A5073116220- Anesthesia and Pain Management
- Anesthesia and Sedative Agents
- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiac, Anesthesia and Surgical Outcomes
- Nausea and vomiting management
- Airway Management and Intubation Techniques
- Organ Transplantation Techniques and Outcomes
- Respiratory Support and Mechanisms
- Liver Disease and Transplantation
- Traumatic Brain Injury and Neurovascular Disturbances
- Tracheal and airway disorders
- Hemodynamic Monitoring and Therapy
- Pediatric Pain Management Techniques
- Pain Management and Opioid Use
- Liver Disease Diagnosis and Treatment
- S100 Proteins and Annexins
- Spine and Intervertebral Disc Pathology
- Inflammasome and immune disorders
- Cardiovascular and Diving-Related Complications
- Blood transfusion and management
- Obstructive Sleep Apnea Research
- Cancer, Stress, Anesthesia, and Immune Response
- Neuropeptides and Animal Physiology
Yonsei University
2016-2025
Yonsei University Health System
2009-2025
Severance Hospital
2014-2024
Pain Management Institute
2006-2024
Gangnam Severance Hospital
2016
Ajou University
2016
Pain and Rehabilitation Medicine
2015
Marymount University
2006-2010
National Institutes of Health
2007
Cleveland Clinic
2007
Introduction:Perioperative anesthesia and analgesia exacerbate immunosuppression in immunocompromised cancer patients.The natural killer (NK) cell is a critical part of anti-tumor immunity.We compared the effects two different methods on NK cytotoxicity (NKCC) patients undergoing breast surgery.Methods: Fifty resection were randomly assigned to receive propofol-remifentanil with postoperative ketorolac (Propofol-ketorolac groups) or sevoflurane-remifentanil fentanyl (Sevoflurane-fentanyl...
daVinci robot-assisted laparoscopic radical prostatectomy (RALP) requires pneumoperitoneum in the steep Trendelenburg position, which results increased intracranial pressure and cerebral blood flow. The aim of this study was to evaluate effect a 30 degrees position on oxygenation using regional oxygen saturation (rSO2).Thirty-two male patients ASA I II physical status without previous episodes ischemia or hemorrhage undergoing RALP were enrolled. rSO2 continuously monitored with...
Abstract Pericytes are believed to originate from either mesenchymal or neural crest cells. It has recently been reported that pericytes play important roles in the central nervous system (CNS) by regulating blood-brain barrier homeostasis and blood flow at capillary level. However, origin of CNS microvascular mechanism their recruitment remain unknown. Here, we show a new source cerebrovascular during neurogenesis. In embryonic day 10.5 mouse embryos, CD31 + F4/80 hematopoietic lineage...
Abstract Postoperative delirium is a common neuropsychiatric syndrome resulting high postsurgical mortality rate and decline in postdischarge function. Extensive research has been performed on both human animal delirium-like models due to their clinical significance, focusing systematic inflammation consequent neuroinflammation playing key role the pathogenesis of postoperative cognitive dysfunctions. Since are widely utilized for pathophysiological study disorders, this aimed at examining...
Any persistent degree of cognitive impairment in older adults is a concern as it can progress to dementia. This study aimed determine the incidence and risk factors for early postoperative dysfunction (POCD) elderly patients undergoing spine surgery.
Purpose: Emergence agitation (EA) is frequently observed in children undergoing general anaesthesia.This study tested whether the addition of an intra-operative low-dose infusion dexmedetomidine to fentanyl treatment reduced incidence emergence delirium following desflurane anesthesia strabismus surgery.Materials and Methods: A total 96 (1-5 years old) surgery were enrolled.Anaesthesia was induced with propofol maintained desflurane.After induction, (1 μg/kg) administered all children.During...
Inflammation is implicated in ischemic stroke and involved abnormal homeostasis. Activation of the immune system leads to breakdown blood-brain barrier and, thereby, infiltration cells into brain. Upon cerebral ischemia, infiltrated macrophages microglia (resident CNS cell) are activated, change their phenotype M1 or M2 based on microenvironment, migrate toward damaged tissue, repair damage. Those release pro-inflammatory mediators, which associated with tissue damage, while those...
