A5101589668- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Pancreatic function and diabetes
- MicroRNA in disease regulation
- Peptidase Inhibition and Analysis
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Osteoarthritis Treatment and Mechanisms
- Orthopedic Infections and Treatments
- RNA Research and Splicing
- Paraoxonase enzyme and polymorphisms
- Endoplasmic Reticulum Stress and Disease
- Aldose Reductase and Taurine
- Atherosclerosis and Cardiovascular Diseases
- Protease and Inhibitor Mechanisms
- Osteomyelitis and Bone Disorders Research
- Bone fractures and treatments
- Ion Transport and Channel Regulation
- Immune cells in cancer
- Medical Imaging and Analysis
- Neuroendocrine Tumor Research Advances
- Spine and Intervertebral Disc Pathology
- Cancer-related gene regulation
- Extracellular vesicles in disease
- Congenital heart defects research
Guangxi Medical University
2022-2025
First Affiliated Hospital of GuangXi Medical University
2022-2025
Alibaba Group (China)
2025
Fifth Affiliated Hospital of Sun Yat-sen University
2009-2020
Sun Yat-sen University
2009-2020
Universidad de Huánuco
2008
The University of Adelaide
1993-1998
Objective This study sought to explore the clinical value of matrix metalloproteinases 12 ( MMP12) in multiple cancers, including lung adenocarcinoma (LUAD). Methods Using >10,000 samples, this retrospective demonstrated first pan-cancer analysis MMP12. The expression MMP12 between cancer groups and their control was analyzed using Wilcoxon rank-sum tests. significance cancers assessed receiver operating characteristic curves, Kaplan–Meier univariate Cox analysis. A further LUAD-related...
Abstract Long Non‐Coding RNA Reprogramming (lncRNA‐ROR) plays an important role in regulating various biologic processes, whereas the effect of lncRNA‐ROR osteoarthritis (OA) is little studied. This study aimed to explore expression articular cartilage and identify functional mechanism OA. OA tissues were obtained from 15 patients, 6 normal set as controls. Chondrocytes isolated collected tissues. was knockdown cells overexpressed cells. Cell viability determined with Counting Kit‐8 assay,...
Background Anaphase-promoting complex subunit 1 (ANAPC1) is a regulator of cellular mitosis and an important factor in tumorigenesis. To date, comprehensive assessment the potential role, biological behaviours, clinical significance ANAPC1 colorectal cancer (CRC) still lacking. Materials methods This study integrated 2329 mRNA expression data, single-cell RNA sequencing (scRNA-seq), internal immunohistochemistry 416 tissue samples to comprehensively evaluate abnormal pattern CRC. It also...
The choroid plexus (CP), an important structure involved in cerebrospinal fluid (CSF) circulation, plays a key role clearing harmful metabolites from the brain. However, relationship between CP and development of Parkinson's disease (PD) remains unclear, especially those with freezing gait (FOG). We aim to investigate association area CP/lateral ventricle (CP/Ven) index clinical symptoms PD FOG. Seventy-three patients (17 FOG 56 without FOG) 49 healthy controls (HCs) underwent 7 T magnetic...
Osteoarthritis (OA), characterized by degradation of articular cartilage, is a leading cause disability. As the only cell type present in chondrocytes play curial roles progression OA. In our study, we aimed to explore miR-23b lipopolysaccharide (LPS)-induced inflammatory injury.LPS-induced injury ATDC5 cells was evaluated loss viability, enhancement apoptosis, alteration apoptosis-associated proteins, and release cytokines. Then, level after LPS treatment assessed qRT-PCR. Next, effects...
Background. This study was aimed at elucidating the molecular biological mechanisms of microRNA-1 (miR-1) in nasopharyngeal carcinoma (NPC). Method. In this study, we performed a pooled analysis miR-1 expression data derived from public databases, such as GEO, ArrayExpress, TCGA, and GTEx. The miRWalk 2.0 database, combined with mRNA microarray datasets, used to screen target genes, genes were then subjected Kyoto Encyclopedia Genes Genomes (KEGG) Gene Ontology (GO) enrichment using DAVID...
Galactosyltransferase activity was measured in the luminal plasma of cauda epididymidis mice, rats, rabbits, rams and boars, rete testis fluid boars. The activities nucleotide pyrophosphatase alkaline phosphatase, which compete with galactosyltransferase for substrate, were also determined. In these species, similar when inhibitory effect phosphatase minimized by assay conditions. However, under conditions that did not minimize enzymes, species very different inversely correlated...
<title>Abstract</title> Background Limited evidence suggests that nucleolar protein interacting with the FHA domain of MKI67 (NIFK) plays a significant role in tumour occurrence and development. The mechanism clinical value NIFK colorectal cancer (CRC) still lack comprehensive evaluation. Materials Methods Cancerous tissue paracancerous 266 CRC patients were collected for immunohistochemistry, mRNA expression profiles 2262 1297 non-CRC worldwide analysed at levels. Analyse effect knocking...
Background: To investigate the role of miR-186 in carcinogenesis and metastasis human urothelial bladder cancer its potential target protein.
The same low M(r) protein fraction of epididymal luminal fluid as that studied previously by Hamilton in 1981 was assayed for alpha-lactalbumin (alpha-lac) activity with bovine milk galactosyltransferase (GalTase) the enzyme source and serum albumin (BSA) to make total concentrations all samples each assay constant. No alpha-lac could be detected this fraction. When glucose used an acceptor, radioactivity passing through ion exchange column retain remaining UDP-galactose did increase amount...
Objective To investigate the relationship among platelet membrane glucoproteins (GP Ⅱ b/Ⅲa and P-selectin) hs-CRP in patients with coronary artery disease.Methods Subjects were divided into 2 groups (40 disease,30cases of healthy subjects).Positive rates PAC-1 Pselectin measured tricolor flow cytometry.Hemorrheology was determined,and positive GP b/ Ⅲ a P-selectin cytometry.Hs-CRP levels by nephelometry turbidimetry normal controls.Results Compared group,hs-CRP expressions both a、P-selectin...
Background: The risk of venous thromboembolism in lung cancer is experiencing a prominent increase while the factors remains controversial.Materials and Methods: EBSCO MEDLINE (PubMed) databases were searched for studies on VTE cancer, which evaluated quality by conducting Newcastle Ottawa Scale. Risk corresponding odds ratios (ORs) calculated, with ORs combined through meta-analysis. A new prediction model patients was constructed, verified data 159 collected from our unit.Results:...
This article has been withdrawn at the request of publisher in December 2020.