A5070994962- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Renal and related cancers
- User Authentication and Security Systems
- Advanced Authentication Protocols Security
- Peripheral Artery Disease Management
- Stroke Rehabilitation and Recovery
- Receptor Mechanisms and Signaling
- Intracranial Aneurysms: Treatment and Complications
- Venous Thromboembolism Diagnosis and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Cryptography and Data Security
- Neuropeptides and Animal Physiology
- Protein Degradation and Inhibitors
- Security in Wireless Sensor Networks
- Liver Disease Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Renal and Vascular Pathologies
- Cancer-related gene regulation
- Protein Kinase Regulation and GTPase Signaling
- Epigenetics and DNA Methylation
- Renal cell carcinoma treatment
- Head and Neck Cancer Studies
- Aortic Disease and Treatment Approaches
- Radiomics and Machine Learning in Medical Imaging
Children's Hospital of Chongqing Medical University
2022-2023
Chongqing Medical University
2022-2023
First Affiliated Hospital of GuangXi Medical University
2016-2023
Guangxi Medical University
2016-2023
Hunan Normal University
2014-2023
China International Science and Technology Cooperation
2022
National Clinical Research
2022
Hunan Provincial People's Hospital
2021
Weatherford College
2021
Harbin Institute of Technology
2017-2019
An Internet of Vehicles (IoV) allows forming a self-organized network and broadcasting messages for the vehicles on roads. However, as data are transmitted in an insecure network, it is essential to use authentication mechanism protect privacy vehicle users. Recently, Ying et al. proposed protocol IoV claimed that could resist various attacks. Unfortunately, we discovered their suffered from offline identity guessing attack, location spoofing replay consumed considerable amount time...
High revascularization rates in large-vessel occlusion strokes treated by mechanical thrombectomy are not always associated with good clinical outcomes. We evaluated predictors of functional dependence despite successful among patients acute ischemic stroke thrombectomy.We analyzed the pooled data from Multi Mechanical Embolus Removal Cerebral Ischemia (MERCI), Thrombectomy Revascularization Large Vessel Occlusions Acute Ischemic Stroke (TREVO), and TREVO 2 trials. Successful was defined as...
Background Collaterals may affect revascularization, ischemic severity, and clinical outcomes in acute stroke owing to internal carotid artery (ICA) occlusion. Objective To examine the hypothesis that morphology of occlusive thrombus collateral flow patterns influence outcome ICA occlusions after mechanical thrombectomy. Methods Pooled analyses MERCI Multi-MERCI trials employed central angiography review readings categorize lesions as I, L, or T clots functional based on patterns....
Background and Purpose— Several outcome prediction scores have been tested in patients receiving acute stroke treatment with previous generations of endovascular devices. The TREVO-2 trial was a randomized controlled comparing novel device (the Trevo device) to previous-generation Merci device). Methods— We used data from the validate Totaled Health Risks Vascular Events (THRIVE) score third-generation compare THRIVE other predictive scores. logistic regression model outcomes compared...
Both environmental cues and intracellular bioenergetic states profoundly affect pH (pHi). How a cell responds to pHi changes maintain homeostasis remains elusive. Here we show that Smad5, well-characterized downstream component of bone morphogenetic protein (BMP) signaling changes. Cold, basic or hypertonic conditions increase pHi, which in turn dissociates protons from the charged amino acid clusters within MH1 domain prompting its relocation nucleus cytoplasm. On other hand, heat, acidic...
The purpose of the current study is to investigate effect opioid-independent, heterologous activation protein kinase C (PKC) on responsiveness opioid receptor and underlying molecular mechanisms. Our result showed that removing terminus δ (DOR) containing six Ser/Thr residues abolished both DPDPE- phorbol 12-myristate 13-acetate (PMA)-induced DOR phosphorylation. phosphorylation levels mutants T352A, T353A, T358A/T361A/S363S were comparable wild-type DOR, whereas S344G substitution blocked...
Beta-arrestins are key negative regulators and scaffolds of G protein-coupled receptor (GPCR) signalling. Beta-arrestin1 beta-arrestin2 preferentially bind to the phosphorylated GPCRs in response agonist stimulation, resulting internalization desensitization. The critical roles GPCR kinases (GRKs)-catalyzed phosphorylation interaction beta-arrestins with well established. However, emerging evidence suggests that an agonist-stimulated mechanism is independent may also be employed some cases,...
Background The use of periprocedural heparin has previously been reported to be safe and potentially beneficial during thrombectomy with older generation devices. We aimed evaluate the safety clinical outcomes in stent retriever era. Methods A post hoc analysis TREVO 2 trial was performed comparing baseline characteristics between patients who received (HEP+) those did not receive (HEP−) while undergoing MERCI or clot retrieval. Results Of 173 patients, 58 (34%) including 40 one...
