applied DNA authenticity criteria is most...
Homozygosity for a null mutation in the proliferation disrupter (prod) gene of Drosophila causes decreased mitotic index, defects anaphase chromatid separation, and imperfect chromosome condensation larval neuroblasts other proliferating cell populations. The defective is especially obvious near centromeres. Mutant larvae show slow growth massive death populations, followed by late lethality. Loss prod function clones leads to arrest oogenesis ovary cuticle formation imaginal disc...
Nomadic groups of conquering Hungarians played a predominant role in Hungarian prehistory, but genetic data are available only from the immigrant elite strata. Most 10–11th century remains Carpathian Basin belong to common people, whose origin and relation have been widely debated. Mitogenome sequences were obtained 202 individuals with next generation sequencing combined hybridization capture. Median joining networks used for phylogenetic analysis. The commoner population was compared 87...
Abstract For decades, there has been scientific interest in the variation and geographic distribution of paternal lineages associated with human Y chromosome. However, relevant data have dispersed across numerous publications, making it difficult to consolidate. Additionally, understanding relationships between different variants, tools used analyze them, evolved over time, further complicating efforts harmonize this information. The Universal Y-SNP Database (UYSD) marks a substantial...
Tuberculosis (TB) is a bacterial infection that well-known in the palaeopathological record because it can affect skeleton and consequently leaves readily identifiable macroscopic alterations. Palaeopathological case studies provide invaluable information about spatio-temporal distribution of TB past. This true for those archaeological periods geographical regions from when where no or very few cases have been published until now–as Sarmatian period (1 st –5 th centuries CE) Barbaricum...
Mutations in a gene (Klp38B) encoding novel kinesin-like protein Drosophila melanogaster lead to the formation of polyploid cells larval central nervous system and follicle adult egg chambers. Some homozygous mutants survive adulthood also exhibit morphological defects indicative abnormal cell cycle progression, including rough eyes, missing bristles, abdominal cuticles. In brains, there is no accumulation mitotic frequency anaphase figures comparable wild type, suggesting that nuclear...
Cell mediated immunity of the honey bee (Apis mellifera) involves activity several hemocyte populations, currently defined by morphological features and lectin binding characteristics. The objective present study was to identify molecular markers capable characterizing subsets hemocytes. We developed employed monoclonal antibodies with restricted reactions functionally distinct subpopulations. Melanizing cells, known as oenocytoids, were an antibody prophenoloxidase, aggregating cells...
The proliferation disrupter (prod) gene of Drosophila melanogaster encodes a novel protein associated with centromeric chromosomal regions that is required for chromatin condensation and cell viability. We have examined the binding Prod to DNA in vitro. Co-immunoprecipitation experiments demonstrate DNA-binding specifically recognizes 10 bp AGAATAACAT satellite repeat D.melanogaster. Footprinting show interacts 5-8 target sequence each suggest it can mediate this into superhelix. Gel...
The Hunyadi family is one of the most influential families in history Central Europe 14th–16th centuries. family's prestige was established by Johannes Hunyadi, a Turk-beater who rose to position governor Kingdom Hungary. His second son, Matthias became elected ruler Hungary 1458. had unknown origin. Moreover, failed found dynasty because lacking legitimate heir and his illegitimate son Corvinus unable obtain crown. grandson, Christophorus Corvinus, died childhood, thus direct male line...