A5042688965- Effects and risks of endocrine disrupting chemicals
- Pharmaceutical and Antibiotic Environmental Impacts
- Sperm and Testicular Function
- Carcinogens and Genotoxicity Assessment
- Toxic Organic Pollutants Impact
- Microplastics and Plastic Pollution
- Reproductive Biology and Fertility
- Reproductive Physiology in Livestock
- Genetically Modified Organisms Research
- Reproductive Health and Technologies
- Pesticide Exposure and Toxicity
- Child Nutrition and Water Access
- Environmental Science and Water Management
- Assisted Reproductive Technology and Twin Pregnancy
- Epigenetics and DNA Methylation
- Environmental Chemistry and Analysis
- Birth, Development, and Health
- Chemistry and Chemical Engineering
- Environmental Toxicology and Ecotoxicology
- Health, Environment, Cognitive Aging
- Water Treatment and Disinfection
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Chemical Analysis and Environmental Impact
- Thyroid Disorders and Treatments
- Wastewater Treatment and Reuse
Steve Biko Hospital
1998-2025
University of Pretoria
2016-2025
Faculty of Public Health
2007
Instituto Nacional de Salud Pública
2007
Tshwane University of Technology
2007
University of Limpopo
2007
The pesticide DDT [1,1,1-trichloro-2,2-bis(chlorodiphenyl)ethane] is 1 of the 12 persistent organic pollutants (POPs) under negotiation at Stockholm Convention to restrict or ban their production and use because toxicity, resistance breakdown, bioaccumulation, potential for being transported over long distances. has estrogenic potential, main metabolite, p,p'-dichlorodiphenyl-dichloroethylene (p,p'-DDE), a potent antiandrogen. In response mounting evidence on endocrine-disrupting influence...
Biomedical science is rapidly developing in terms of more transparency, openness and reproducibility scientific publications. This even important for all studies that are based on results from basic semen examination. Recently two concordant documents have been published: the 6th edition WHO Laboratory Manual Examination Processing Human Semen, International Standard ISO 23162:2021. With these tools, we propose authors should be instructed to follow laboratory methods order publish...
The organochlorine dichlorodiphenyltrichloroethane (DDT) is banned worldwide owing to its negative health effects. It exceptionally used as an insecticide for malaria control. Exposure occurs in regions where DDT applied, well the Arctic, endocrine disrupting metabolite, p,p′-dichlorodiphenyldichloroethylene (p,p′-DDE) accumulates marine mammals and fish. p,p′-DDE exposures are linked birth defects, infertility, cancer, neurodevelopmental delays. Of particular concern potential of use impact...
Background: Africa faces a number of unique environmental challenges. Unfortunately, it lacks the infrastructure needed to support comprehensive studies that could provide scientific basis inform policies. There are known sources endocrine-disrupting chemicals (EDCs) and other hazardous in Africa. However, coordinated approach identify monitor these contaminants develop strategies for public health interventions has not yet been made. Objectives: This commentary summarizes evidence presented...
There is mounting evidence that deteriorated semen quality may be associated with increased serum concentration of 1,1,1-trichloro-2,2-bis(chlorodiphenyl)ethane (DDT) and its metabolites. The problem exacerbated in situations where DDT the only resource available to control malaria mosquitoes metabolite plasma can reach 1000-fold level found other populations. are limited contradictory epidemiological data on whether DDT/dichlorodiphenyl-dichloroethylene (DDE) also damage sperm DNA....
In South Africa, limited data are available regarding possible oestrogenic activity in the aquatic systems and especially drinking water. Water rural areas is often contaminated with a complex mixture of toxic compounds originating from nearby industries, agriculture households. these only access to water boreholes, natural springs rivers. Thus human exposure environmental contaminants potentially high. Two communities near Mokopane Waterberg district Limpopo Province were selected order...
Abstract Purpose Contemporary antiretroviral (ARV) medications are used by millions of men for HIV treatment worldwide. Limited data exist on their direct effect sperm motility. This pilot study hypothesizes that in vitro exposure to ARVs will reduce kinematic and motility parameter values. Methods laboratory-based experimental analyzed kinematics after the Dolutegravir, Tenofovir, Emtricitabine, individually combination. Each participant (n = 23) served as control. The Microptic SCA®...
Increasing concern about endocrine disrupting chemicals (EDCs) and their effects on humans, animals the environment resulted in this study being conducted. Water from 7 sites Pretoria West area (South Africa), with significant numbers of small-sized industries, was screened for oestrogenicity, using Recombinant Yeast Cell Bioassay (RCBA). Target chemical analyses were carried out to establish presence EDCs, including p-nonylphenol (p-NP), bisphenol A (BPA), phthalate esters, polychlorinated...
Abstract Potential endocrine disrupting chemicals (EDCs) are present in bottled water from various countries. In South Africa (SA), increased consumption and concomitant increases plastic packaging create important consequences for public health. This study aimed to screen SA estrogenic activity, selected target assessing potential health risks. Ten brands were exposed 20 °C 40 over 10 days. Estrogenic activity was assessed using the recombinant yeast estrogen (YES) T47D-KBluc reporter gene...
The insecticide dichlorodiphenyltrichloroethane (DDT) has been used for malaria vector control in the northern and eastern parts of Vhembe District Limpopo Province, South Africa, since 1945. Bioaccumulation DDT raises concern because it reportedly affects thyroid function.Our objective was to investigate association between uptake (as reflected plasma concentrations) homeostasis while considering related factors.We compared dietary intake, serum retinol-binding protein (RBP), transthyretin...
Abstract A preliminary assessment was made of oestrogenic activity in water sources the Rietvlei Nature Reserve, from which is supplied to metropolitan area Pretoria. Single samples were extracted seven sites using a solid phase C18 cartridge and extracts assessed for Recombinant Yeast Screen bio-assay. Estradiol equivalents ranged 0.31–2.1 ng l−1, are comparable those reported rivers near Paris (1.0–32 l−1) environmental Korea (0.5 pg l−1 7.4 l−1). The found supported by report intersex...
Many chemicals released into the environment are believed to disrupt normal endocrine functions in humans and animals. These disrupting (EDCs) affect reproductive health development. A major group of EDCs that could be responsible for effects those mimic natural oestrogens, known as xeno-oestrogens. number vivo vitro screening strategies being developed identify classify xeno-oestrogens, order determine whether they pose a risk It is also important able apply assays environmental samples...
Health agencies recommend using hand sanitisers as protection against the coronavirus. Thus far, emphasis on sanitiser studies is limited to an analysis of disinfectant content only. This study aims provide extended 60 off-the-shelf alcohol-based by gas chromatography report alcohol and presence impurities, a recombinant yeast estrogen screen assess estrogenic activity, investigation into labelling compliance with South African National Standard. Fifty had ≥60% v/v alcohol; however, most...
On the occasion of XIIIth International Symposium on Spermatology held from 9 to 13 May 2018 in Stockholm (Sweden), participants (guest speakers and audience) collectively felt need make a public statement general issue male reproductive health. Our intention is raise awareness what we believe neglected area research despite alarming situations around world. The disclosure strategy desired by co-authors bring it attention greatest number partly considering co-publication various periodicals...