A5011311095- Antibiotic Resistance in Bacteria
- Pharmaceutical and Antibiotic Environmental Impacts
- Bacterial Identification and Susceptibility Testing
- Pneumonia and Respiratory Infections
- Antibiotics Pharmacokinetics and Efficacy
- Enterobacteriaceae and Cronobacter Research
- Urinary Tract Infections Management
- Antibiotic Use and Resistance
- Family and Disability Support Research
- Family Caregiving in Mental Illness
- Genomics and Phylogenetic Studies
- Reproductive tract infections research
- Nosocomial Infections in ICU
- Antimicrobial Resistance in Staphylococcus
- Healthcare Quality and Management
- Clostridium difficile and Clostridium perfringens research
- Pharmaceutical Practices and Patient Outcomes
- Adolescent Sexual and Reproductive Health
- Vibrio bacteria research studies
- Maternal Mental Health During Pregnancy and Postpartum
- Respiratory and Cough-Related Research
- Primary Care and Health Outcomes
University Hospital Galway
2009-2025
Ollscoil na Gaillimhe – University of Galway
2020
Columbia University Irving Medical Center
2016
Hypervirulent Klebsiella pneumoniae (hv Kp ) has emerged as a pathogen of global concern associated with invasive community-acquired infections. The combination hypervirulence and carbapenem resistance can result in severe difficult-to-treat This retrospective study aimed to investigate the spread hv sequence type 23 (ST23) Ireland convergence hypervirulent (hv) antimicrobial genotypes. Short-read sequences (PE300) for 90 K. ST23 isolates were generated by Galway Reference Laboratory...
Analysis of sequencing data for 143 blaNDM-1- and blaOXA-48-positive Klebsiella pneumoniae isolates from 13 European national collections the public domain resulted in identification 15 previously undetected multi-country transmission clusters. For 10 clusters, cases had prior travel/hospitalisation history countries outside Union including Egypt, Iran, Morocco, Russia, Serbia, Tunisia Turkey. These findings highlight benefit whole genome sequencing-based surveillance sharing control...
The prevalence of infections caused by OXA-48-like carbapenemase-producing organisms in Ireland has increased dramatically since 2011 and is an urgent public health issue. Genome-based high-resolution genotyping was used to analyse clinical isolates submitted the Irish Carbapenemase-Producing Enterobacteriaceae Reference Laboratory Service for a 13 month period (2016-17).A total 109 OXA-48-producing non-duplicate from 16 submitting centres were sequenced. Using gene-by-gene approach, isolate...
Previous studies conducted in Maryland of the Family-to-Family (FTF) education program National Alliance on Mental Illness (NAMI) found that FTF reduced subjective burden and distress improved empowerment, mental health knowledge, self-care, family functioning, establishing it as an evidence-based practice. In study reported here, NAMI–NYC Metro was evaluated. Participants (N=83) completed assessments at baseline completion FTF. had engagement self-care activities, self-perception emotional...
ABSTRACT Carbapenemase-producing Enterobacterales (CPE) is a diverse group of often multidrug-resistant organisms. Surveillance and control infections are complicated due to the inter-species spread carbapenemase-encoding genes (CEGs) on mobile genetic elements (MGEs), including plasmids transposons. Due wastewater discharges, urban water ecosystems represent known reservoir CPE. However, dynamics carbapenemase-bearing MGE dissemination between in humans environmental waters poorly...
There are no prevalence data on Chlamydia trachomatis relating to female students attending higher education available for the Republic of Ireland. This information is required guide necessity screening programmes in settings. research aimed determine and predictive risk factors genital infection among All females presenting during one-day periods at Student Health Units three institutions two cities Ireland were invited participate. Participants completed a questionnaire lifestyle...
The emergence and dissemination of mobile colistin resistance (mcr) genes across the globe poses a significant threat to public health, as remains one last line treatment options for multi-drug resistant infections. Environmental samples (157 water 157 wastewater) were collected in Ireland between 2018 2020. Samples assessed presence antimicrobial bacteria using Brilliance ESBL, CRE, mSuperCARBA McConkey agar containing ciprofloxacin disc. All integrated constructed wetland influent effluent...
The spread of carbapenemase-producing Enterobacterales (CPE) is major public health concern. transmission dynamics CPE in hospitals, particularly at the national level, are not well understood. Here, we describe a retrospective nationwide genomic surveillance study Ireland between 2012 and 2017. We sequenced 746 samples obtained After clustering sequences, used thresholds based on pairwise SNPs, reported within–host diversity along with epidemiological data to infer recent putative...
Abstract Carbapenemase-producing Enterobacterales (CPE) are important globally. In 2017, Ireland declared a national public health emergency to address CPE in acute hospitals. A National Public Health Emergency Team and an expert advisory group (EAG) were established. The EAG has identified key learnings inform future strategies. First, there is still opportunity prevent becoming endemic. Second, damp environmental reservoirs hospitals inadequately controlled. Third, antibiotic stewardship...
Older people residing in care homes need good support and care, as they have a higher level of needs than most the rest population. These are recognised Department Health's National Service Framework for People (2001) being group at risk terms long-term illness, hospitalisation, adverse effects medication falls. In studies medicine-related hospital admissions medicines older people, some consistently rank highly, including psychoactive agents, non-steroidal anti-inflammatory drugs,...
ABSTRACT Clostridioides difficile PCR ribotype (RT) 002 is the second most prevalent RT in Netherlands. In 2019, an increase C. infections (CDI) due to a clonal RT002 strains was reported Ireland. retrospect, significant proportion of CDI detected Netherlands between May 2017-May 2018 (11.9% 683 cases vs 6.5% 865 previous year). Our aim analyze and characterize over time assess whether isolates were related Irish isolates. Over period 2009-April 2021, Dutch patients with showed less severe...
Abstract The emergence and dissemination of mobile colistin resistance ( mcr ) genes across the globe poses a significant threat to public health, as remains one last line treatment options for multi-drug resistant infections. Environmental samples (157 water 157 wastewater) were collected in Ireland between 2018 2020. Samples assessed presence antimicrobial bacteria using Brilliance ESBL, CRE, mSuperCARBA McConkey agar containing ciprofloxacin disc. All integrated constructed wetland...