A5090958517- Acute Ischemic Stroke Management
- Pluripotent Stem Cells Research
- Liver physiology and pathology
- CRISPR and Genetic Engineering
- Stroke Rehabilitation and Recovery
- Metal and Thin Film Mechanics
- Plant Molecular Biology Research
- Diverse Topics in Contemporary Research
- Diverse Approaches in Healthcare and Education Studies
- Pharmacogenetics and Drug Metabolism
- Titanium Alloys Microstructure and Properties
- Chronic Disease Management Strategies
- Hydrogen embrittlement and corrosion behaviors in metals
- Korean Urban and Social Studies
- Technology and Data Analysis
- Venous Thromboembolism Diagnosis and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Photosynthetic Processes and Mechanisms
- Nasal Surgery and Airway Studies
- Sinusitis and nasal conditions
- Image and Video Quality Assessment
- Phytochemistry and Biological Activities
- Alcoholism and Thiamine Deficiency
- Artificial Intelligence in Healthcare
- GABA and Rice Research
Beth Israel Deaconess Medical Center
2025
Harvard University
2025
Wonkwang University
2024-2025
University of Colorado Colorado Springs
2025
Pohang University of Science and Technology
2024-2025
Health Insurance Review and Assessment Service
2018-2024
Macquarie University
2024
Seoul National University
2008-2024
Chungnam National University
2022-2024
Pusan National University
2024
<h3>Importance</h3> Current guidelines recommend ticagrelor as the preferred P2Y12 platelet inhibitor for patients with acute coronary syndrome (ACS), primarily based on a single large randomized clinical trial. The benefits and risks associated vs clopidogrel in routine practice merits attention. <h3>Objective</h3> To determine association of ischemic hemorrhagic events undergoing percutaneous intervention (PCI) ACS practice. <h3>Design, Setting, Participants</h3> A retrospective cohort...
Human in vitro hepatic models that faithfully recapitulate liver function are essential for successful basic and translational research. A limitation of current models, which extensively used drug discovery toxicity testing, is the loss metabolic due to low expression activity cytochrome P450 (CYP450) enzymes. Here, we aimed generate human pluripotent stem cell-derived organoids (hHOs) with a high ability. We established two-step protocol produce hHOs from cells long-term expansion testing....
We investigated the surgical anatomy of sphenopalatine artery. First, location foramen on lateral nasal wall and pattern main branches artery from were studied. Second, course posterior with respect to maxillary sinus, perpendicular plate palatine bone, distribution its fontanelle was determined. Third, inferior turbinate analyzed.Fifty midsagittal sections randomly selected Korean adult cadaver heads intact sphenoid sinus surrounding structures used in study.The mucosa removed a...
Transparent and FAIR disclosure of meta-information about healthcare data infrastructure is essential but has not been well publicized. In this paper, we provide a transparent the process standardizing common model developing national using claims data. We established an Observational Medical Outcome Partnership (OMOP) database for Health Insurance Review Assessment Service South Korea. To introduce openness policy, built distributed analysis environment released metadata based on principle....
This study analyzed how the rural tourism system in Jinan County, South Korea, has declined and suggested ways to revitalize resources. The causal loop diagram, which is a research method that can structure analyze of tourism, was utilized understand Jinan, focusing on subject, objects, media tourism. found following results. First, decline due conflict values surrounding Mt. Maisan as resource delay road railway accessibility. In addition, regard infrastructure services presence livestock...
Background: Student-run free clinics (SRFCs) play a crucial role in providing preventive healthcare and addressing disparities, especially underserved communities. However, dermatologic care remains largely unavailable SRFCs. This review examines the need for dermatology-centered SRFCs, evaluates current literature, suggests ways to enhance access populations, focusing on Camden County, New Jersey. Methods: A comprehensive literature was conducted using PubMed, Embase, Cochrane, Google...