Session initiation protocol (SIP) is the most widely used application layer control for creating, modifying, and terminating session processes. Many authentication schemes have been proposed SIP aimed at providing secure communication. Recently, a new key agreement scheme has proposed, it was claimed that could resist variety of attacks. However, in this paper, we show vulnerable to an offline password guessing attack stolen memory device attack. Furthermore, lacks verification mechanism...
Wilms tumour (WT) is the most common kidney malignancy in children. Chemoresistance leading cause of recurrence and poses a substantial therapeutic challenge. Increasing evidence has underscored role immune microenvironment (TIM) cancers potential for immunotherapy to improve prognosis. There remain no reliable molecular markers reflecting landscape predicting patient survival WT. Here, we examine differences gene expression by high-throughput RNA sequencing, focused on differentially...
Renal fibrosis is a common pathological feature of various kidney diseases, leading to irreversible renal failure and end-stage disease. However, there are still no effective treatments reverse fibrosis. This study aimed explore the potential mechanism targeted drug for Here, unilateral ureteral obstruction (UUO)-treated mice TGF-β1-treated human tubular epithelial cell line (HK-2 cells) were used as models Based on changes mRNA in UUO kidneys detected by transcriptome sequencing, MK-2206,...
Neuroblastoma (NB) is the most frequent solid tumor in pediatrics, which accounts for roughly 15% of cancer-related mortality children. NB exhibited genetic, morphologic, and clinical heterogeneity, limited efficacy available therapeutic approaches. Recently, a new term 'cuproptosis' has been used to denote unique biological process triggered by action copper. In this instance, selectively inducing copper death likely successfully overcome limitations conventional anticancer drugs. However,...
Wilms tumour (WT) is a mixed type of embryonal that usually occurs in early childhood. However, our knowledge the pathogenesis or progression mechanism WT inadequate, and there scarcity beneficial therapeutic strategies. High-throughput RNA sequencing was employed this study to identify differentially expressed genes (DEGs) clinical tumor samples matching normal tissues. The STRING database utilized build protein-protein interaction (PPI) network, Cytohubba method used top 10 highly related...
Background There has been a growing interest in improving systems of care for the endovascular treatment acute ischemic stroke. We analyzed data from previous registries and studies to determine if there an improvement times reperfusion with increasing experience. Methods pooled Multi Mechanical Embolus Removal Cerebral Ischemia (MERCI), MERCI Registry Thrombectomy Revascularization Large Vessel Occlusions (TREVO), TREVO 2 trials assessed last known normal puncture, hospital arrival...
Objective To investigate the role of chemokines in Wilms tumours, especially their chemotaxis to immune cells and DNA methylation regulating expression level chemokines. Methods RNAseqV2 gene clinical data were downloaded from TARGET database. GEO cBioPortal The difference analysis Kaplan-Meier(KM) performed by edgeR package. Then predictive model based on was constructed lasso regression multivariate COX regression. ROC curve, DCA Calibration Nomogram used evaluate prognostic model....
Papillary thyroid carcinoma (PTC) is often combined with other types of disease, such as Hashimoto's thyroiditis (HT), nodular goiter (NG), follicular adenoma (FA) and types.However, the function these diseases in PTC tumorigenesis development not well understood.In this research, 563 patients were recruited divided into two groups according to pathological diagnosis, namely simple (PTC+).Clinicopathological characteristics BRAF V600E mutation status compared between PTC+.Our data showed...
Background Optimal patient selection is needed to maximize the therapeutic benefit of endovascular therapy for large vessel occlusion stroke. Aims To validate Pittsburgh response (PRE) score in a randomized controlled trial (Trevo2) comparing stent retriever (Trevo) Merci device. Methods Trevo2 participants with internal carotid, M1 and M2 middle cerebral artery occlusions prospectively collected baseline stroke severity (NIHSS), degree hypodensity (CT ASPECTS), three-month modified Rankin...
The impact of baseline ischemia on Alberta Stroke Program Early CT Score (ASPECTS) and evolution over 24 hours may be distinct in late thrombectomy. We analyzed predictors serial ASPECTS clinical outcomes the DAWN trial (Diffusion-Weighted Imaging or CTP Assessment With Clinical Mismatch Triage Wake-Up Late Presenting Strokes Undergoing Neurointervention Trevo).The Core Laboratory independently scored at hours. Descriptive statistics characterized computed tomography/magnetic resonance...
Abstract Background Previous studies have revealed obesity, nutrition, lifestyle, genetic and epigenetic factors may be risk for the occurrence development of non-alcoholic fatty liver disease (NAFLD). However, effect total polyunsaturated acid (PUFA) consumption on NAFLD is uncertain. Therefore, this study aimed to determine whether PUFA intake independently associated with explore threshold better illustrate correlation between them in Chinese Han adults. Methods The present was a...