A5047390589- Animal Genetics and Reproduction
- Chromosomal and Genetic Variations
- Genetic Mapping and Diversity in Plants and Animals
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Genetic and phenotypic traits in livestock
- Genomics and Phylogenetic Studies
- Human-Animal Interaction Studies
- Veterinary Medicine and Surgery
- Cancer-related molecular mechanisms research
- Urological Disorders and Treatments
- Genomics and Chromatin Dynamics
- Molecular Biology Techniques and Applications
- Skin and Cellular Biology Research
- Sperm and Testicular Function
- Veterinary Oncology Research
- Neurological diseases and metabolism
- melanin and skin pigmentation
- Virus-based gene therapy research
- Rabbits: Nutrition, Reproduction, Health
- Primate Behavior and Ecology
- Sexual Differentiation and Disorders
- Veterinary Equine Medical Research
- Genetic diversity and population structure
- Wildlife Ecology and Conservation
- Testicular diseases and treatments
University of Zurich
2012-2024
Farm Africa
2024
Center for Clinical Studies
2018
École Polytechnique Fédérale de Lausanne
1999-2011
University of Veterinary Medicine
2010
University of Veterinary Medicine Hannover, Foundation
2010
National Research Institute of Animal Production
2009
ETH Zurich
1999-2006
Texas A&M University
1994-1997
The dog was the first domesticated animal but it remains uncertain when domestication process began and whether occurred just once or multiple times across Northern Hemisphere. To ascertain value of modern genetic data to elucidate origins domestication, we analyzed 49,024 autosomal SNPs in 1,375 dogs (representing 35 breeds) 19 wolves. After combining our with previously published data, contrasted signatures 121 breeds a worldwide archeological assessment earliest remains. Correlating...
Hereditary footpad hyperkeratosis (HFH) represents a palmoplantar hyperkeratosis, which is inherited as monogenic autosomal recessive trait in several dog breeds, such e.g. Kromfohrländer and Irish Terriers. We performed genome-wide association studies (GWAS) both breeds. In we obtained single strong signal on chromosome 5 (praw = 1.0×10−13) using 13 HFH cases 29 controls. The replicated an independent cohort of Terriers with 10 21 controls 6.9×10−10). analysis shared haplotypes among the...
Thirty-six cats with bronchogenic carcinoma metastatic to the digit were identified. The mean age was 12.7 years, no breed or sex predilection. Records from 19 cases available for review. These presented a primary complaint of lameness that involved primarily weight-bearing digits and third phalanx. None had respiratory signs, despite presence pulmonary carcinoma. Course disease consistent in cases, survival time 58 days initial presentation. Amputation affected rarely palliative due...
Melanoma is a disease with high incidence in gray horses and has limited therapeutic options metastatic disease. Gene therapy shown some success animal models human patients. A randomized double-blind, placebo-controlled study was conducted to investigate 2 treatment using cytokine-encoding plasmid DNA melanoma induce immunologic antitumor effects. Adult spontaneously occurring (n=26) were included the study. Treatment of 26 consisted interleukin-18-encoding DNA, interleukin-12-encoding or...
Introduction Monorchidism is a rarely described condition in the horse and not to be confused with cryptorchidism. The diagnosis challenging confirmed by surgery histology combination hormonal assays. This report describes, best of author’s knowledge, first case monorchidism abdominal cryptorchidism developed testicle horse. Methods An Irish Cob underwent laparoscopic castration for removal bilateral cryptorchid testicles. At was diagnosed as monorchid retained intra-abdominally....
In domestic goats, the polled intersex syndrome (PIS) refers to XX female-to-male sex reversal associated with absence of horn growth (polled). The causal variant was previously reported as a 11.7 kb deletion at approximately 129 Mb on chromosome 1 that affects transcription both FOXL2 and several long non-coding RNAs. meantime presence different versions PIS postulated trials establish genetic testing existing molecular information failed. Therefore, we revisited this by long-read...
Tracing maternal and paternal lineages independently to explore breeding systems dispersal strategies in natural populations has been high on the wish-list of evolutionary biologists. As males are heterogametic sex mammals, such sex-specific patterns can be indirectly observed when Y chromosome polymorphism is combined with mitochondrial sequence information. Over past decade, Y-chromosomal markers applied human have revealed remarkable differences demographic history behaviour between...
Black and tan animals have tan-coloured ventral body surfaces separated by sharp boundaries from black-coloured dorsal surfaces. In the at mouse mutant, a retroviral 6 kb insertion located in hair cycle-specific promoter of murine Asip gene encoding agouti signalling protein causes black phenotype. rabbits, three ASIP alleles are thought to exist, including an allele causing coat colour that closely resembles The goal our study was identify functional genetic variant rabbit allele. We...
Fluorescent in situ hybridisation (FISH) using a panel of molecular probes for all chromosome pairs obtained by microdissection the domestic horse ( Equus caballus ) was used to diagnose karyotype abnormalities 35 horses (32 mares, 2 stallions and 1 intersex), which were selected study due infertility (23 horses), reduced fertility (10 horses) developmental anomalies (2 horses). The use FISH technique with each pair enabled diagnosis many different aberrations this population. Among...
