A5081058046- Dialysis and Renal Disease Management
- Blood Pressure and Hypertension Studies
- Maternal Mental Health During Pregnancy and Postpartum
- Renal and Vascular Pathologies
- Child and Adolescent Psychosocial and Emotional Development
- Adolescent and Pediatric Healthcare
- Iron Metabolism and Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Bipolar Disorder and Treatment
- Functional Brain Connectivity Studies
- Child Abuse and Trauma
- Sodium Intake and Health
- Cardiovascular Health and Risk Factors
- Obstructive Sleep Apnea Research
- Sleep and related disorders
- Hemoglobinopathies and Related Disorders
- Gastroesophageal reflux and treatments
- MRI in cancer diagnosis
- Family Support in Illness
- Traumatic Brain Injury and Neurovascular Disturbances
- Renal Transplantation Outcomes and Treatments
- COVID-19 Impact on Reproduction
- Maternal and Perinatal Health Interventions
- Diet and metabolism studies
- Pharmacological Receptor Mechanisms and Effects
Children's Hospital of Philadelphia
2015-2023
Lifespan
2018-2023
University of Pennsylvania
2018-2023
Philadelphia University
2020-2021
University of Pennsylvania Health System
2020
Taipei Medical University
2018
Purpose To investigate the pathophysiologic effects of chronic kidney disease (CKD) on brain function in children with CKD by correlating cerebral blood flow (CBF) clinical and behavioral indexes. Materials Methods In this prospective study, 73 pediatric patients (mean age, 15.80 years ± 3.63; range, 9–25 years) 57 control subjects 15.65 3.76; were recruited. CBF measurements acquired an MRI arterial spin labeling scheme. Neurocognitive performed traditional computerized neurocognitive...
Neurocognitive problems in CKD are well documented; time-efficient methods needed to assess neurocognition this population. We performed the first study of efficient 1-hour Penn Computerized Battery (CNB) children and young adults with CKD.We administered CNB cross-sectionally individuals aged 8-25 years stage 2-5 (n=92, enrolled from three academic nephrology practices 2011 2014) matched healthy controls (n=69). analyzed results 12 tests four domains: executive control, episodic memory,...
Brain development during adolescence and early adulthood coincides with shifts in emotion regulation sleep. Despite this, few existing datasets simultaneously characterize affective dynamics, sleep variation, multimodal measures of brain development. Here, we describe the study protocol initial release (n = 10) an open data resource neuroimaging paired densely sampled behavioral nd adolescents young adults. All participants complete multi-echo functional MRI, compressed-sensing diffusion...
Abstract Decades of research have highlighted the importance optimal stimulation cortical dopaminergic receptors, particularly D1R receptor (D1R), for prefrontal-mediated cognition. This mechanism is relevant to cognitive deficits in schizophrenia, given abnormalities dopamine (DA) neurotransmission and expression D1R. Despite critical need D1R-based therapeutics, many factors complicated their development prevented this important therapeutic target from being adequately interrogated....
To compare behavior ratings of executive functioning in individuals with chronic kidney disease (CKD), using the Behavior Rating Inventory for Executive Functions (BRIEF), a typically developing comparison group and to examine correlation between severity functioning.Participants included 92 CKD (eGFR < 90 mL/min per 1.73 m), aged 8 25 years, recruited from nephrology clinics both hospital community settings. The ranged Stage II V. BRIEF was completed by parents younger than 18 years age...
Abstract Non‐dipping and nocturnal hypertension are commonly found during ABPM in pediatric kidney transplant recipients. These entities independently associated with increased cardiovascular disease risk adults. Kidney recipients aged 5‐21 years eGFR > 30 mL/min/1.73 m 2 demonstrating non‐dipping status normal daytime BP were randomized to intervention (short acting medication added the evening) or control (no change) this pilot, randomized, open‐label, blinded end‐point clinical trial....
Chronic kidney disease is strongly linked to neurocognitive deficits in adults and children, but the pathophysiologic processes leading these remain poorly understood. The NiCK study (Neurocognitive Assessment Magnetic Resonance Imaging Analysis of Children Young Adults with Kidney Disease) seeks address critical gaps our understanding biological basis for neurologic abnormalities chronic disease. In this report, we describe objectives, design, methods study.The Study a cross-sectional...
Pediatric systemic hypertension (HTN) is underdiagnosed and undertreated. The Divisions of Cardiology Nephrology at our institution developed a comprehensive outpatient HTN program to (1) screen children risk for HTN, (2) assess cardiovascular health, (3) optimize medical management. We report findings during all initial visits (n = 304) from December 2011 September 2018. Of the cohort, 38% were obese 36% reported little no exercise. More than half patients ≥11 years old did not have...
Objective. Brief, reliable, and cost-effective methods to assess parenting are critical for advancing research. Design. We adapted the Three Bags task Parent Child Interaction Rating System (PCIRS) rating online visits with 219 parent–child dyads (White, n = 104 [47.5%], Black, 115 [52.5%]) combined video data survey collected during pregnancy when children were aged 1. Results. The PCIRS codes of positive regard, stimulation child cognitive development, sensitivity showed high reliability...
Abstract Background SRBDs have been shown to increase the risk of cardiovascular disease, which is a significant cause mortality in kidney transplant recipients. Few studies investigated association between and cardiometabolic factors pediatric Methods This was cross‐sectional study recipients using baseline data from previous clinical trial (NCT01007994). Parents/guardians filled out 22‐item PSQ. A score greater than 33% defined as diagnosis SRBD. Fisher's exact test, Mann–Whitney U...
The COVID-19 pandemic has been linked to increased risk for perinatal anxiety and depression among parents, as well negative consequences child development. Less is known about how worries arising from the during pregnancy are related later development, nor if resilience factors buffer consequences. current study addresses this question in a prospective longitudinal design. Data was collected sub-study ( n = 184) of pregnant individuals (total 1,173). During (April 17-July 8, 2020) early...