A5101567949- Animal Virus Infections Studies
- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Microbial infections and disease research
- Viral gastroenteritis research and epidemiology
- Autophagy in Disease and Therapy
- Nail Diseases and Treatments
- Virus-based gene therapy research
- Aquaculture disease management and microbiota
- Animal Disease Management and Epidemiology
- Virology and Viral Diseases
- Mosquito-borne diseases and control
- Sepsis Diagnosis and Treatment
- Viral Infections and Vectors
- Bacteriophages and microbial interactions
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Inflammasome and immune disorders
- Herpesvirus Infections and Treatments
- interferon and immune responses
- Immune Response and Inflammation
- Bacterial biofilms and quorum sensing
- Reproductive tract infections research
- Cannabis and Cannabinoid Research
- Advanced Glycation End Products research
- Rabies epidemiology and control
Affiliated Hospital of Nantong University
2025
Nantong University
2025
Sichuan Agricultural University
2009-2025
Ministry of Agriculture and Rural Affairs
2024
Ningxia Medical University
2022
Capital Medical University
2019
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2018
Southern Medical University
2015
Nanfang Hospital
2015
// Xixian Li 1 , Zhi Zeng Qingman Qiulin Xu Jiahe Xie Huixin Hao Guangjin Luo Wangjun Liao 2 Jianping Bin Xiaobo Huang Yulin State Key Laboratory of Organ Failure Research, Department Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China Oncology, Correspondence to: Huang, e-mail: chw47922@163.com Liao, liao18@msn.com Keywords: Pathology Section, microRNA, cardiomyocytes, ischemia reperfusion, apoptosis, autophagy Received: May 28, 2015 Accepted: July 20,...
Background and Purpose Targeted modulation of autophagy induced by myocardial ischaemia/reperfusion has been the subject intensive investigation, but it is debatable whether beneficial or harmful. Hence, we evaluated effects pharmacological manipulation on survival cardiomyocytes in different time windows ischaemia/reperfusion. Experimental Approach We examined apoptosis subjected to durations anoxia/re‐oxygenation ischaemia/reperfusion, autophagic enhancer rapamycin inhibitor wortmannin...
Porcine epidemic diarrhea (PED) is an acute, highly contagious, and infectious disease caused by porcine virus (PEDV). PEDV can affect pigs of all ages, with 50~100% mortality in neonatal piglets substantial economic losses the swine industry. In present study, 347 fecal intestinal samples were collected from seven regions China during 2020–2022. A comprehensive molecular investigation spike (S) gene strains was carried out, which included phylogenetic analysis obtained sequences....
This study explored miRNA-126 and HIF-1α levels in patients with OSAHS-related hypertension. To analyze the relationship between hypertension explore pathogenic mechanisms of pathway. The 120 participants were assigned to four groups based on their apnea-hypopnea index (AHI) presence hypertension: healthy control group, non-hypertensive OSAHS 30 objects each group. All subjects underwent overnight sleep monitoring 24-hour (h) ambulatory blood pressure. Their samples analyzed for following...
We report here a clinical case of phaeohyphomycosis in an 18-year-old male giant panda (Ailuropoda melanoleuca). Skin lesions on the disappeared following 2 months treatment with ketoconazole. Three after discontinuing treatment, there was and mycological relapse. The disease progression no longer responsive to Microscopy polymerase chain reaction (PCR) analysis revealed that infection caused by Cladosporium cladosporioides. A 4-month regime Itraconazole oral solution (700 mg per day)...
The Japanese encephalitis virus (JEV), a zoonotic flavivirus, is Asia’s primary cause of viral encephalitis. JEV induces apoptosis in variety cells; however, the precise mechanisms underlying this resulting from infection remain to be elucidated. Our previous studies showed that proapoptosis gene BAX may have role proliferation. In study, we constructed PK-15 cell line (BAX.KO) with knockout using CRISPR/Cas9. effectively inhibited proliferation JEV, 39.9% decrease protein levels, while...
Actinobacillus pleuropneumoniae is a pathogen that infects pigs and poses serious threat to the pig industry. The emergence of quinolone-resistant strains A.pleuropneumoniae further limits choice treatment. However, mechanisms behind quinolone resistance in remain unclear. genomes ciprofloxacin-resistant strain, A. SC1810 its isogenic drug-sensitive counterpart were sequenced analyzed using various bioinformatics tools, revealing 559 differentially expressed genes. biological membrane,...