Belted cattle have a circular belt of unpigmented hair and skin around their midsection. The is inherited as monogenic autosomal dominant trait. We mapped the causative variant to 37 kb segment on bovine chromosome 3. Whole genome sequence data 2 belted 130 control yielded only one private genetic in critical interval two animals. belt-associated was copy number (CNV) involving quadruplication 6 non-coding located approximately 16 upstream TWIST2 gene. Increased numbers at this CNV were...
The insulin-like factor 3 (INSL3 or relaxin-like factor) is a hormone produced mainly in gonadal tissues males and females. Deletion of INSL3 its receptor male mice leads to the undescended testes, cryptorchidism. Here we describe an isolation analysis full-length canine gene. gene composed two exons within small genomic region. Putative translation isolated cDNA yields 132 amino acid preproINSL3 that has domain structure characteristic for insulin-relaxin peptide superfamily with...
Cytogenetic and molecular genetic studies of an intersex horse have been carried out. The investigated animal had overall male body conformation; however, its external genitalia consisted incompletely developed vulva penis. X Y chromosome painting probes detected three cell lines in the examined horse: 63,X, 64,XX 65,XX with a fragment (del Y). DNA analysis PCR PCR/RFLP methods showed absence <i>SRY,</i><i>AMELY</i> and<i> ZFY</i> genes as well six...
The aim of our study was to diagnose aneuploidy in equine spermatozoa by multicolour fluorescence situ hybridization (FISH) technique using specific molecular probes for sex chromosomes and autosome pair four (EGFR probe) labeled different fluorochromes. These were applied on decondensed stallions. In total, more than 8800 sperm cells examined. total frequency aberrant 0.496%: XX (0.135%), YY (0.023%), XY (0.102%), diploidy (0.057%), lack chromosome (0.18%). one stallion the ratio normal X-...
A 23-month-old tomcat was referred to our clinic because of male behavioral problems, cryptorchidism, and an undefined intra-abdominal organ resembling a uterus. Ultrasonography computed tomography showed 2 fluid-filled tubular structures dorsolaterally the bladder connected pelvic urethra. The cat castrated, were surgically removed. Histology identified them as Müllerian duct remnants. testes hypoplastic, epididymes deferent ducts normal. Cytogenetic analyses revealed presence mosaic...
An infertile mare with hypoplastic ovaries was subjected to cytogenetic analysis. Fluorescence in situ hybridisation (FISH) using the equine X whole chromosome painting probe (WCPP) carried out on a preparation obtained from blood lymphocyte culture. The number of analysed spreads high (235) and aneuploidy mosaic form diagnosed. karyotype formula 63,X / 64,XX 65,XXX. ratio three lines 15%, 82% 3%, respectively. application FISH technique WCPP is discussed.
Pelger-Huët anomaly (PHA) in humans is an autosomal dominant hematological phenotype without major clinical consequences. PHA involves a characteristic hyposegmentation of granulocytes (HG). Human caused by heterozygous loss function variants the LBR gene encoding lamin receptor B. Bi-allelic and complete deficiency cause much more severe Greenberg skeletal dysplasia which lethal utero characterized massive malformation gross fetal hydrops. HG phenotypes have also been described domestic...
Summary We have constructed a canine bacterial artificial chromosome library amenable to PCR screening. The consists of 96 768 clones and was initially screened with 112 microsatellites representing all chromosomes. For 87 primer sets (77%) one seven positive superpools were identified. will be expanded by adding additional in order increase the genome coverage. Interested researchers can access following rules published at http://www.dogmap.ch .
Since 1956, when the Basle Zoo (Switzerland) initiated breeding of lesser kudu (Tragelaphus imberbis), 43% juveniles died before reaching an age 6 mo. In this study, objective was to obtain pathological findings, nutritional history, and family tree information in order evaluate influence husbandry on juvenile mortality these animals. The main cause death white muscle disease (WMD), diagnosed 14 cases (26%) deceased juveniles. Although enclosure size had remained constant animal...
The objective of this study was to investigate whether the occurrence cryptorchidism in a litter is associated with sex ratio litter. analysis included for dog 1,339 litters 4 different breeds, which 12.8% had 1 and 3.1% 2 cryptorchids, pig 119,920 14 populations, 2.2% 0.2% cryptorchids. data were analyzed using GLIMMIX procedure SAS. In dog, presence cryptorchids does not affect size or stillborn rate. pig, increases significantly an increasing number rate larger than without To...
To aid in the rapid diagnosis of myxomatosis rabbits, a real-time polymerase chain reaction (PCR) for specific detection Myxoma virus is described. Primers and probe were designed to amplify 147-bp fragment within Serp2 gene. The assay was able detect 23 copies synthesized oligo indicating reliable sensitivity. In addition, PCR did not Rabbit fibroma used vaccines. novel shown be fresh paraffin-embedded rabbit tissues originating from cases various regions Switzerland.