The link between periodontitis and intestinal dysbiosis, two factors that contribute to atherosclerosis, has not been clearly defined. We investigated the integrative effects of oral infection with Porphyromonas gingivalis (PG), major pathogen for periodontitis, on microbiota atherosclerosis.ApoE-/- mice were fed a normal chow diet (NC), Western (WD) or WD PG (PG). was by placing total 109 CFUs live into cavity each mouse using feeding needle five times week 3 weeks. Atherosclerotic lesions...
Epidural cannulation is technically difficult in children who have small anatomic structures. Ultrasound information regarding the distance of skin-to-ligament flavum may be useful, leading to an increase success rate without dural puncture. This study was performed assess whether ultrasound-measured, would reflect needle depth during epidural puncture infants and children.The compromised 180 children, aged 2 84 months, undergoing urologic surgery. After induction anesthesia, ultrasound...
Background Although acetaminophen has been used widely and is well tolerated in children, its efficacy safety have not clarified when combined with an opioid intravenous parent-/nurse-controlled postoperative analgesia. Methods Sixty-three children (aged 6-24 months) who had undergone elective ureteroneocystostomies were enrolled this prospective, randomized, double-blinded study. After the surgery, analgesic pump was programmed to deliver fentanyl at a basal infusion rate of 0.25...
Postoperative cognitive dysfunction (POCD) may be driven by transference of the innate immune response to brain after aseptic surgical damage. Macrophages are key mediators immunity that can display a pro-inflammatory M1 phenotype or an anti-inflammatory M2 phenotype. Erythropoietin (EPO) is hematopoietic hormone exerts effects influencing macrophage function. We hypothesized EPO would prevent POCD promoting switching post-surgery. To evaluate on and polarization post-surgery, we...
Objective To investigate the effects of single‐dose intravenous dexamethasone on inflammatory responses, pain, nausea, and vomiting after uterine artery embolisation ( UAE ). Design Prospective, randomised, double‐blind, placebo‐controlled study. Setting Tertiary‐care University centre in Korea. Population Patients undergoing for treatment symptomatic fibroids or adenomyosis. Methods were randomised to receive either (10 mg; group) normal saline (control 1 hour before . Both groups received...
The role of nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome in the pathogenesis hepatic encephalopathy (HE) is unclear. Mitochondrial reactive oxygen species (mtROS) a signal for NLRP3 activation. Therefore, we aimed to determine whether mtROS-dependent activation involved HE, using vivo and vitro models.Bile duct ligation (BDL) C57/BL6 mice was used as an HE model. assessed hippocampus. Immunofluorescence staining performed cellular source hippocampal...
In Brief The Cavitron Ultrasonic Surgical Aspirator (CUSA®) is an innovative tool for resecting hepatic parenchyma, which reduces intraoperative blood loss and perioperative morbidity. We designed this study to compare the incidence severity of venous air embolism (VAE) detected via transesophageal echocardiography (TEE) during resection by using either clamp-crushing method or CUSA® method. Fifty patients scheduled were randomly assigned receive (CC group) (CUSA® group). After induction...
Although caudal block via the sacral hiatus is a common regional technique in children, it sometimes difficult to identify hiatus. A needle approach S2-3 interspace can be used as an alternative conventional approach. The authors compared feasibility and clinical characteristics between hiatal approach, addition ultrasound study.Sacral space depth, dural sac end level, depth were evaluated using with high-frequency linear probe lateral decubitus position 317 anesthetized children (study 1)....
Propofol is an anesthetic agent that gained wide use because of its fast induction anesthesia and rapid recovery post-anesthesia. However, previous studies have reported immediate neurodegeneration long-term impairment in spatial learning memory from repeated neonatal propofol administration animals. Yet, none those has explored the sex-specific physical changes behavioral alterations such as social (sociability preference), emotional (anxiety), other cognitive functions (spatial working,...