Background: Optimal antithrombotic regimens to prevent recurrent stroke in patients with ischemic due atrial fibrillation (AF) and atherosclerotic large-vessel stenosis remain unknown. Aims: This study aimed evaluate the effect of multiple therapies on outcomes at 1 year after two or more causes. Methods: We identified 862 AF large artery atherosclerosis from linked data. These were categorized into three groups according discharge: (1) antiplatelets, (2) oral anticoagulants (OAC), (3)...
Post-stroke equinovarus foot (EVF) impairs gait stability, increases the risk of secondary injuries, and contributes to elevated healthcare costs. However, effective targeted interventions for EVF remain limited. Two patients with chronic EVF-a 63.5-year-old male (9.7 months post-stroke) a 35.7-year-old female (24.5 post-stroke)-presented ankle deformity, asymmetry, impaired balance, all which interfered daily activities. Both underwent ultrasound-guided acupotomy targeting spastic muscles,...
Although hepatocyte-like cells derived from human pluripotent stem (hPSC-HLCs) are considered a promising model for predicting hepatotoxicity, their application has been restricted because of the low activity drug metabolizing enzymes (DMEs). Here we found that expression xenobiotic receptors (constitutive androstane receptor, CAR; and pregnane X PXR) contributes to DMEs in hPSC-HLCs. Most CAR- PXR-regulated transporters were transcriptionally down-regulated hPSC-HLC. Transcriptional CAR PXR...
This article aims to introduce the inception and operation of COVID-19 International Collaborative Research Project, world's first coronavirus disease 2019 (COVID-19) open data project for research, along with its dataset research method, discuss relevant considerations collaborative using nationwide real-world (RWD). has spread across world since early 2020, becoming a serious global health threat life, safety, social economic activities. However, insufficient RWD from patients was...
In this study, the antioxidant activities of hot water extracts Rugosa rose (Rosa rugosa Thunb.) were evaluated. Total phenolic compounds (TPC) and total flavonoid (TFC) highest in leaf at 107.29 mg/g 24.28 mg/g, respectively. The DPPH (2,2-diphenyl-1-picrylhydrazyl) ABTS (2,2’-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt) radical scavenging activity was following order: flower extract > seed fruit extract. IC50 values for 0.87 mg/mℓ 0.27 mg/mℓ, amount gallic acid...
Background: Linkage of public healthcare data is useful in stroke research because patients may visit different sectors the health system before, during, and after stroke.Therefore, we aimed to establish high-quality big on Korea by linking acute registry national claim databases.Methods: Acute (n = 65,311) with suitable for linkage were included Clinical Research Center Stroke (CRCS) during 2006-2014.We linked CRCS databases Health Insurance Review Assessment Service (HIRA).Linkage was...
Background/Objectives: Artificial intelligence (AI)-assisted endoscopic ultrasonography (EUS) diagnostic tools have shown excellent performance in diagnosing gastric mesenchymal tumors. This study aimed to assess whether incorporating clinical and factors into AI-assisted EUS classification models based on digital image analysis could improve the of tools. Methods: We retrospectively analyzed data 464 patients who underwent both surgical resection tumors, including 294 gastrointestinal...
Background: Neurocritical care by dedicated neurointensivists may improve outcomes of critically ill patients with severe brain injury.In this study, we aimed to validate whether neurointensive could the outcome in acute ischemic stroke using linked big dataset on Korea.Methods: We included 1,405 mechanical ventilator support intensive unit after an index stroke.Patients were retrieved from linking Clinical Research Center for Stroke Registry and Health Insurance Review Assessment Service...
Human-induced pluripotent stem cells (hiPSCs) are invaluable sources for drug screening and toxicity tests because of their differentiation potential proliferative capacity. Recently, the CRISPR-Cas9-mediated homologous recombination system has enabled reporter knock-ins at desired loci in hiPSCs, here, we generated a hiPSC line expressing mCherry-tagged cytochrome P450 1A1 (CYP1A1), which can be utilized to screen modulators aryl hydrocarbon receptor (AHR) live cells. CYP1A1-mCherry hiPSCs...