A5009735474- Sinusitis and nasal conditions
- Head and Neck Surgical Oncology
- Pituitary Gland Disorders and Treatments
- Nasal Surgery and Airway Studies
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Oral and Maxillofacial Pathology
- Surgical Simulation and Training
- Meningioma and schwannoma management
- Pediatric health and respiratory diseases
- Tracheal and airway disorders
- Airway Management and Intubation Techniques
- Mycobacterium research and diagnosis
- Cerebrospinal fluid and hydrocephalus
- Salivary Gland Tumors Diagnosis and Treatment
- COVID-19 and healthcare impacts
- Craniofacial Disorders and Treatments
- Infectious Diseases and Mycology
- Cystic Fibrosis Research Advances
- Cleft Lip and Palate Research
- Respiratory and Cough-Related Research
- Voice and Speech Disorders
- Olfactory and Sensory Function Studies
- Dental Research and COVID-19
- Infection Control and Ventilation
McGill University
2016-2025
McGill University Health Centre
2015-2025
Royal Victoria Hospital
2007-2024
Jewish General Hospital
2003-2021
Montreal Heart Institute
2014
Queen Elizabeth Hospital
2010-2012
Loma Linda University
2012
Loma Linda University Medical Center
2012
The University of Adelaide
2012
Flinders University
2010
Background Endoscopic sinus surgery (ESS) is a technically challenging procedure, associated with significant risk of complications. Virtual reality simulation has demonstrated benefit in many disciplines as an important educational tool for surgical training. Within the field rhinology, there lack ESS simulators appropriate validity evidence supporting their integration into residency education. The objectives this study are to evaluate acceptability, perceived realism and McGill Simulator...
Abstract The sinonasal microbiome remains poorly defined, with our current knowledge based on a few cohort studies whose findings are inconsistent. Furthermore, the variability of sinus across geographical divides unexplored. We characterize and its variations in both health disease using 16S rRNA gene sequencing 410 individuals from world. Although microbial ecology is highly variable between individuals, we identify core comprised Corynebacterium , Staphylococcus Streptococcus Haemophilus...
Endoscopic sinus surgery poses unique training challenges due to complex and variable anatomy, the risk of major complications. We sought create provide validity evidence for a novel 3D-printed simulator nose paranasal sinuses.Sinonasal computed tomography (CT) images patient were imported into 3D visualization software. Segmentation bony soft tissue structures was then performed. The model printed using simulated bone materials. Rhinologists otolaryngology residents completed 6 prespecified...
Background The technical challenges of endoscopic sinus surgery (ESS) and the high risk complications support development alternative modalities to train residents in these procedures. Virtual reality simulation is becoming a useful tool for training skills necessary minimally invasive surgery; however, there are currently no ESS virtual simulators available with valid evidence supporting their use resident education. Our aim was develop new rhinology simulator, as well define potential...
Bicarbonate facilitates mucin unpacking and bacterial killing; however, its transport mechanisms in the airways are not well understood. cAMP stimulates anion efflux through cystic fibrosis (CF) transmembrane conductance regulator (CFTR; ABCC7) channel, this is defective CF. The exchanger pendrin (SLC26A4) also mediates HCO3- upregulated by proinflammatory cytokines. Here, we examined CFTR expression their contributions to secretion human nasal bronchial epithelia. In native tissue, both...
Recent evidence suggests that biologic therapy with targeted activity within the Type 2 inflammatory pathway can improve clinical signs and symptoms of chronic rhinosinusitis nasal polyposis (CRSwNP). There remains a population in CRSwNP despite medical endoscopic sinus surgery have persistent disease. Therefore, biologics, monoclonal antibody agents, could be beneficial therapeutic treatments for these patients. been eight randomized, double-blind, placebo-controlled trails performed...
To evaluate the usefulness of adynamic lateral neck radiographs and dynamic video rhinoscopy in assessing adenoid size relationship these methods to associated symptoms thus severity disease.Children with suspected hypertrophy underwent standard soft tissue radiographs: percentage airway occlusion, nasopharynx (AN) ratio, palate thickness were assessed by a radiologist. The closure was direct fibre-optic an ear, nose, throat clinic. Associated clinical parents using standardized...
Background The purpose of this study was to determine long-term subjective outcome endoscopic sinus surgery (ESS) for chronic sinusitis (CS) and evaluate prognostic indicators surgical treatment failure. Methods This is a prospective patients who underwent ESS CS. Symptom assessment performed using visual analog scale at pretreatment interview then regular intervals post-ESS up 3-year period. symptom scoring were nasal obstruction, facial pain, postnasal drip, anterior discharge,...
