A5086842557- Congenital Heart Disease Studies
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Cardiac Structural Anomalies and Repair
- Pulmonary Hypertension Research and Treatments
- Mechanical Circulatory Support Devices
- Cardiac Valve Diseases and Treatments
- Hematopoietic Stem Cell Transplantation
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Immune Cell Function and Interaction
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Cardiovascular Issues in Pregnancy
- Cardiovascular Syncope and Autonomic Disorders
- Coronary Artery Anomalies
- Ion channel regulation and function
- Vascular anomalies and interventions
- Acute Lymphoblastic Leukemia research
- Transplantation: Methods and Outcomes
- Cardiovascular Conditions and Treatments
- Immune Response and Inflammation
- Tracheal and airway disorders
- Aortic Disease and Treatment Approaches
- Congenital Diaphragmatic Hernia Studies
Olgahospital
2005-2025
Klinikum Stuttgart
2023-2025
Universitätsklinikum Aachen
2017-2024
RWTH Aachen University
2017-2023
Günter-Köhler-Institut für Fügetechnik und Werkstoffprüfung
2020
Justus-Liebig-Universität Gießen
2013-2019
Klinik und Poliklinik für Kinder- und Jugendmedizin
2010-2016
Universitätsklinikum Gießen und Marburg
2015
University of Tübingen
2005-2015
Zentrum für Kinderheilkunde
2010-2015
Abstract Background Human multipotent mesenchymal stromal cells (MSC) can be isolated from various tissues including bone marrow. Here, MSC participate as lining in the formation of hematopoietic stem cell niche. In this compartment, oxygen tension is low and partial pressure estimated to range 1% 7%. We analyzed effect tensions on human cultured with platelet-lysate supplemented media assessed proliferation, morphology, chromosomal stability, immunophenotype plasticity. Results After...
Background— We evaluated the effects of site ventricular pacing on left (LV) synchrony and function in children requiring permanent pacing. Methods Results— One hundred seventy-eight (aged <18 years) from 21 centers with atrioventricular block a structurally normal heart undergoing were studied cross-sectionally. Median age at evaluation was 11.2 (interquartile range, 6.3–15.0) years. duration 5.4 3.1–8.8) Pacing sites free wall right (RV) outflow tract (n=8), lateral RV (n=44), apex...
Summary Minimal (i.e. submicroscopic) residual disease (MRD) predicts outcome in childhood acute lymphoblastic leukaemia (ALL). To be used clinically, MRD assays must reliable and accurate. Two well‐established techniques, flow cytometry (FC) polymerase chain reaction (PCR), can detect leukaemic cells with a sensitivity of 0·01% (10 −4 ). We analysed diagnostic samples 45 ALL‐patients (37 B‐lineage ALL, eight T‐lineage ALL) by four‐colour FC real‐time PCR. Leukaemia‐associated...
Endoluminal pulmonary banding and duct stenting are the basis for nonsurgical, transcatheter stage I in newborns with hypoplastic left heart syndrome (HLHS).We report a novel, nonsurgical palliation HLHS variants. 1 The aim of our approach is to replace Norwood open-chest hybrid procedures, 2 as well complex neonatal biventricular repairs, enable comprehensive II or repair lower overall risk by postponing surgeries later infancy.Following institutional guidelines, this compassionate...
In acute myeloid leukemia (AML), the leukemia-initiating cell is found within CD34+/CD38− compartment. Over last years evidence grew that AML initiated and propagated by leukemic stem cells (LSCs). Conceivably, these most immature are more resistant to therapy subsequently initiate relapse. The authors studied 17 patients with childhood treated according AML-BFM 98/04 protocol. At diagnosis, determined characteristic immunophenotype of flow cytometry investigated expression CD34, CD38, CD45...
Background Aortopulmonary collaterals (APCs) are frequently found in patients with a single-ventricle (SV) circulation. However, knowledge about the clinical significance of systemic-to-pulmonary shunt flow after modified Fontan procedure and its potential causes is limited. Accordingly, aim our study was to detect quantify APC using cardiovascular magnetic resonance (CMR) assess impact on SV volume function as well evaluate role size pulmonary arteries regard development APCs. Methods 60...
Objectives We report our experience with a transcatheter technique to bypass the lung and thus improve single‐ventricle preload reduce venous congestion in Fontan patients. Background In absence of dedicated power source serve pulmonary circulation significantly elevated transpulmonary pressure gradient, fenestration is an option hemodynamics patients by relieving excessive systemic pressure. Methods Results From 2005 2011, 22 fenestrations were performed without any major complications 19...
Background: Since patients with congenital heart defects (CHD) frequently require life-long medical care and repeat invasive treatment, radiation exposure during interventional procedures is a relevant issue concerning potential related risks. Therefore, an analysis on data from the German Registry for Cardiac Operations Interventions in CHD was performed. Methods: From January 2012 until December 2020 total of 28,374 cardiac catheter interventions were recorded. 8 specified selected...
Background Right ventricular outflow tract (RVOT) stenosis after repair of tetralogy Fallot has been linked with favorable right remodeling but adverse outcomes. The aim our study was to assess the hemodynamic impact and prognostic relevance pressure load in this population. Methods Results A total 296 patients repaired (mean age, 17.8±7.9 years) were included a prospective cardiovascular magnetic resonance multicenter study. Myocardial strain quantified by feature tracking technique at...