As a zoonotic virus, Japanese Encephalitis virus (JEV) poses serious threat to human health and the breeding industry. Regarding mechanism complications of tissue inflammation caused by JEV, such as encephalitis orchitis, there is no effective drug treatment currently, occurrence has not been thoroughly studied. Therefore, it necessary study inflammatory pathway JEV. one key proteins regulating cell death, BCL2 antagonist/killer (BAK) also prerequisite for release cellular factors. We found...
This study investigated the prevalence of antimicrobial resistant Enterococcus faecalis (E. faecalis) from ducks at slaughterhouses, analyzed resistance genes and virulence-associated isolates. Multilocus sequence typing (MLST) was performed to characterize their molecular characteristics. A total 227 E. isolates (67.8%) were obtained cecum (n = 114), cloaca 50), skin 59), rinsed water 4). These exhibited high level against tetracycline (95.6%), doxycycline (94.3%), linezolid (75.8%),...
Pasteurella multocida toxin (PMT) is one of the most important virulence factors type D. infection has caused enormous economic losses in pig farming industry. Although it well known that this bacterial causes progressive atrophic rhinitis, its effects on other organ tissues pigs are unclear. In study, PMT was expressed and purified, cytotoxic four types swine cells, LLC-PK1, PAM, IPEC, ST, were investigated. LLC-PK1 exhibited highest sensitivity to PMT. Our studies revealed a concentration...
The Chinese poultry industry has experienced outbreaks of Newcastle disease (ND) dating back to the 1920s. However, epidemic exhibited a downtrend in recent years. In this study, both observational and genetic data [fusion (F) haemagglutinin-neuraminidase genes (HN)] were analyzed, phylogeographic analysis based on prevalent genotypes virus (NDV) was conducted for better understanding evolution spatiotemporal dynamics ND China. line with observed trend outbreaks, effective population size F...
The YfeA gene, belonging to the well-conserved ABC (ATP-binding cassette) transport system Yfe, encodes substrate-binding subunit of iron, zinc, and manganese in bacteria. As a potential vaccine candidate Glaesserella parasuis, functional mechanisms infection process remain obscure. In this study, vaccination with effectively protected C56BL6 mouse against G. parasuis SC1401 challenge. Bioinformatics analysis suggests that is highly conserved its metal-binding sites have been strictly...
Autophagy plays an important role in the development of Parkinson disease (PD). Previous studies showed that autophagy could protect cells from α -synuclein toxicity and promote functional coupling mitochondria. But it is still a question whether modulating can be used to treat PD. In traditional Chinese medicine, specific herbal complex called Bu Shen Jie Du Fang (BSJDF) has long history treating motor impairments similar disease, while its mechanism unclear. As pilot study, we aimed...
Microsporum gypseum causes dermatomycoses in giant pandas (Ailuropoda melanoleuca). This study aimed to investigate the immune response of M. following deep infection. The degree damage heart, liver, spleen, lungs, and kidneys was evaluated using tissue fungal load, organ index, histopathological methods. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) detected mRNA expression receptors cytokines lung, immunofluorescence staining flow cytometry, were used assess cells...
To assess the prognostic value of Charlson weighted index comorbidities (WIC) combined with sequential organ failure assessment (SOFA) score and procalcitonin (PCT) in sepsis patients intensive care unit (ICU).A prospective cohort study was conducted. 118 admitted to ICU Sichuan Provincial People's Hospital from July 2015 June 2018 were enrolled. The clinical data including gender, age, pathogenic factors, site infection, underlying diseases 28-day prognosis collected, while WIC at...
(1) Background: Porcine Parvovirus (PPV) is a single-stranded DNA virus without envelope which causes great harm in relation to porcine reproductive disorders clinic. Cluster of Differentiation 38 (CD38) transmembrane protein widely existing mammals. Its various functions make it very popular research object, including the viral infection field. (2) Methods: Western blotting and an EdU Cell Proliferation Kit were used evaluate effect CD38-deficient cells. Relative quantitative real-time...