A5056749580- Cancer Cells and Metastasis
- Microtubule and mitosis dynamics
- Cancer Genomics and Diagnostics
- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Breast Cancer Treatment Studies
- Cerebrospinal fluid and hydrocephalus
- Metabolism, Diabetes, and Cancer
- Estrogen and related hormone effects
- Spinal Dysraphism and Malformations
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Bacterial Infections and Vaccines
- Wnt/β-catenin signaling in development and cancer
- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Global Cancer Incidence and Screening
- Peptidase Inhibition and Analysis
- Angiogenesis and VEGF in Cancer
- Skin and Cellular Biology Research
- Galectins and Cancer Biology
- Prostate Cancer Diagnosis and Treatment
- Cell Adhesion Molecules Research
Shaqra University
2020-2025
University of Nottingham
2018-2024
Nottingham City Hospital
2019
The Ubiquitin-conjugating enzyme 2C (UBE2C) is essential for the ubiquitin-proteasome system and involved in cancer cell migration apoptosis. This study aimed to determine prognostic value of UBE2C invasive breast (BC).UBE2C was evaluated using Molecular Taxonomy Breast Cancer International Consortium (n = 1980), Genome Atlas 854) Kaplan-Meier Plotter 3951) cohorts. protein expression assessed immunohistochemistry BC cohort 619). correlation between UBE2C, clinicopathological parameters...
Lymphovascular invasion (LVI) is a prognostic factor in early-stage invasive breast cancer (BC). Through bioinformatics, data analyses of multiple BC cohorts revealed the positive association between interferon-stimulated gene 15 (ISG15) LVI status. Thus, we explored significance ISG15 BC.
Lymphovascular invasion (LVI) is associated with the development of metastasis in invasive breast cancer (BC). However, complex molecular mechanisms LVI, which overlap other oncogenic pathways, remain unclear. This study, using available large transcriptomic datasets, aims to identify genes LVI early-stage BC patients.
N6-methyladenosine (m6A) is the most abundant internal mRNA modification and dynamically regulated through distinct protein complexes that methylate, demethylate, and/or interpret m6A modification. These proteins, modification, are involved in regulation of gene expression, RNA stability, splicing translation. Given its role these crucial processes, has been implicated many diseases, including cancer development progression. Prostate (PCa) commonly diagnosed non-cutaneous men recent studies...
Background: Ventriculoperitoneal shunting (VPS) is the primary treatment for hydrocephalus, significantly improving patients’ outcomes. However, it marred by high failure rates due to infections, which account a third of these malfunctions and escalate morbidity, mortality, healthcare costs. Method: This study focused on evaluating VPS infection rates, pathogens, their resistance patterns, impact clinical outcomes using retrospective data from multiple hospitals in Saudi Arabia. It included...
Background: Keratin (KRT) 24 is a cytoskeletal protein that plays major role in the formation of intermediate filaments to provide mechanical stability. KRT24 overexpression facilitates tumour-cell migration, invasion and metastasis several types cancers. This study evaluates clinicopathological significance expression large breast cancer (BC) cohorts with long-term follow-up. Methods: mRNA was assessed publicly available BC datasets (n=13,025). evaluated immunohistochemically using...
Prostate cancer (PCa) is one of the most common male cancers and second leading cause cancer-related deaths among males worldwide. Efforts to increase men's awareness, understanding symptoms risk factors, provision early medical assistance are crucial for prevention detection PCa. This study assessed level knowledge, screening PCa participants in Najran, Saudi Arabia. A cross-sectional was conducted with 341 from 19 June 2024 25 September 2024. An online questionnaire used collect data....
The leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) plays a role in immune response homeostasis, extracellular matrix remodelling and it is overexpressed many high-grade cancers. This study aimed to elucidate the biological prognostic of LAIR-1 invasive breast cancer (BC). effect was evaluated at mRNA protein levels using well-characterised multiple BC cohorts. Related signalling pathways were silico differential gene expression siRNA knockdown used for functional analyses. High...
KN motif and ankyrin repeat domains 1 (KANK1) plays an important role in cytoskeleton maintenance contributes to the regulation of cell proliferation, adhesion apoptosis. KANK1 is involved progression a variety solid tumours; however, its invasive breast cancer (BC) remains unknown. This study aims evaluate clinicopathological prognostic value expression operable BC.KANK1 was assessed at transcriptomic level using multiple BC cohorts; Molecular Taxonomy International Consortium cohort...
Cell Division Cycle Associated 5 (CDCA5) plays a role in the phosphoinositide 3-kinase (PI3K)/AKT/mTOR signalling pathway involving cell division, cancer migration and apoptosis. This study aims to assess prognostic biological value of CDCA5 breast (BC).The were evaluated at mRNA (n = 5109) protein levels 614) utilizing multiple well-characterized early stage BC cohorts. The effects knockdown (KD) on oncogenic assays assessed vitro using panel lines.this examined cohorts showed that high...
Abstract Background N6-methyladenosine (m 6 A) is the most common internal RNA modification and involved in regulation of protein expression. AlkB family member 5 (ALKBH5) a m A demethylase. Given important role biological mechanisms, its regulators, have been implicated many disease processes, including cancer. However, contribution ALKBH5 to invasive breast cancer (BC) remains poorly understood. The aim this study was evaluate clinicopathological value BC. Methods Publicly available data...