This study offers a novel description of the sinonasal microbiome, through an unsupervised machine learning approach combining dimensionality reduction and clustering. We apply our method to International Sinonasal Microbiome Study (ISMS) dataset 410 sinus swab samples. propose three main "microbiotypes" or "states": first is
The airway mucosal microenvironment is crucial for host defense against inhaled pathogens but remains poorly understood. We report here that the surface normally undergoes surprisingly large excursions in pH during breathing can reach 9.0 inhalation, making it most alkaline fluid body. Transient alkalinization requires luminal bicarbonate and membrane-bound carbonic anhydrase 12 (CA12) antimicrobial. Luminal concentration CA12 expression are both reduced cystic fibrosis (CF), mucus...
OBJECTIVE Previous studies have established the efficacy of post‐thyroidectomy hypocalcemia monitoring using parathyroid hormone (PTH) and corrected calcium levels at 1 6 hours. The goal this study was to measure impact managing patients based on above findings with respect to: duration hospital stays, rates transient hypocalcemia, number blood tests, cost savings, discharge from as early 8 hours without compromising safety. STUDY DESIGN AND SETTING This is a prospective involving 95 total...
Abstract Objectives/Hypothesis: To compare surgical outcomes of primary powered endoscopic dacryocystorhinostomy (DCR) with selective or routine silicone stenting in anatomic and functional nasolacrimal duct obstruction (NLDO). Study Design: Prospective nonrandomized cohort study historical control group. Methods: Thirty‐one consecutive DCR procedures were performed for NLDO. No was used unless a tight Rosenmuller valve appreciated when probing system during surgery. Nasolacrimal irrigation,...
Objectives/Hypothesis Trigeminal sensation (TS) within the nasal cavity is important for perception of airflow. The objective this study to examine whether impaired TS contributes obstruction in patients with chronic rhinosinusitis (CRS). Study Design Prospective case‐control conducted a tertiary referral rhinology clinic. Methods Cases consisted CRS subjective obstruction, not previously treated oral corticoids. Controls without CRS. Neither group demonstrated obvious anatomical...
Chronic rhinosinusitis (CRS) is among the three most common chronic diseases in North America. The area of proteomics research providing tremendous insight into mechanisms a variety physiological processes and disease states. purpose this study was to evaluate qualitative quantitative differences protein content nasal mucus patients with hypertrophic sinusitis polyposis when compared control subjects.A case-control performed tertiary academic center. Nasal collected from four CRS as well...
Background Inadvertent injury to the internal carotid artery (ICA), if poorly managed, not only presents a risk of exsanguination but can also result in significant long‐term morbidity. Through implementation novel animal model endoscopic (CAI), effective techniques manage this scenario have been developed. The Vascular Injuries Workshop has trained over 110 surgeons these techniques. This study reviews events major arterial hemorrhage managed by who completed vascular workshop training....
Adequate surgical field visualization is among the most important factors in preventing complications functional endoscopic sinus surgery (FESS). The aim of this study was to assess effect topical cocaine vs adrenaline on and intraoperative bleeding during FESS.A randomized controlled trial conducted. A total 37 patients that underwent FESS for chronic rhinosinusitis were side nose received or cocaine-soaked patties, operated first. surgeon evaluating blinded vasoconstrictor allocation. At...
Providing alternative training modalities may improve trainees' ability to perform septoplasty. Three-dimensional printing has been shown be a powerful tool in surgical training. The objectives of this study were explain the development our 3-dimensional (3D) printed septoplasty model, assess its face and content validity, present evidence supporting distinguish between levels proficiency.Imaging data patient with nasal septal deviation was selected for printing. Printing materials...
Background There are many standard repair options for choanal atresia including puncture, dilatation and drilling of the atretic plate. Most these techniques involve postoperative stenting, which may promote granulation scarring, with possible progression to restenosis. This article describes a novel approach without stenting. Methods our experience this technique utilized in 16 pediatric patients 1 adult patient across multiple tertiary rhinology centers during 2008 through 2015. Seven...
Advancements in endoscopic sinus and skull base surgery created a need for standardized terminology to describe sphenoid surgery. Although classification systems exist other sinuses, one is lacking. Developing such system would standardize procedure descriptions promote common language among surgeons. This study aimed develop new Consensus on novel by running the Delphi with 16 rhinology experts from around world. Four rounds were required reach consensus all stages of classification. The...
We report the case of a 43-year-old male who presented with 2-year history frequent frontal headaches, initially attributed to sinus disease. Magnetic resonance imaging revealed 30 mm mass in right sphenoid extension into cavernous sinus, encasing internal carotid artery, and invading sella turcica. Differential diagnosis based on included meningioma, low-grade carcinoma, or lymphoma. An endoscopic biopsy identified lesion as silent corticotroph pituitary neuroendocrine tumor/adenoma (SCA),...